UDkt. Edwin P. Alyea

UDkt. Edwin P. Alyea ugxile ekwelapheni iziguli ezinomdlavuza wegazi ezicabangela ukufakelwa i-stem cell noma umnkantsha. Eminyakeni engu-20 edlule, kube nentuthuko enkulu ekufakeni izithombo, okube nemiphumela engcono. Le ntuthuko ihlanganisa amandla okusebenzisa imithamo ephansi ye-chemotherapy ukuze kwehliswe ubuthi ezigulini, kanye nezindlela zokunciphisa amathuba okuphinda aqubuke. Ngithanda ukusebenzisa imithi emisha kanye nezindlela zokuthuthukisa imiphumela kulandela ukufakelwa kwe-stem cell ngenxa yezifo ezimbi zegazi. Kubalulekile ukubambisana neziguli ukuze uchaze imigomo yazo yokwelashwa kanye nesinyathelo esingcono kakhulu. Iminyaka eminingi ngemva kokufakelwa kwabo, bengikuthanda ukusebenza neziguli nemindeni yazo.

Isitifiketi seBhodi

Ibhodi laseMelika le-Internal Med, Medical Oncology

Fellowship

I-Medical Oncology, i-Dana-Farber Cancer Institute (Massachusetts), 1992-1995

Indawo yokuhlala

Imithi Yangaphakathi, iBrigham kanye Nesibhedlela Sabesifazane (Massachusetts), 1989-1992

Imfundo

MD, Duke University, 1989

• I-Adult Bone Marrow kanye ne-Stem Cell Transplant
• Ukufakelwa kwe-Autologous
• Ukufakelwa kwe-Allogeneic
• I-Syngeneic Transplant

• Hourigan, Christopher S., Laura W. Dillon, Gege Gui, Brent R. Logan, Mingwei Fei, Jack Ghannam, Yuesheng Li, et al. “Impact of Conditioning Intensity of Allogeneic Transplantation for I-Acute Myeloid Leukemia With Genomic Evidence of Residual Disease.” J Clin Oncol 38, nxa. 12 (April 20, 2020): 1273–83. https://doi.org/10.1200/JCO.19.03011.
• Soiffer, Robert J., Haesook T. Kim, Joseph McGuirk, Mitchell E. Horwitz, Laura Johnston, Mrinal M. Patnaik, Witold Rybka, et al. “Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.” J Clin Oncol 35, no. 36 (Disemba 20, 2017): 4003-11. https://doi.org/10.1200/JCO.2017.75.8177.
• Liu, Hien Duong, Kwang Woo Ahn, Zhen-Huan Hu, Mehdi Hamadani, Taiga Nishihori, Baldeep Wirk, Amer Beitinjaneh, et al. “Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia.” I-Biol Blood Marrow Transplant 23, no. 5 (May 2017): 767-75. https://doi.org/10.1016/j.bbmt.2017.01.078.
• Scott, Bart L., Marcelo C. Pasquini, Brent R. Logan, Juan Wu, Steven M. Devine, David L. Porter, Richard T. Maziarz, et al. “Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes.” J Clin Oncol 35, nxa. 11 (April 10, 2017): 1154–61. https://doi.org/10.1200/JCO.2016.70.7091.
• Shaffer, Brian C., Kwang Woo Ahn, Zhen-Huan Hu, Taiga Nishihori, Adriana K. Malone, David Valcárcel, Michael R. Grunwald, et al. “Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome.” J Clin Oncol 34, no. 16 (Juni 1, 2016): 1864-71. https://doi.org/10.1200/JCO.2015.65.0515.
• Devine, Steven M., Kouros Owzar, William Blum, Flora Mulkey, Richard M. Stone, Jack W. Hsu, Richard E. Champlin, et al. “Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502.” J Clin Oncol 33, no. 35 (Disemba 10, 2015): 4167-75. https://doi.org/10.1200/JCO.2015.62.7273.
• Jacobson, Caron A., Lixian Sun, Haesook T. Kim, Sean M. McDonough, Carol G. Reynolds, Michael Schowalter, John Koreth, et al. “Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease.” I-Biol Blood Marrow Transplant 20, no. 5 (May 2014): 668-75. https://doi.org/10.1016/j.bbmt.2014.01.021.
• Cutler, Corey, Haesook T. Kim, Bhavjot Bindra, Stefanie Sarantopoulos, Vincent T. Ho, Yi-Bin Chen, Jacalyn Rosenblatt, et al. “Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial.” Igazi 122, no. 8 (Agasti 22, 2013): 1510-17. https://doi.org/10.1182/blood-2013-04-495895.
• Porcheray, Fabrice, David B. Miklos, Blair H. Floyd, Stefanie Sarantopoulos, Roberto Bellucci, Robert J. Soiffer, Joseph H. Antin, Edwin P. Alyea, Jerome Ritz, and Emmanuel Zorn. “Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation.” Ukufakelwa kwezitshalo 92, nxa. 3 (Agasti 15, 2011): 359-65. https://doi.org/10.1097/TP.0b013e3182244cc3.