Thola ukuthi i-immunotherapy ingaba kanjani umngane wakho weqiniso ekushayeni i-myeloma! Ibhulogi yethu inikeza imininingwane elula emandleni e-immunotherapy ye-myeloma eminingi. Ungaphuthelwa yilesi sisetshenziswa ukuze uthole impi enamandla kakhulu, enolwazi olwanele ne-myeloma. Kungukhiye wakho wokuqonda nokubhekana nempi ngokuzethemba nethemba.
Siyakwamukela ekuhloleni okuphelele kwe "I-Immunotherapy ye-Multiple Myeloma” – esebenza njengesikhali esimangalisayo sokulwa nomdlavuza.
I-myeloma eminingi, uhlobo lomdlavuza wegazi osuka kumangqamuzana e-plasma, lunikeza izinselele eziyingqayizivele ezindleleni zokwelashwa zendabuko.
Le bhulogi ilapha ukuze ikusize uqonde okwengeziwe ngalokhu umdlavuza wegazi futhi sikwethule ngokwelashwa okusha nokwethembisayo okubizwa nge-immunotherapy.
Sizoqala ngokuchaza ukuthi iyini i-myeloma eminingi, ukuthi ibathinta kanjani abantu, nokuthi ithuthuke kangakanani ukwelashwa kwe-myeloma eminingi eNdiya kwenza umehluko omkhulu endleleni esilwa ngayo nomdlavuza.
I-Immunotherapy iwukwelashwa okuyiqhawe, futhi namuhla sizobheka ukuthi isebenza kanjani futhi sizwe kanjani izindaba kwabantu abahlomule kuyo.
Ngakho-ke hamba nathi njengoba sihlola umhlaba we-myeloma eminingi futhi sibone ukuthi i-immunotherapy ilinikeza kanjani ithemba futhi iletha izinguquko ezinhle endleleni esiphatha ngayo lesi simo esinzima.
Ngaphakathi Emhlabeni Womdlavuza Wegazi: Iyini I-Multiple Myeloma?
I-Multiple myeloma wuhlobo lomdlavuza oluqala egazini lakho. Kwenzeka lapho amangqamuzana athile akhethekile aziwa ngokuthi amangqamuzana e-plasma ehluleka ukusebenza kahle.
Ngokuvamile, amangqamuzana e-plasma asiza umzimba wakho ukulwa namagciwane ngokwenza amasosha omzimba. Kodwa ku-myeloma eminingi, lawa maseli ahluphayo akha emathanjeni akho futhi abangele izinkinga.
Lamangqamuzana ayingozi athatha isikhala emnkantsheni, okungaphakathi okuthambile emathanjeni akho lapho kukhiqizwa khona amangqamuzana egazi.
Adudula amangqamuzana amahle, futhi esikhundleni sokukhiqiza amasosha omzimba awusizo, akhiqiza amaprotheni angasebenzi kahle. Lokhu kubangela i-myeloma eminingi futhi kukwenza ungaphatheki kahle.
I-Myeloma Eningi Ikuthinta Kanjani Impilo Yakho?
I-Myeloma eminingi ingaba nomthelela omkhulu enhlalakahleni yakho ngezindlela ezihlukahlukene. Nakhu okufingqiwe kokuthi lo mdlavuza ungakuthinta kanjani:
Ubuhlungu Bamathambo Nokuphuka
Isistimu Yamasosha omzimba Ebuthakathaka
Ukukhathala
I-anemia
Izinkinga Zezinso
Izinkinga Zesistimu Yezinzwa
Umthelela Empilweni Yengqondo
Iyini I-Immunotherapy?
I-Immunotherapy iyindlela yokwelapha yomdlavuza emangalisayo esebenzisa amasosha omzimba ukufuna nokubhubhisa amangqamuzana omdlavuza. Amasosha akho omzimba ayakwazi ukubona nokukhipha izihlaseli ezifana nomdlavuza.
I-Immunotherapy ye-myeloma isebenza njenge-booster shot, ithuthukisa amandla amasosha omzimba okuthola nokubhubhisa iseli le-myeloma. Lolu hlobo lokwelashwa komdlavuza lubonise ukusebenza okuphawulekayo, luthembisa impilo ende ezigulini eziningi ezinomdlavuza.
Ngaphezu kwalokho, intuthuko yamanje ocwaningweni lwezokwelapha iyaqhubeka nokwethula izindlela zokwelapha ezintsha ze-immunotherapy ezifana - ukwelashwa kwe-t cell therapy eNdiya.
Kafushane nje, i-immunotherapy ifana nokuqinisa izivikeli zakho zemvelo, isiza umzimba wakho ukuba ulwe nezifo ezimbi ngendlela ehlakaniphile nenamandla.
Yiziphi Izinhlobo Ze-Immunotherapy Ye-Multiple Myeloma?
I-CAR-T Cell Therapy:
I-CAR T-cell therapy iwukwelashwa komuntu siqu kwe-myeloma immunotherapy okubandakanya ukukhipha ama-T cell esiguli (uhlobo lwengqamuzana lokuzivikela ezifweni), ukuwaguqula elabhorethri ukuze aveze iseli ye-chimeric antigen receptor t eqondisa ngokukhetha amangqamuzana omdlavuza, bese iwabuyisela kabusha. abuyele esigulini.
Izindaba ezimnandi ukuthi izindleko zokwelashwa kwe-CAR T Cell eNdiya incane uma iqhathaniswa nezinye izizwe emhlabeni. Izinketho ezimbili ze-car t cell immunotherapy ye-myeloma eminingi sezivele zigunyazwe yi-FDA.
