Ucwaningo olusha luchaza ubudlelwano be-themechanistic phakathi kwe-thecytokine interleukin-1β(IL-1β) nokukhuluphala. Lapho amazinga e-IL-1β enyuka ekukhuluphaleni, ukwenziwa kusebenze kokusayina kwe-IL-1receptor kuholela enanini elikhulu lomdlavuza wamakholoni. Izinhlobo zezindlela. Lolu cwaningo lubonisa ukuthi ukukhuluphala kuhlobene nokwenyuka kwesistimu ye-IL-1β, ukwenziwa kusebenze kwe-W kanye nokwanda kwamaseli ekholoni yegundane.
UJoel Mason waseTufts University eMassachusetts naseTufts University School of Medicine nozakwabo baseTufts University babhale lo mbhalo “Interleukin- 1 Signaling Mediates Obesity-Promased Upened Inflammatory Cytokines, Wnt Activation, and Small” Proliferation of rat colonic epithelial cell ”isihloko . "
The researchers set out to determine the role of IL-1β in regulating events leading to obesity-promoting umdlavuza colorectal. They compared the role of IL-1β in mice fed a high-fat (obese) or low-fat (lean) diet. One of the changes they are found in obese mice having colon mucosa 30-80 % higher concentration of IL-l [beta] , the Wnt cascade significantly increased signal amplification and significantly proliferating crypts in the colon region.
"Lolu cwaningo luveza ukuxhumana okusondelene phakathi kokukhuluphala nokuphendula okuvuthayo, futhi kukhombisa iqhaza elibanzi le-IL-1β, elichaza ukukhuluphala njengesinye sezifo eziningi zokuvuvukala," uMnyango Wezokuvikela, iWashington University, iCentre for Innate Immunity and Immune Diseases. UMichael Gale Jr., ongumhleli-omkhulu we-Journal of Interferon & Cytokine Research, uthe.
