Umdlavuza we-pancreatic njengamanje ungomunye wemidlavuza ebulalayo kakhulu futhi emelana ne-chemotherapy. Muva nje, abacwaningi bomdlavuza e-Australia benze indlela ethembisa kakhulu ye-nanomedical ezothuthukisa ukwelashwa komdlavuza we-pancreatic.
This technology wraps drugs that can silence specific genes in nanoparticles and transport them to pancreatic tumors . It is expected to provide pancreatic cancer patients with alternatives to traditional treatments such as chemotherapy.
Experiments conducted on mice showed that the new nanomedicine method reduced isisu growth by 50% and also slowed the spread of pancreatic cancer.
Ucwaningo olushicilelwe kumaBiomacromolecule lwenziwa ososayensi abavela e-University of New South Wales (UNSW). Kuletha ithemba elisha ezigulini eziningi ezinomdlavuza we-pancreatic ezingaphila kuphela izinyanga ezingama-3-6 ngemuva kokuxilongwa.
UDkt. Phoebe Phillips we-UNSW Roy Cancer Research Centre (Lowy Cancer Research Centre) nguyena obephethe lolu cwaningo. Uthe noma nini lapho ozakwabo bodokotela kufanele bazise iziguli ezinomdlavuza we-pancreatic, Noma ngabe imishanguzo engcono kakhulu ye-chemotherapy ingabasiza kuphela ukwandisa izimpilo zabo amasonto ayi-16, odokotela empeleni ababekezeleleki kakhulu.
UDkt. Phillips wathi: “Isizathu esiyinhloko esenza ukwelapha ngamakhemikhali kungasebenzi ukuthi izimila zama-pancreas zinezinhlobonhlobo zezibazi, ezingaba amaphesenti angu-90 aso sonke isimila. Izicubu eziyisibazi zisebenza njengesithiyo esingokomzimba esivimbela izidakamizwa ukuthi zingafinyeleli esimila, okubangela umdlavuza wamanyikwe. Amaseli amelana nokwelashwa ngamakhemikhali. “
She explained: “Recently, we have discovered a key gene that promotes the growth, spread and resistance of pancreatic cancer-βIII-tubulin. Inhibiting this gene in mice not only reduced tumor growth by half, It also slows down the spread of cancer cells. “
Kodwa-ke, ukuze ucindezele lesi sakhi sofuzo ngokomtholampilo, umuntu kufanele anqobe ubunzima bokulawulwa kwezidakamizwa: ukweqa izicubu ezibomvu zamathumba e-pancreatic . Ukuxazulula le nkinga, abacwaningi base-Australia baye bahlakulela izindlela ze-nano-medical, ama-molecule amancane e-RNA (angaqondwa njengekhophi ye-DNA yeselula) ehlanganiswe nezinhlayiya ezithuthukisiwe ze-nano, lawa ma-molecule e-RNA afinyelela isimila ngemva kokukwazi ngokwezinga elikhulu, vimbela isakhi sofuzo se-βIII-tubulin.
Laba bacwaningi baye babonisa ukuthi kungenzeka yini ama-nanoparticles amasha kumagundane. Ama-nanoparticles awo angaletha imithamo yokwelapha ye-microRNA kumathumba e-pancreatic kumagundane lapho kukhona izicubu ezibomvu, futhi avimbele ngempumelelo i-βIII-tubulin.
“Okubalulekile kobuchwepheshe bethu be-nanomedicine ukuthi kulindeleke ukuthi kucindezelwe noma yiluphi uhlobo lofuzo olukhuthaza isimila, noma iqoqo lezakhi zofuzo 'ezenziwe ngokwezifiso' ngokusekelwe ekuvezweni kofuzo lwesimila sesiguli." Kusho uDkt Phillips.
"Lokhu kuzosiza abantu ukuthi basungule ukwelashwa okusha kwalomdlavuza ongazweli emithini futhi kuthuthukise ukusebenza kwezindlela ezikhona zamakhemikhali, ngaleyo ndlela kuthuthukiswe izinga lokusinda kanye nekhwalithi yempilo yeziguli ezinomdlavuza wepancreatic."