Ama-immunomodulatory agents:
Le mishanguzo eminingi ye-myeloma immunotherapy iyingxenye ebalulekile yokwelashwa kwe-myeloma eminingi, futhi isebenza ngokushintsha impendulo yomzimba ye-immunological.
Le mishanguzo ayiqondi kuphela ngokuqondile kumaseli omdlavuza kodwa iphinde ibe nomthelela endaweni encane ezungezile ukuze iyenze ibe nokungenisa izihambi kancane ekukhuleni kwamaseli e-myeloma.
Le mithi isiza ukunciphisa ukuqhubeka kwe-myeloma eminingi futhi ithuthukise imiphumela yokwelashwa iyonke ngokuthonya impendulo yokuzivikela komzimba.
Uma i-myeloma yomuntu iphindelela noma ingaphenduli kahle kwezinye izindlela zokwelapha, le mithi isengaba nenzuzo kakhulu.
Ama-Checkpoint Inhibitors:
I-Checkpoint inhibitors wuhlobo lwe-immunotherapy olusebenza ngokuvimbela amaprotheni athile ebusweni bamasosha omzimba noma amangqamuzana omdlavuza. Ama-Checkpoint inhibitors asebenza njengezilawuli zethrafikhi zamasosha omzimba.
Angakwazi ukuvimba amasiginali abambezela ukusabela kwethu kwamasosha omzimba noma enze izimpawu eziwuqinisayo zisebenze.
Lokhu kuvumela imizimba yethu ukuthi iqonde kangcono futhi ihlasele amaseli amaningi e-myeloma ngenkathi ivikela amaseli anempilo. Ososayensi bahlola lawa ma-inhibitors ovivinyweni lwe-immunotherapy lwe-myeloma eminingi, futhi imiphumela yokuqala ikhombisa ukuthi banesithembiso esikhulu.
Ama-Antibodies e-Monoclonal:
Amasosha omzimba e-Monoclonal amamolekyuli enziwe elabhorethri aphindaphinda amandla amasosha omzimba okulwa namagciwane ayingozi namabhaktheriya. Ososayensi bathole indlela yokwenza amasosha omzimba okwenziwa elebhu.
Lawa masosha omzimba adalwe ilebhu angathuthukisa izivikelo zethu zemvelo, azivumele ukuthi ziqonde kangcono futhi zihlasele amaseli e-myeloma. Lokhu kwelashwa kwe-myeloma eminingi kusiza ekwehliseni inani lamangqamuzana anomdlavuza nokulawula ukuqhubeka kwesifo.
Umthelela Omuhle We-Immunotherapy Empilweni
I-Immunotherapy ku-myeloma iletha ithemba elisha ezimpilweni zeziguli eziningi. Ake sibone ezinye zezinzuzo zayo ezinkulu -
I-Immunotherapy ingathuthukisa ikhono lomzimba lokuhlonza nokubhubhisa amangqamuzana anomdlavuza, ithuthukise ukusebenza kahle kokwelashwa.
I-Immunotherapy ngokuvamile iholela emiphumeleni emibi kakhulu uma iqhathaniswa nokwelashwa okuvamile okufana nokwelashwa ngamakhemikhali.
Nge-immunotherapy, ezinye iziguli ziba nokuxolelwa okuhlala isikhathi eside noma ukululama ngokuphelele, okunikeza ithemba lempilo ende nenempilo.
I-Immunotherapy ithuthukisa impilo yonke yesiguli somdlavuza kanye nekhwalithi yokuphila ngokunciphisa ubunzima bemiphumela emibi.
I-Immunotherapy Ibhala Kanjani Indaba Yempilo Yomuntu Osinde Ngomdlavuza?
UBjørn Simonsen, 67, ubhekane nohambo oluyinselelo nge-myeloma eminingi. Ngemuva komzuliswano wokuqala we-chemotherapy, ukuphindeka kabusha ngo-2021 kwaholela ekwelashweni okungaphumelelanga.
Waya esibhedlela iLu Daopei ngoFebhuwari 2022 ukuze athole ukwelashwa ngamaseli e-CART. Ukulandela ukulungiswa nge-fludarabine ne-cyclophosphamide, amaseli e-CART ajovwe.
Nakuba ayenomkhuhlane we-neutropenia, isende lakhe langakwesokudla kancane kancane labuyela esimweni esivamile. Ngosuku lwama-28, ukuhlolwa komnkantsha akuzange kubonakale amaseli e-plasma.
UMnu. Simensen ukhululwe ngokuhlelwa kokulandelela okuhleliwe, futhi isipiliyoni sakhe siqokomisa ukuthi ukwelashwa kwamaseli e-CART kungasetshenziswa kanjani ukwelapha iziguli ezine-myeloma ephindaphindiwe ne-refractory.
Le ndaba yempumelelo eminingi ye-myeloma immunotherapy isifundisa ukubaluleka kokuzimisela okuqinile, umcabango omuhle, namandla okwelashwa komdlavuza okuqhubekayo.
Imicabango Final
Njengoba ubhekene nenselele ye-myeloma, khumbula lokhu: Ufana nesosha elinesibindi empini yokuphila. Noma izinto zizwakala zinzima, indlela entsha yokwelashwa kwe-immunotherapy ye-myeloma eminingi isikhona ukuzosiza.
Kuyindlela efanele ohambweni lwakho lokulwa nokusinda komdlavuza. Ngakho-ke, qhubeka, futhi uvumele lokhu kwelashwa kukuholele empilweni enempilo nejabulisayo.
Uma unemibuzo mayelana nalokhu kwelashwa, zizwe ukhululekile ukusishayela noma nini. Singakuxhumanisa nesikhungo somdlavuza esihamba phambili esihlinzeka ngemithi ethuthuke kakhulu ye-immunotherapy.
