Lapho ngisebenza ekuthuthukiseni isimiso somzimba sokuzivikela ezifweni, ngathola ngephutha uhlobo olusha lwamangqamuzana olubulala umdlavuza omningi. Ukuphumelela okusha kungaba usizo olukhulu ezigulini ezinomdlavuza, njengoba i-t-cell esanda kutholwa ibulala izinhlobo eziningi zamangqamuzana omdlavuza. Kodwa-ke, lokhu kukhawulelwe kumalabhorethri kuze kube manje, futhi ucwaningo lwesikhathi eside luyadingeka ukuze kwakhiwe umuthi ophelele.
Ososayensi baseBrithani baseCardiff Medical University bathole ngephutha uhlobo lweseli (i-t-cell) elibhubhisa izinhlobo eziningi zomdlavuza. Njengokwe-Telegraph lokhu kungaba impumelelo enkulu ekuzingeleni ikhambi lomdlavuza lazo zonke izinhlobo zomdlavuza. Udokotela, ngenkathi ehlaziya amangqamuzana egazi amhlophe ebhange legazi, wathola uhlobo olusha lwe-t-cell ephethe isamukeli esisha esake sabonwa esisebenza njengehhuku elibambayo, esibambelela kumdlavuza wabantu abaningi, kuyilapho singanaki amaseli anempilo, I-Telegraph iyabika. Ezimweni zaselabhorethri, amangqamuzana omzimba afakwe isamukeli esisha, akwazile ukubulala amangqamuzana omdlavuza avela ezithweni eziningi, okuhlanganisa amaphaphu, igazi, amathambo nezinso.
Ngokusho kukaSolwazi Andrew Sewell, inhloko yocwaningo, nongoti wohlobo lwamaseli kwa I-Cardiff Medical University, lokhu okutholakele kungasetshenziswa ekudaleni ikhambi elivamile lomdlavuza eminingi.
Umdlavuza uthi nxazonke 10 abayizigidi ezingu uhlala unyaka nonyaka emhlabeni, futhi isabelo saseNdiya cishe silingana 8% salokho. Lezi zinombolo ziyethusa futhi ziyanda minyaka yonke nezindlela ezintsha nobuchwepheshe bokuhlonza umdlavuza kusenesikhathi.
Imininingwane ye-WHO ikhombisa ukuthi i-India inamacala amasha acishe abe yizigidi eziyi-1.2 unyaka ngamunye, futhi angaphezu kwama-50% alawa macala azotholakala kwabesifazane. Umdlavuza wesibeletho inyuke ngamaphesenti angaphezu kwama-39 phakathi kuka-1990 no-2016 futhi iwumdlavuza ovame kakhulu kwabesifazane. Umbiko we-Lancet uqhubeka wenezela ukuthi phakathi kuka-1990 no-2016, isibalo sababulawa umdlavuza eNdiya sanda ngamaphesenti angu-112. Ngesikhathi esifanayo, izigameko zomdlavuza zikhuphuke ngamaphesenti angu-48.7. Lo mbiko uphinde uveze ukuthi ngo-2016, izwe libe neziguli ezinomdlavuza wamaphaphu ezingu-67,000 72.2, okungamaphesenti angama-XNUMX kuzo okungabesilisa, kanti umdlavuza wesibindi iphinde yenyuka ngamaphesenti angama-32.2 kusukela ngo-1990, kwabikwa amacala angu-30,000 2016 ngo-XNUMX.
Ukutholakala okusha ekwelapheni umdlavuza
Kunoma yiluphi uhlobo lokutheleleka, amasosha omzimba aqala ukusebenza futhi asebenze njengesivikelo esingokwemvelo kuwo. Nokho, iphinde ihlasele amangqamuzana omdlavuza. Ososayensi baseCardiff Medical University, eBrithani, bebefuna izindlela ezingajwayelekile nezingakazitholi isimiso somzimba sokuzivikela ezifweni esihlasela ngokwemvelo izimila. Kwatholakala ukuthi kune-t-cell ehlasela futhi ibulale izinhlobo eziningi zamangqamuzana omdlavuza.
Isebenza kanjani le-t-cell ukwelapha umdlavuza?
Ithimba laseCardiff Medical University, eBrithani, lithole i-T-cell kanye ne-receptor yayo engathola futhi ibulale inqwaba yamangqamuzana anomdlavuza elebhu, kuhlanganise nomdlavuza wamaphaphu, umdlavuza wesikhumba, umdlavuza wegazi, umdlavuza wekoloni, umdlavuza webele, umdlavuza wamathambo, umdlavuza wendlala yesinye, umdlavuza wesibeletho, umdlavuza wezinso, namangqamuzana omdlavuza womlomo wesibeletho. Ukuthi lokhu kwenzeka kanjani impela kusazohlolisiswa futhi ososayensi basebenza ngakho.
Lesi samukeli se-T-cell sisebenzisana ne-molecule ebizwa ngokuthi i-MR1, engaphezulu kwawo wonke amaseli emzimbeni womuntu.
Ungahle uthande ukufunda: Ukwelashwa kwe-Car T-cell eNdiya
Kucatshangwa ukuthi i-MR1 ihlaba umkhosi i-metabolism ehlanekezelwe eyenzeka ngaphakathi kweseli elinomdlavuza ukuya emasosheni omzimba.
"Singabokuqala ukuchaza i-T-cell ethola i-MR1 kumangqamuzana omdlavuza-okungakaze kwenziwe ngaphambilini, lena ngeyokuqala yalolu hlobo," umlingani wocwaningo uGarry Dolton utshele iphephandaba. BBC.
Bathini abanye ochwepheshe ngokutholakala kwekhambi lomdlavuza?
ULucia Mori noGennaro De Libero, baseNyuvesi yaseBasel eSwitzerland, bathe lolu cwaningo “lunamandla amakhulu” kodwa kusesekuseni kakhulu ukuthi luzosebenza kuwo wonke umdlavuza.
"Sijabule kakhulu ngemisebenzi yamasosha omzimba yalesi sibalo esisha se-T-cell kanye nokusetshenziswa okungaba khona kwama-TCR abo ekwelapheni kwamaseli esimila," basho.
UDaniel Davis, uprofesa we-immunology eNyuvesi yaseManchester, uthe: “Okwamanje, lolu wucwaningo oluyisisekelo futhi alusondele emithini yangempela yeziguli.
“Akungabazeki ukuthi kuwukutholwa okujabulisa kakhulu, kokubili ekuthuthukiseni ulwazi lwethu oluyisisekelo mayelana namasosha omzimba kanye nethuba lemithi emisha yesikhathi esizayo.”
Ungahle uthande ukufunda: I-CAR T Cell therapy eShayina
