Ukudla "kudla" umdlavuza onemibala
Ngo-2014, uMnu uYang oneminyaka engu-65 nomkakhe bahambela phesheya. Phakathi nalesi sikhathi, kwaba khona ukungaphatheki kahle kwamathumbu kanye nezimpawu zokuqunjelwa, kepha kabazange banake kakhulu ngaleso sikhathi, becabanga ukuthi abanelisekile ngomhlabathi namanzi. Ngemuva kokubuyela eChina, izimpawu zancipha kancane kancane.
On National Day in 2014, when his son, daughter-in-law, and grandson went home for the holiday, Mr. Yang suddenly had nausea and vomiting when he went to the restaurant to eat. Everyone quickly took him to a nearby large hospital for an examination. Immediately apply for hospitalization.
However, even greater bad news fell from the sky. Further examination showed that Mr. Yang had not appendicitis but umdlavuza colorectal.
NgoNovemba, uMnu. Yang waphinda wathola i-laparoscopic resection ye-semicolon efanele. Imvamisa, ukubikezelwa komdlavuza onombala ohlangothini lwesokunene kubi kakhulu kunalokho ohlangothini lwesobunxele, kodwa ngenhlanhla, uMnu. Yang wakuthola ngokushesha futhi ukuhlinza kwakushelelezi kakhulu. I-pathology ikhombisa ukuthi yisigaba II, esisekuqaleni.
Ngemuva kokuhlinzwa, uMnu. Yang wabuyela empilweni ejwayelekile ngemuva kokuphumula.
Chemotherapy is not effective, the genetic test is negative, is there any help for advanced colorectal cancer?
In May 2016, Mr. Yang clearly felt that he was always tired and fatigued. Sure enough, CT review showed nodules in the anastomosis of the previous operation. Further examination confirmed the recurrence of colorectal cancer and the metastasis of peritoneum and lymph nodes.
He immediately received the FOLFIRI ± cetuximab regimen, but the effect was not satisfactory. Under the advice of the doctor, he conducted a genetic test, and now there are many targeted and immunotherapy izidakamizwa emakethe. Uma kukhona ukuguquka, kungenzeka ukuthi kukhona Uhlaka lwesiliva. Noma kunjalo, imiphumela yayidumaza. Uhlolo alutholanga ukuguqulwa okunengqondo, futhi i-microsatellite izinzile, okusho ukuthi izivikeli mzimba zokuhlola izivikeli mzimba ezithathwa njengezithutha ezisindisa impilo zeziguli ezinomdlavuza azikwazi ukusetshenziswa.
Umuthi wokugomela i-dendritic cell ususa zonke izilonda
Just when the whole family was in despair, a friend in the medical circle recommended Mr. Yang to go to Japan to try dendritic cell vaccine treatment.
This is a dendritic cell vaccine that specifically identifies cancer cells in patients by extracting their own tumor cell antigens, because this is an advanced cell immunotherapy, has no side effects, and even cooperates with normal chemotherapy and targeted therapy Can also increase the effect.
I asked the attending doctor in China, and it was also recognized. The doctor said that although it is impossible to cure, Japan’s cell immunotherapy is indeed at the global leading level. If the economic conditions allow, you can try to achieve the purpose of prolonging survival and improving the quality of life.
Ngo-Agasti 2016, uMnu. Yang nomkakhe bafika eJapan.
Odokotela baseJapan baqale benza ukuhlolwa okuphelele kokusebenza komzimba wakhe bathola ukuthi inani lamaseli T emzimbeni lincane kakhulu, okusho ukuthi amandla omzimba okubulala amangqamuzana omdlavuza awanele. Inani lalokhu lizosiza ukwelashwa ngamakhemikhali nokwelashwa kokugomela kamuva i-dendritic, ngenkathi kudonswa igazi ukulungiselela imishanguzo yamaseli e-dendritic.
Ngokushesha ngemuva kokuqeda ukuhlanganiswa kabusha kokuqala, umuzwa kaMnu. UYang osobala kakhulu ukuthi wayezizwa egcwele amandla emzimbeni wakhe. Wayehlala ezizwa ebuthakathaka futhi ebuthakathaka, futhi izimpawu zobuhlungu zancipha. Ngokudla, wayengadla ukudla okulula. ukudla.
Ngo-Okthoba 2016, uMnu. Yang waqala ukujoyina ukwelashwa komuthi wokugoma i-dendritic cell kanye njalo emavikini amabili.
NgoJanuwari 2017, imiphumela yokuhlolwa kwe-PET yamangaza wonke umuntu, futhi izilonda eziphindaphindekayo zanyamalala.
