Inyuvesi yaseTexas Isikhungo Somdlavuza we-MD Anderson futhi Inkampani ye-Takeda Pharmaceutical Abalinganiselwe bangene ekuqondeni okunemingcele kanye nemvume yocwaningo ukuze bathuthukise futhi bamakethe i-chimeric antigen receptor eqondiswa umbulali wemvelo (CAR NK)- ukwelashwa kwamaseli.
Ngaphansi kokuqonda, u-Takeda uzothola ukufinyelela esigabeni sokwelashwa sika-MD Anderson ukuze adale futhi amakethe ukwelashwa kwe-CAR NK-cell kumaphrojekthi afinyelela kwangu-4, njengoba kuboniswe yisimemezelo esenziwe ngoLwesibili okungukuthi ngomhla ka-4 kuNhlolanja. kanye nokuzibophezela ekuthuthukiseni izindlela zokwelapha zamaseli esizukulwaneni esilandelayo, u-Takeda ungumhlanganyeli ofanelekayo wokusiza ithimba lethu ukuthi lithuthukise izindlela zokwelapha ze-CAR NK-cell ezigulini ezidinga ukwelashwa, "kusho uKaty Rezvani, MD, PhD, uprofesa wokufakelwa kwe-stem cell kanye nokwelashwa kwamaselula. ku-MD Anderson.
Ukwelashwa kunezindlela zokuqhathanisa nokwelashwa kwe-CAR T-cell okuthandwa kakhulu, okubonisa isiqiniseko esibalulekile ezifweni eziningi, ngokuqoqa ama-platelet athile amhlophe eziguli, ahlonyiswe ngama-receptor angaphezulu agxile ukulwa nokukhula okulimazayo kwesifundo, bese kuthi kamuva baphinde bangene egazini lesiguli.
Noma kunjalo, i-chemotherapy ingase ishiye iziguli ezimbalwa zingenawo amaseli e-autologous anele egazini lazo ukuze zelashwe ISITOLO SEZIMOTO ukwelashwa, kuyilapho abanye bengase bangabi nalo ithuba elidingekayo ukuze ilebhu idale ama-T cell anele, njengoba kuboniswa abahlaziyi.
Ukwelashwa kwe-NK-cell yemoto, okudalwe kwa-MD Anderson, kusebenzisa amaseli abulalayo avamile asuka egazini lezintambo. Iqembu lithe livumela ukukhiqizwa kokwelashwa okungadingi ukuthi kwenziwe ngokwezifiso kuso sonke isiguli esisodwa-futhi futhi kuvimbele ukuba nokwenzeka kokujoyina uma kuqhathaniswa nesifo, okuyingozi nge-assortment ye-T-cell.
Iqembu le-MD Anderson lasebenzisa i-retrovirus ukuletha izimfanelo ezintsha kumaseli e-NK: I-CD19 yengezwa ukuze kwandiswe ukucaca kwe-CAR NK ku-B-cell malignancies; i-interleukin 15 (IL15) yengezwa ukuze kukhishwe okwamanje amafoni emzimbeni; kanye "nekhwalithi yokuzibulala" esekelwe ku-CASP9 njengohlobo lwesilinganiso sokuphepha, esingase sicushwe ukuze kucushwe i-apoptosis ngezinciphisi ze-athomu ezincane uma kunekhwalithi enobuthi ngemva kokuhlaselwa.
Lapho bememezela ukuqonda, u-MD Anderson kanye no-Takeda bagcizelela ukuthi ukwelashwa kwe-CAR NK ngaphandle kwe-rack kungalawulwa ezindaweni ezilaliswa ngaphandle.
Kuze kube manje, ukwelashwa kubonise ukuthi kuphephile: Isigaba esiqhubekayo sokuhlolwa kwe-I/2a ezigulini ezine-backslid kanye ne-headstrong B-cell malignancies kubonise ukuthi ukwelashwa kwe-CD19 CAR NK akuzange kuhlotshaniswe nesifo sokukhipha i-cytokine ngokweqile noma i-neurotoxicity saw zokwelapha ezikhona ze-CAR-T.
U-Takeda uthe bahlose ukuqala uphenyo olubalulekile lokwelashwa kwe-CD19 CAR NK-cell ngo-2021.
Ungahle uthande ukufunda: I-CAR-NK Ukwelashwa kwamaseli
U-MD Anderson uthola isitolimende esingaguquki esingachazwanga yimibuthano njengengxenye yohlelo, njengobukhosi obubekwe eceleni kumadili atholakalayo, njengoba kuboniswe esimemezelweni.
URezvani uthe inhloso wukwenza amakhambi afinyelela ezigulini agcine eguqule impilo.
"Umbono wethu uwukuthuthukisa ekwelashweni okukhona ngokuthuthukisa ama-CAR NK ahlomile anganikezwa ngaphandle kweshalofu endaweni yeziguli ezilaliswayo, okwenza iziguli eziningi zelashwe ngempumelelo, ngokushesha, kanye nobuthi obuncane," kusho uRezvani.
