The latest research found that some statins can improve the efficacy of chemotherapy drugs used to treat blood cancer in mouse models. Statins are drugs that treat patients with reduced fat in the blood. They are commonly used to lower triglyceride and cholesterol levels and reduce fat associated with heart attacks and strokes. In this new experiment, the researchers found that they may also be used to treat certain blood cancers.
Ucwaningo lwangaphambilini lubonise ukuthi ama-statins akhuthaza i-apoptosis (ukufa kwamangqamuzana emvelo) ezinhlotsheni ezithile zomdlavuza, futhi lokhu okutholakele kusikisela ukuthi angase abe usizo ekwelapheni la mdlavuza. Kulolu cwaningo, abacwaningi bathola ukuthi i-simvastatin ithuthukise ukusebenza kwe-Venetoclax ngokumelene ne-lymphocytic leukemia engapheli kumodeli yegundane. Kuyasiza ukunciphisa i-lymphoma ngokwandisa isignali ye-apoptosis kumaseli omdlavuza, okuholela ekukhuleni kwesikhathi sokusinda. Baphinde baveza ukuthi lokhu okutholakele kusebenza kakhulu kunanoma yimuphi umuthi onikezwe wodwa.
The researchers were encouraged by the results of this study and began three clinical trials involving the testing of Venetoclax for the treatment of chronic lymphocytic leukemia, looking for data on patients who had received statins. They found that these patients responded better to cancer by 2.7 times than those who did not take statins.
Abaphenyi bathi uma ama-statin enomphumela ofanayo kubantu, izigidi zabantu emhlabeni jikelele zivame ukuzisebenzisa ukwehlisa amazinga e-cholesterol. Ngaphezu kokwehlisa amafutha egazini, kukhonjisiwe nokuthi abanayo imiphumela emibi. Abaphenyi bakholelwa ukuthi ukuhlolwa komtholampilo kufanele kwenziwe ukuze kunqunywe ukuthi ngabe ama-statins angakusiza yini ukubikezela kweziguli ezine-leukemia namanye amagciwane egazi.