NgoJanuwari 2018, imiphumela yokuhlolwa kabusha kukaMnu. Yang iphinde yabonisa ukuxolelwa okuphelele, futhi izilonda emzimbeni zisuswe ngokuphelele.
Njengamanje, uhlelo lokwelashwa lukaMnu. Yang luyalungiswa ukuze lubuye kanye ezinyangeni eziyisithupha ukuvimbela ukuphindeka. Kuze kube manje, uMnu Yang usesimweni esihle futhi ubuyele empilweni ejwayelekile.
Kuyini ukwelashwa kokugomela amaseli e-dendritic?
After reading Mr. Yang’s case, I believe that many patients who are not effective for chemotherapy and whose genetic testing does not have targeted drugs see hope.
Dendritic cell vaccine is an ideal therapy. We all know that one of the reasons for the formation of cancer is that cancer cells hide very well. Dendritic cells cannot recognize cancer cells. Imagine that you can put your own cancer cells and dendrites. The cells are fused to form dendritic cells that carry specific antigens on the surface of various cancer cells. These dendritic cells have the ability to recognize isisu cells. When we put these cells back into the conductor, he will teach somatic cells to recognize different Cancer antigen cancer cells, one group to find a antigen, one group to find b antigen cancer cells, all of them are eliminated, and at the same time used in combination with the adjuvant therapy of interleukin 12, which enhances T cells in the body, can effectively increase killer T cells The number, so as to achieve the best anti-cancer effect.
Izinzuzo ezintathu zemithi yokugoma yamaseli e-dendritic
1. Kususelwa ekwakhiweni kabusha kwamaseli omzimba okuhleliwe okucacile kakhulu, kuhloswe kakhulu, kunembile futhi kusebenza kahle ekususweni kwamangqamuzana omdlavuza.
Ukuvela kwezifo ezehlukene ezithathelwanayo ezibangelwa amagciwane kanye nezicubu zomzimba kuhlobene ngqo nokulahleka noma ukukhubazeka komsebenzi we-DC womzimba, ngakho-ke ukubuyisela umsebenzi othile we-DC emzimbeni kuba yisihluthulelo sokwelashwa nokuvinjelwa kwezifo ezinjalo. Ngenxa yokusetshenziswa kwama-pepitide e-epitope akhethekile, i-T-DC yenza amaseli we-T acushiwe acaciswe futhi aqondiswe, futhi alungise, abuyisele futhi athuthukise ukusebenza kwamaseli omzimba wesiguli, ephula amasosha omzimba nokubekezelelana kwasendaweni okwamukela, ukuze kuzuzwe ukwakhiwa kabusha komzimba wonke nokuzivikela komzimba wendawo.
2. Qhubeka nokuqala indlela yokususa nge-non-cytolysis njengemodi yokubulala eyinhloko, ngokuphepha okuphezulu
Ucwaningo lukhombisile ukuthi i-T-DC isebenzisa kakhulu ukuhlanganisa ama-cytokines ahlukahlukene emzimbeni njengezindlela eziyinhloko zokususa umgomo, okwenza amasosha omzimba abuyiselwe anciphise kakhulu ukulimala kwamaseli ajwayelekile ngenkathi kususwa inhloso.
3. Inomphumela wesikhathi eside wezimpawu zokugoma futhi ibona inhlanganisela yemvelo yokuvikela nokwelashwa
I-DC eyakhiwe kabusha nge-in vitro ingenza kusebenze amaseli we-T asele ukukhiqiza impendulo yokuqala yomzimba lapho iphinda ifakwa emzimbeni, futhi amaseli we-T acushiwe angakhuliswa futhi aqhubeke andiswe. I-dendrite eyodwa ingenza kusebenze amaseli we-100-3000 T. Amaseli amaningi we-T asebenza indima ekususeni amagciwane, kanti enye ingxenye izosinda amashumi eminyaka kuya kumashumi eminyaka ukuze ibe ngamaseli we-memory T. Ngokuzayo lapho bevezwa ama-antigen omthamo ophansi, impendulo yamasosha omzimba ephezulu kakhulu. Ngakho-ke, uhlelo lokuvikela omzimba olususelwa ekulungisweni nasekuvuseleleni kabusha kwe-T-DC lungaqhubeka nokusebenza amashumi eminyaka, futhi lungaphinda lungene emjikelezweni ukuze lusebenze ngaphansi kwezimo ezifanele.
Yiziphi iziguli ezinomdlavuza ezingathola ukwelashwa kokugomela amaseli e-dendritic?
