UGeorge D. Demetri kanye nabanye abavela e-American Dana Fabre / Briegen kanye Nesikhungo Somdlavuza Wesibhedlela Sabesifazane babike ukuthi phakathi kweziguli ezine-liposarcoma, ukusetshenziswa kwe-iriprine ekwelapheni okungemuva kuye kwathuthukisa kakhulu izinzuzo zokusinda ngaphezu kwe-dacarbazine. Ezigulini ezine-liposarcoma, into ebaluleke kakhulu ukukhetha ukwelashwa kwe-iribrin, ngoba uhlobo lwe-pathological lwesifo lunomphumela olinganiselwe ekusebenzeni kahle. (J Clin Oncol. Inguqulo ye-inthanethi ka-Agasti 30, 2017)
Ukuhlolwa komtholampilo kwesigaba III sangaphambilini kubonise ukuthi i-irribrin uma iqhathaniswa ne-dacarbazine ekwelapheni i-liposarcoma ethuthukisiwe noma i-leiomyosarcoma ingathuthukisa kakhulu ukusinda okuphelele (OS), futhi ukusabela okubi kulula ukuphatha nokulawula. Manje abacwaningi benza ukuhlaziywa kweqembu elingaphansi kwesimo seqembu le-iribulin neqembu le-dacarbazine, ngenhloso yokucacisa ukucaciswa kwezicubu ezifanele nokuphepha.
Izimo zokubhalisa: iminyaka yesiguli ≥18 iminyaka; i-liposarcoma ethuthukisiwe noma ethuthukisiwe engelapheka ngokuhlinzwa noma nge-radiotherapy; Isikolo sesimo sokusebenza se-ECOG ≤2; imithi yangaphambili ye-chemotherapy ≥2, kuhlanganise ne-anthracycline. Iziguli zahlukaniswa ngokungahleliwe zaba yiqembu le-erebrin (1.4 mg / m2, d1, 8) noma iqembu le-dacarbazine (850 mg / m2, 1000 mg / m2, noma 1200 mg / m2, d1) ngesilinganiso esingu-1: 1. Izinsuku ezingama-21 ziwumjikelezo. Amaphoyinti okufunda afaka i-OS, i-progression-free survival (PFS), nokuphepha.
Imiphumela yabonisa ukuthi i-OS eqenjini elincane le-liposarcoma yathuthukiswa kakhulu. I-OS emaphakathi emaqenjini e-iribulin nawe-dacarbazine yayiyizinyanga ezingu-15.6 nezinyanga ezingu-8.4 ngokulandelanayo (HR = 0.51, 95% CI 0.35 ~ 0.75; P <001). Eqenjini le-iribulin, iziguli ezine-liposarcoma yazo zonke izinhlobo ze-histological neziguli kuzo zonke izifunda zithole ukuthuthukiswa kwe-OS. I-PFS emaphakathi yeziguli eqenjini le-erebrin yayiyizinyanga ezingu-2.9 nezinyanga ezingu-1.7 ngokuhlobene neqembu le-dacarbazine (HR = 0.52, 95% CI 0.35 ~ 0.78; P = 0.0015). Izenzakalo ezimbi zazifana phakathi kwamaqembu amabili.
