Ucwaningo lwakamuva olushicilelwe kumagazini i-Cellular and Molecular Gastroenterology and Hepatology lubonise ukuthi ukuguqulwa kofuzo okubizwa ngokuthi i-ATRX kungase kubangele ingozi eyengeziwe ye-pancreatitis kanye nomdlavuza we-pancreatic kwabesifazane. Lolu cwaningo lumaka ukutholakala kokuqala kwezici zobungozi eziqondene nocansi zomdlavuza wepancreatic.
The team used a preclinical model to examine the effect of ATRX mutations on the adult pancreas. They deleted the ATRX gene and then studied its effect on umdlavuza pancreatic susceptibility. The team found that the deletion of the ATRX gene in women increased the susceptibility to pancreatitis-related pancreatic damage and accelerated the progression of pancreatic cancer. Emadodeni, ukuguqulwa kwe-ATRX akubunyusi ubungozi bokulimala kwepancreatic, futhi empeleni kunciphisa ukukhula komdlavuza wepancreatic.
The team ‘s preclinical results were compared with human samples from the International Cancer Genome Alliance database, which includes whole-genome sequence analysis of 729 patients. Ithimba labacwaningi lithole ukuthi iziguli ezingama-19% zithwala ukuguquka kobude besakhi sofuzo i-ATRX, kufaka phakathi izifunda ezingabhalisi amakhodi, ezingama-70% ezabesifazane. Yize ukuguquka kwezinguquko okuningi kubonakala kungaphazamisi ukulandelana kwamaprotheni we-ATRX, izinguquko ezibikezelwe ukuthinta umsebenzi we-ATRX zenzeka cishe kuphela kwabesifazane.
Usosayensi kanye noprofesa osebenzisana noLawson uDkt Chris Pin uthe, “Umdlavuza wepancreatic yisifo esibuhlungu kakhulu esivame ukutholakala sesisesigabeni esithuthukile. Iziguli imvamisa aziphenduli ekwelashweni okukhona, kanti ubude besikhathi sokuphila seziguli ngemuva kokuxilongwa Ngaphansi kwezinyanga eziyisithupha. “I-Pancreatitis yisifo esivezwa wukuvuvuka kwamanyikwe futhi okungenye yezinto ezibaluleke kakhulu ekubhekaneni nomdlavuza wepancreatic. Yize kudingeka olunye ucwaningo, abesifazane abane-pancreatitis ngelinye ilanga bangakhonjwa njengeqembu elisengozini enkulu, futhi lokhu kuguqulwa kofuzo kufanele kuhlolwe.
In a follow-up study, Dr. Pin will work with French researchers to study patient isisu samples in a new preclinical model. Their goal is to better understand the mechanism of ATRX mutations as a gender-specific risk factor. In order to develop better diagnosis and treatment methods for women carrying this mutation.