Kumele kuqashelwe ukuthi ukwelashwa kokugomela amaseli e-dendritic akunamthelela osobala ekunciphiseni isimila seziguli ezinomdlavuza osezingeni eliphezulu, kanti iziguli ezinomdlavuza osezingeni eliphakeme zinomphumela wokwelula impilo ngenkathi zigcina ikhwalithi yempilo; njengokwelashwa okunciphisayo ngemuva kokuhlinzwa, kungacindezela ukubuyela emuva futhi kuphathe Umphumela ungagcinwa isikhathi eside; kuhlanganiswe nezinye izindlela zokwelapha ezinjenge-chemotherapy, izidakamizwa ezihlosiwe, ama-PD1 inhibitors, umphumela uzoba ngcono. Ngakho-ke, lezi zinhlobo ezinhlanu zeziguli zifaneleke kakhulu:
- Iziguli ezinomzimba omubi ngaphambi kokuhlinzwa kwesimila, ukululama kancane ngemuva kokuhlinzwa, nokwesaba amaseli omdlavuza wemilingo ukuthi akuqediwe ngokuphelele.
- After radiotherapy and chemotherapy, immunity is low, and side effects are obvio
thina (njengokulahlekelwa isifiso sokudla, isicanucanu, ukulahleka kwezinwele, ukuvuvukala kwesikhumba, njll.), iziguli ezilindele ukwandisa umphumela we-chemoradiation. - Ngenxa yokwesaba imiphumela emibi ye-radiotherapy kanye ne-chemotherapy, iziguli ezinethemba lokusebenzisa izindlela ezahlukahlukene zokwelapha ukufeza imiphumela yokwelashwa.
- Amaseli womdlavuza kwizicubu ezisezingeni eliphakeme asabalale wonke umzimba, kepha izindlela zokwelashwa ezivamile azinamandla, futhi iziguli ezilindele ukwelula isikhathi sokuphila nokwenza ngcono impilo.
- Iziguli ezithola amasosha omzimba okuhlola izivikeli mzimba.
Mainly applicable to solid tumors: head and neck tumors, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, pancreatic cancer, colorectal cancer, ovarian cancer, umdlavuza wesibeletho, renal cancer, prostate cancer, malignant melanoma, sarcoma, partial malignancy Lymphoma.
Iziguli ezifuywayo zikuthola kanjani ukwelashwa kokugomela amaseli e-dendritic?
Njengamanje, awekho amaphrojekthi amaningi wezivivinyo zomtholampilo avunyelwe i-immunotherapy yeselula e-China, futhi inani, ukuphepha kanye namandla we-DC cell therapy kusamele athathwe. Kukholakala ukuthi uma le nqubomgomo isiyethuliwe ngokuphelele, izoshayela ukuqaliswa kokusebenza kwamazinga kanye namazinga asebenzayo e-China nokwengeza izindlela ezintsha zokwelashwa kweziguli ezinomdlavuza eChina. E-United States, eJalimane, eJapan nakwamanye amazwe anezindinganiso zokwelashwa ezithuthukisiwe, ukuthuthukiswa kanye nokusetshenziswa komtholampilo kwamaseli we-dendritic kuhamba phambili emhlabeni. Imithi yokugoma yamaseli e-dendritic eJalimane naseJapane ithuthukiswe ngempumelelo futhi yafaka isicelo somtholampilo. Ungahlola futhi usebenzise nge-Global Oncologist Network (+91 96 1588 1588).
Kumele kuqashelwe ukuthi umphumela we-cell immunotherapy ekunciphiseni kwezicubu ezigulini ezinomdlavuza osezingeni eliphezulu awubonakali. Ezigulini ezinomdlavuza osezingeni eliphezulu, zinomphumela wokwelula impilo ngenkathi zigcina ikhwalithi yempilo; njengokwelashwa okunciphisayo ngemuva kokuhlinzwa, kungacindezela ukubuyela emuva kanye nomphumela wokwelapha Gcina isikhathi eside; kuhlanganiswe nokwelashwa ngamakhemikhali, izidakamizwa ezihlosiwe, ama-PD1 inhibitors nezinye izindlela zokwelapha, umphumela uzoba ngcono.
Cellular immunotherapy is not suitable for all cancer patients. For example, the i-sarcoma of Wei Zexi is a rare tumor with a high degree of malignancy. There is currently no good treatment in the world. Therefore, cell immunotherapy is naturally not suitable. Therefore, please ensure that you, family members and patients are kept away from false information on the Internet. Before choosing treatment, it must be evaluated by experts in formal and authoritative cancer hospitals. It is very important to choose carefully according to the economic conditions of the family.
