Ukwelashwa komdlavuza webele kuthuthuke ngokushesha kakhulu eminyakeni embalwa edlule futhi kube nentuthuko entsha ekwelapheni umdlavuza webele. Umqondisi wocwaningo uDkt Juha Klefstorm at IYunivesithi yaseHelsinki osebenza isikhathi eside emsebenzini wocwaningo oluhlobene nomdlavuza uthole ukuthi amangqamuzana omdlavuza angahlaselwa “nge-drug cocktail” ehlanganisa umuthi wesifo sikashukela i-metformin kanye ne-venetoclax, i-BCL-2 protein inhibitor engadala i-apoptosis kumaseli omdlavuza. . Ithimba libonile i-metformin kuskena ngemithi engasiza umsebenzi we-apoptosis-actuating we-venetoclax. IVenetoclax ivunyelwe ukwelapha ama-leukemias athile kepha hhayi okwamanje ekwelashweni komdlavuza webele.
“Le nhlanganisela yomuthi ihlukumeza ubungozi obucacile be-metabolic okwenziwa inani elikhulu le-MYC isisu amaseli. I-Metformin ne-venetoclax, lapho inikezwa ndawonye, yahlaba amaseli wesimila samabele ngokwesiko futhi yavimba ukukhula kwesimila kumamodeli ezidalwa ezimbi ezikhula esifubeni. Ngaphezu kwalokho, imishanguzo isebenzise ngempumelelo izicubu ezikhula kahle zamabele ezinikezwa iziguli zesifo sebele. Ukuhlolwa kokonakala kwebele kwatholakala ngokuqondile ezinqubweni zezokwelapha ezenziwa esibhedlela sase-Helsinki University,” kusho uDkt. Klefstrom.
Kunoma ikuphi, ochwepheshe ngaphambi kwesikhathi eside bathola ukuthi i-metformin ngaphezu kokwelashwa kwe-venetoclax imane igcine izimila ngaphakathi kwemingcele efanele inqobo nje uma amagundane anamathumba esifuba ashunyekiwe ephathwa ngokuphumelelayo ngemithi; lapho ukwelashwa kuyekwa, amathumba abuyela emuva. Ukuhlola kubonisa ukuthi izimila ekuqaleni zazigcwele ama-lymphocyte abulala isimila; noma kunjalo, ngemva kokwelashwa anyamalala kakhulu futhi amanye amangqamuzana abulalayo axhumana ne-PD-1, umaka wokuncipha kwamangqamuzana angazweli.
Ukuze amangqamuzana angathinteki akwazi ukulwa nalesi simila, ochwepheshe bakhe olunye uhlelo lokwelapha. Okokuqala, bashaya izimila zamabele ngezidakamizwa ezisebenza nge-apoptosis i-metformin ne-venetoclax ukunciphisa ukuhlolwa kwesimila nokuvusa ama-lymphocyte abulalayo. Ngemuva kokuthi amathumba abalulekile ekhishwe ngokucophelela, amagundane abe esephathwa ngengxube ephindwe kathathu: i-metformin, i-venetoclax kanye ne-PD-1 egxile kumenzeli obambekayo, osetshenziswa kuma-immunotherapies ukugcina amaseli abulalayo edonsa isikhathi eside.
Ukwelashwa komdlavuza webele - uDkt Heidi Haikala
Umsunguli oyinhloko wezivivinyo uDkt Heidi Haikala uyakuqaphela lokhu: “Kuyamangalisa kakhulu ukuthi sinamandla kangakanani okuletha isambulo esihlalweni selabhu ibanga lonke kuze kube sekungeneni kwezikhungo zokukhula ezimbi ngaphakathi kwesikhathi se-PhD eyodwa venture. Sikhathazeke kakhulu ngokuthola kwethu nokulindela ukuthi kuzosiza iziguli ezikhulayo ezibulalayo. ”
“Leli yindaba engakholeki yokuthi abacwaningi emhlabeni wezifundiswa, besebenzisa izinhlobo zezimila ezigxile kakhulu futhi besebenzisa ulwazi lwabo olumangazayo, bangeza kanjani ekudalweni kwemithi emisha engaba khona yabantu abakhule kabi. Kanjalo futhi kungukubonakaliswa kocwaningo olungajwayelekile olwenziwa emazweni amancane kakhulu afana neFinland, ”kusho uJoel Leverson, Ph.D., onguMqondisi Omkhulu Wezesayensi e-AbbVie futhi ongomunye wabadali abaphezulu ophenyweni.
Ngethemba ukuthi eminyakeni ezayo kuzoba nentuthuko eyengeziwe ekwelashweni kwe umdlavuza webele.
