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I-bosutinib yomugqa wokuqala iphakeme kune-imatinib ekwelapheni i-leukemia

Yabelana ngalokhu okuthunyelwe

I-Bosutinib iyi-Src / Abl dual tyrosine kinase inhibitor egunyazwe ukwelashwa kwesigaba esisanda kutholwa esingelapheki (CP) esingamahlalakhona i-myelogenous leukemia (CML), noma imelana noma ingabekezeleli ekwelashweni kwangaphambilini kwe-CML. Ucwaningo luqhathanise idatha yokwelashwa kwe-besutinib yomugqa wokuqala kanye ne-imatinib ezinyangeni ezingu-≥24 zokulandelela. I-BFORE iyisifundo somtholampilo esiqhubekayo, esinelebula elivulekile lesigaba III esinengqikithi yeziguli ezingama-536 ezibhalisiwe futhi zabelwe ngokungahleliwe ukuthola i-bursatinib (n = 268) noma i-imatinib (n = 268) ku-1: 1 yokwelashwa kwesilinganiso.

At a follow-up of 12 months, compared with the imatinib group, the bosutinib group showed higher molecular  remission (MR) and complete cytogenetic remission (CCyR). Futhi lo mehluko uqhubeke nokulandela ngemuva kwezinyanga ezingama-24. Ezinyangeni ezingama-24 zokulandelwa, amaqembu womabili akhombise umehluko omkhulu wokuxolelwa kwamangqamuzana (MMR), kepha umehluko phakathi kwe-MR4 ne-MR4.5 wawungabalulekanga. Uma kuqhathaniswa neqembu le-imatinib, isikhathi sokufinyelela ku-MR ne-CCyR sasifushane eqenjini le-bosutinib. Iziguli eziyisithupha eqenjini le-bosutinib neziguli eziyisikhombisa eziseqenjini le-imatinib ziguqulwe zaya esigabeni esisheshayo / esisheshayo. Ezinyangeni ezingama-24 zokulandelwa, uma kuqhathaniswa neqembu le-imatinib, iqembu le-bosutinib likhombise ukuxolelwa okukhulu kwamangqamuzana (MMR). Izifundo zisekela ukusetshenziswa kwe-bosutinib ekwelashweni komugqa wokuqala kweziguli ze-CP CML.

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