A study conducted at the Los Angeles Children ‘s Hospital is providing the best treatment for a rare invasive leukemia called mixed phenotype acute leukemia (MPAL).
Lolu cwaningo (ukuhlanganiswa kobuningi beminyaka engu-20 yezincwadi zesayensi) luthole ukuthi ukwelashwa kwe-MPAL ngohlelo olunobuthi obuphansi kuhlotshaniswa nenzuzo ecacile yokuxolelwa kanye nokuphila okungaba khona isikhathi eside. Lokhu okutholakele kushicilelwe kujenali eku-inthanethi ethi “Leukemia” ngoFebhuwari 27, 2018.
MPAL accounts for 2% -5% of leukemia cases, which is historically difficult to treat, and the 5-year survival rate is less than 50%. The disease affects children and adults and is characterized by two common forms of leukemia: acute lymphocytic leukemia (ALL) and I-acute myeloid leukemia (AML).
Udokotela kufanele anqume ukuthi uzosebenzisa KONKE noma i-AML, noma inhlanganisela yalezi zindlela ezimbili. Akukho ukuvumelana okucacile ngokuthi iyiphi indlela engcono kakhulu. Ngoba lesi sifo siyivelakancane, izinkulungwane zeziguli azihlolwe emtholampilo ukuthola uhlelo oluhle kakhulu lokwelashwa. Esikhundleni salokho, kuye kwakhishwa imibiko eminingi emincane, ehlukanisiwe, futhi evame ukuphikisana emamagazini asakazwa kabanzi emhlabeni wonke.
Ukuze uqonde kangcono ucwaningo olukhona futhi unikeze odokotela umhlahlandlela ocacile wokwelashwa, u-Orgel nethimba labacwaningi be-CHLA benze ukubuyekeza okuhlelekile kokuqala kokuhlola kanye nokuhlaziywa kwe-MPAL. Ithimba ligcine linciphise uhlu lwaba ngamaphepha ahlobene angama-252 avela emazweni angama-33, afaka iziguli eziyi-1,499. Ukuthola kwabo okubalulekile: Iziguli ezazelashwa kuqala ZONKE (iziguli ezinobuthi obuphansi kakhulu) zazinamathuba ama-3 kuye kwayi-5 okuthola ukukhululwa okuphelele kuneziguli ezazelashwa nge-AML. Iziguli ezithola ukwelashwa okuxubekile zenze kabi kakhulu.
The study highlights the important need for clinical trials to determine the best treatment for MPAL and helps promote the treatment of this rare disease.
