Inguquko I-CAR T Cell Therapy kushintsha isimo sendlela esibhekana ngayo nomdlavuza, siwenza ube ngumuntu siqu futhi ube namandla. Lokhu kwelashwa kwakamuva kusebenzisa amangqamuzana omzimba esiguli futhi siwaguqule ngokofuzo ukuze aqondise futhi abhubhise amaseli omdlavuza ngokunemba okuphawulekayo. Ihola indlela eya kusasa eliqhakazile nelinempilo!
Wake wacabanga ngamakhono amangalisayo imizimba yethu enawo?
Uma kungenjalo, sekuyisikhathi sokuzuza ulwazi ngalesi sihloko esibalulekile.
Nokho, kuthiwani uma ngingakutshela ukuthi amangqamuzana akho angakwazi ukusebenza njengamaqhawe anamandla, alwe nezifo ezibulalayo njengomdlavuza ngokunemba okungenakuqhathaniswa?
Kungase kuzwakale njengenganekwane yesayensi. Kodwa qagelani? Lo mbutho wamavukelambuso wenza ngokuthula amagagasi, futhi ubizwa ngokuthi I-CAR T Cell Therapy!
Sikumema ukuthi uqonde imininingwane eyinkimbinkimbi ye- Iseli ye-CAR T inqubo isinyathelo ngesinyathelo, kuhlanganise nendlela la maseli atshalwa ngayo, alungiswa kanjani, futhi abuyiselwe emzimbeni wakho ukuze alwe nomdlavuza.
Ngakho-ke, noma ngabe ufisa ukwazi ngalokhu kwelashwa noma isisulu somdlavuza obulalayo, qhubeka ufunda lo mhlahlandlela ukuze uqonde amandla alokhu kwelashwa okuthembisayo.
Ukuqonda I-CAR T Cell Therapy
I-Chimeric Antigen Receptor (CAR) T-cell therapy intuthuko enkulu ekwelashweni komdlavuza eye yavela eminyakeni yamuva nje, iletha ithemba namathuba amasha.
Ukuze uqonde ukwelashwa kwe-CAR T-cell, ake sicabangele amasosha akho omzimba njengebutho elisebenzayo eliqapha umzimba wakho lihlola abahlaseli, okuhlanganisa amangqamuzana omdlavuza.
Abadlali ababalulekile kule ndlela yokuzivikela ama-T-cell—amangqamuzana egazi amhlophe afakwe ama-receptors asebenza njengesistimu yokugada amasosha omzimba. Lawa ma-receptors akhomba izinsongo ezinjengomdlavuza ngokukhomba amaprotheni aziwa ngokuthi ama-antigen ebusweni bamaseli angenayo.
Kodwa-ke, amangqamuzana omdlavuza ayakwazi ukuzifihla ukuze akwazi ukucasha kuma-T-cell akho. I-CAR T cell inqubo yokwelapha izama ukunqoba le nselele ngokuguqula ama-T-cell abe ama-ejenti okulwa nomdlavuza.
Le nqubo ihilela ukuguqula izakhi zofuzo ama-T-cell ukuze aveze i-Chimeric Antigen Receptors (CARs), esebenza njengezikhali ezinamandla, okuvumela ama-T-cell ukuthi abone futhi ahlasele amangqamuzana omdlavuza ngokuphumelelayo.
Ungajabula ukwazi ukuthi cishe amaphesenti angama-70 eziguli ezinomdlavuza asabela kahle kulo Ukwelashwa kwe-CAR T cell therapy eNdiya impela.
Hlola Lokhu : Iqhaza Le-Immunotherapy Ekwelashweni Kwe-Lymphoma - CancerFax
Ingabe Lokhu Kwelashwa Okusha Komdlavuza Kuyathengeka?
Izindaba ezinhle kuzo zonke iziguli ezinomdlavuza laphaya! I-Mumbai-based I-Immunoact new ukwelashwa komdlavuza, I-NexCAR19, ithole imvume.
Okwa- i-leukemia kanye neziguli ze-lymphoma ezingakaphenduli kwezinye izindlela zokwelapha. I izindleko zokwelashwa kwe-CAR T cell eNdiya cishe i-USD 57,000, eshibhile kunezinye izindawo eziningi.
Lokhu kusho India ingase ibe enye yezindawo ezihamba phambili nezithengekayo zalokhu kwelashwa komdlavuza oseqophelweni eliphezulu, okunikeza ithemba kulabo abakudingayo.
Izinhlobo Zomdlavuza Ezelashwa Nge-CAR T Cell Process
Lokhu kwelashwa komdlavuza kusebenza kakhulu ezigulini ezinomdlavuza ezingazange zisabele ku-chemotherapy nezinye izindlela zokwelapha umdlavuza. Lokhu kwelashwa kubonise imiphumela ethembisayo ekwelapheni izinhlobo ezahlukene umdlavuza wegazi. Nalu uhlu lwezinhlelo zokusebenza ezijwayelekile zokwelashwa kwe-t cell:
I-Myeloma eminingi
I-Multiple myeloma wuhlobo lomdlavuza oluqondise ngokuyinhloko amangqamuzana e-plasma, okuyizingxenye ezibalulekile zamasosha omzimba abhekene nokukhiqizwa kwamasosha omzimba.
Kulesi simo, amangqamuzana e-plasma angajwayelekile aphindaphindeka ngokungalawuleki, avale amangqamuzana avamile emnkantsheni wamathambo. I-Immunotherapy kanye ne-stem cell transplantation yiyona ephumelela kakhulu ukwelashwa kwe-myeloma eminingi eNdiya.
I-B-cell Acute Lymphoblastic Leukemia
I-B-cell acute lymphoblastic leukemia (B-ALL) wuhlobo lomdlavuza oluthinta ama-lymphocyte e-B angavuthiwe, iqembu elithile lamangqamuzana amhlophe egazi, phakathi nokukhula kwawo emnkantsheni.
Esikhundleni sokuthi akhule abe amangqamuzana egazi amhlophe anempilo, la mangqamuzana angavuthiwe aba ngokungajwayelekile futhi anda ngokushesha, avale ajwayelekile. Ukwelapha lesi sifo, odokotela bavame ukusebenzisa inhlanganisela yokwelapha ngamakhemikhali kanye nokufakelwa komnkantsha.
I-B-cell Non-Hodgkin Lymphoma
Kunezinhlobo ezingaphansi eziningana ze-B-cell i-non-Hodgkin lymphoma (B-NHL), kufaka phakathi i-B-cell lymphoma enkulu (DLBCL), i-follicular lymphoma ene-DLBCL, kanye ne-B-cell lymphoma yezinga eliphezulu.
Le midlavuza ivela ku-B lymphocyte, uhlobo lwamangqamuzana amhlophe egazi, futhi ihlukaniswa ngokwezimpawu zayo ezihlukile. Umhlinzeki wakho wokunakekelwa kwezempilo angase abhekane nalesi simo nge-chemotherapy, i-stem cell transplants, kanye namasosha omzimba we-monoclonal.
UMantle Cell Lymphoma
I-Mantle cell lymphoma iwuhlobo oluncane lwe-non-Hodgkin lymphoma olusuka kuma-lymphocyte e-B. Lolu hlobo oluthile lwe i-lymphoma ibonakala ngokukhula ngokushesha kwamangqamuzana anomdlavuza, ngokuvamile ahlasela izicubu ezihlukahlukene ze-lymphoid. I-Mantle cell lymphoma ivame ukuphathwa ngenhlanganisela ye-chemotherapy kanye nokufakelwa kwe-stem cell.
Isinyathelo Ngesinyathelo Inqubo Yokwelapha Amaseli E-CAR T
1. Ekuqaleni, umhlinzeki wakho wokunakekelwa kwezempilo ubeka ishubhu elincane (i-catheter) emthanjeni osentanyeni yakho noma ngaphansi kwethambo lakho.
2. Baxhuma i-catheter emshinini wenqubo ebizwa ngokuthi i-leukapheresis. Lo mshini ucubungula igazi lakho, ukhiphe amangqamuzana amhlophe egazi bese ubuyisela amangqamuzana egazi abomvu kanye ne-plasma emzimbeni wakho.
3. Ngemva kwalokho, kwethulwa igciwane elingasebenzi ukuze likunikeze imiyalelo yofuzo emisha kuma-T-cell akho.
4. Ama-T-cell akho aqala ukukhiqiza ama-chimeric antigen receptors (CAR) nama-molecule ahlome ngeziqondiso ezintsha zofuzo.
5. Ama-receptor e-CAR agcina engaphezulu kwama-T-cell akho, kuyilapho ama-molecule ehlala ngaphakathi, enikeza amasignali ukugcina ama-T-cell akho esebenza.
6. Iqoqo elincane lamaseli e-CAR T liyagqugquzelwa ukuthi liphindaphindeke futhi likhule kuze kube anele ukukhomba amangqamuzana omdlavuza ngempumelelo. Lawa maseli aba yiqhwa futhi agcinwe efrijini kuze kube yilapho edingeka.
7. Ngaphambi kokuthola amaseli amasha, uzokwelashwa ngamakhemikhali ukuze uvimbele amasosha akho omzimba ukuba angawenqabi.
8. Ngemva kokwelashwa ngamakhemikhali, uzothola amaseli amasha ngokumnika, kungaba sesibhedlela izinsuku ezimbalwa noma, kwezinye izimo, ngaphandle kokuhlala esibhedlela, ngaphansi kokuqondisa kwethimba lakho lezempilo.
9. Uma isingenile emgudwini wegazi lakho, i-CAR T-cell receptors ibona futhi ibophe ama-antigen (amaprotheni) kumaseli omdlavuza.
10. Ama-CAR T-cell akho abe esephindaphindeka futhi aqale ukubulala amangqamuzana omdlavuza ngokunemba. Amaseli akho e-CAR T ayaqhubeka nokukhula futhi abheke amaseli amasha ane-antigen eqondiwe ukuze aqinisekise ukuvimbela umdlavuza isikhathi eside.
I-CAR T Cell Therapy Side Effects Okufanele Uyazi
I-Cytokine Release Syndrome
Lona umphumela ongaseceleni ovamile lapho amangqamuzana e-CAR T afakiwe ebangela ukukhululwa kwama-cytokines, okuholela ezimpawini ezifana nemfiva, umfutho wegazi ophansi, kanye nobunzima bokuphefumula.
Ubuthi Bezinzwa
Abanye abantu bangase babe nokudideka, ukuquleka, noma ezinye izinkinga zemizwa ngenxa yomthelela wokwelashwa kwe-CAR T-cell ohlelweni lwezinzwa olumaphakathi.
Ukucindezelwa komnkantsha
Ukwelashwa kwe-CAR T-cell kungakhawulela ukukhiqizwa kwamangqamuzana egazi emnkantsheni wethambo, okuholela emazingeni aphansi amangqamuzana abomvu egazi, amangqamuzana egazi amhlophe namaplatelet.
Izifo
Iziguli ezinezivikeli mzimba ezibuthakathaka, ikakhulukazi ngesikhathi sokuqala ngemva kokwelashwa, zisengozini enkulu yokutheleleka.
Imicabango Final
Njengoba siphetha ukuhlola kwethu I-CAR T Cell Process, masihambisane nokuqaphela okunika amandla ukuthi isayensi ivula izindlela ezintsha ekulweni nomdlavuza.
Indlela ye-CAR T cell ingaphezu nje kokwelapha; kuwubufakazi bezinto eziphawulekayo intuthuko eyenziwayo ekwelashweni komdlavuza komuntu siqu.
Ngakho-ke, kubo bonke labo ababhekene nale nselele ngesibindi, yazini ukuthi umhlaba wezokwelapha uyathuthuka, futhi isinyathelo ngasinye esiya phambili siyisinyathelo esibheke ekusasa eliqhakazile, elinempilo. Sikufisela ukululama okusheshayo nekusasa elinempilo!
