Le ndatshana ihlolisisa izivivinyo zemitholampilo yomdlavuza e-China eminyakeni embalwa edlule, igxile ekutholeni okukhulu nasezindaweni zenqubekelaphambili. Iphinde idingide ngemithi yomdlavuza esanda kugunyazwa e-China, ihlola indlela yokusebenza kwayo, ukusebenza kahle okuvela ezivivinyweni, imiphumela engemihle engaba khona, kanye nokuqagela ekufinyeleleni nasekuthengeni.
Umdlavuza uyimbangela enkulu yokufa kwabantu eChina, njengoba kutholakala abantu abasha abangaphezu kwezigidi ezi-4.5 unyaka ngamunye. Ngokubona ukungathi sína kwalesi simo, izwe lenze intuthuko enkulu ocwaningweni lomdlavuza, laluguqula lwaba yisizinda socwaningo lwemitholampilo olunemiphumela efinyelela kude. Sezadlula izinsuku zezifundo ezinomkhawulo eziqondiswe kwidlanzana lomdlavuza! Namuhla, iShayina inomkhakha obanzi futhi okhula ngokushesha wokuhlolwa komtholampilo, ihlola izinhlobo eziningi zomdlavuza futhi iphenya namasu okwelapha athuthukile. Izivivinyo zemitholampilo ezingama-722 zenziwa ngonyaka ka-2020 kuphela. Inani lezivivinyo zomtholampilo zomdlavuza e-China lenyuke laya ngaphezu kwenkulungwane ekupheleni kuka-2023.
Izivivinyo zomtholampilo zomdlavuza eChina ziholela entuthukweni entsha ezindleleni zokuvimbela, amathuluzi okuxilonga, imithi ehlosiwe, inhlanganisela ye-immunotherapy, kanye I-CAR T cell therapy eChina.
Kodwa kungani kubalulekile ukuqonda lezi zinhlolo zomtholampilo?
Impendulo ilele emandleni abo okwelapha iziguli ezinomdlavuza hhayi eChina kuphela, kodwa emhlabeni wonke.
Le bhulogi ihlose ukuba umhlahlandlela wakho kulo mhlaba oguquguqukayo nothembisayo, ikunikeza imininingwane ngentuthuko yakamuva namandla azo okulolonga ikusasa lokunakekelwa komdlavuza.
Hlala unolwazi : Amaseli E-CAR T Alungisa Kabusha Ikusasa Lokwelashwa Komdlavuza!
Isimo Samanje Sokuhlolwa Komtholampilo Womdlavuza E-China
Nawa amanye amaphuzu abalulekile okuhlolwa komtholampilo okwenziwe eminyakeni embalwa edlule -
I-Immunotherapy Iyakhuphuka
I-PD-1 inhibitors: Izivivinyo ezimbalwa eziphenya nge-PD-1 inhibitors zomdlavuza ohlukahlukene, okuhlanganisa wamaphaphu, isibindi, nesisu, zibonise ukusebenza ngempumelelo okumangazayo kanye namaphrofayili okuphepha. Ngokuphawulekayo, ucwaningo lwe-PD-1 inhibitor entsha yomdlavuza wesisu othuthukile luthole ukuthuthuka okukhulu ekusindeni okumaphakathi okuphelele uma kuqhathaniswa nokwelashwa ngamakhemikhali.
I-CAR-T cell therapy: Izilingo ze I-CAR T cell therapy yomdlavuza eChina, ngokumelene ne-acute lymphoblastic leukemia (ALL) kanye neminye imidlavuza ye-hematological ibonise amazinga okuxolelwa okuphelele, okwandisa ithemba lezixazululo zezokwelapha eziqondene nomuntu. Izinhlangano eziningi ezihlonishwayo zokunakekelwa kwezempilo e-China ziyahlinzeka ukwelashwa umdlavuza mahhala e-China njengengxenye yokuhlolwa komtholampilo kulabo abangakwazi ukukhokhela izindleko zokwelashwa komdlavuza.
Inqubekelaphambili ku-Precision Medicine
Ukwelapha okuhlosiwe: Ukuhlolwa kwezindlela zokwelapha ezihlosiwe okuhloswe ngazo ukuxhaphaza ukuguqulwa kofuzo okuthile kumathumba kubonisa imiphumela ethembisayo. Isibonelo, ucwaningo olusebenzisa i-tyrosine kinase inhibitor eqondene nokuguqulwa kwe-KRAS kumdlavuza wamaphaphu luholele ekuncipheni okukhulu kwesimila kanye nokusinda isikhathi eside ngaphandle kokuqhubeka.
I-Liquid biopsy: Amasu we-biopsy oketshezi angavamisi asuselwe ku-DNA yesimila esijikelezayo (ctDNA) aya ngokuya esetshenziswa ukulandelela impendulo yokwelashwa kanye nokuthola amasignali okuqala okuphinda aqubuke. Ucwaningo lwakuqala oluhlola amandla azo okuthuthukisa ukwelashwa komuntu siqu luyaqhubeka.
Ngokungafani nama-biopsies ezicubu ezihlaselayo ezivamile, ama-biopsies e-liquid ahlonza futhi abonise umdlavuza kusetshenziswa ama-biomarker aqukethwe oketshezini lwe-physiological, njengegazi. I-Liquid biopsies, edinga isampula yegazi kuphela, yenza ukuhlolwa okuphephile nokuphindaphindiwe, okuvumela ukuqapha kwesikhathi sangempela kokuqhubeka kwesifo kanye nokusabela kokwelashwa.
Ukudidiyelwa Kwemithi Yesintu
Ukuhlanganisa imithi yendabuko yamaShayina (i-TCM) nemithi yokwelapha yaseNtshonalanga: Ucwaningo oluningana lubheka imiphumela ye-synergistic yamakhambi e-TCM nezindlela zendabuko zokunciphisa imiphumela emibi yomdlavuza kanye nokuthuthukisa impumelelo yokwelashwa. Izibonelo zifaka phakathi izifundo ezihlanganisa i-TCM ne-chemotherapy yomdlavuza wamaphaphu kanye nokwelashwa ngemisebe ye-nasopharyngeal carcinoma.
Zitholele Ithemba : I-PET CT Scan Ikushintsha Kanjani Izimpilo Zeziguli Zomdlavuza Emhlabeni Wonke?
Ukuphathwa Kwezokwelapha KwaseChina Kugunyaze Umuthi Omusha Womdlavuza Wepheshana Le-biliary Metastatic
Izindaba ezimnandi ezigulini ezinomdlavuza we-metastatic biliary tract (BTC)! I-National Medical Products Administration (NMPA) yase-China igunyaze i-Imfinzi (durvalumab), umuthi we-immunotherapy, ohlanganiswe nokwelashwa ngamakhemikhali okuvamile kokwelashwa komugqa wokuqala.
Lesi yingqopha-mlando enkulu, njengoba inikeza inketho entsha, esebenza kangcono kulezi ziguli, ezivame ukuba nezifo ezimbi.
Kungani Lolu hlobo Lomuthi Lubalulekile Ekunakekelweni Komdlavuza?
Umdlavuza we-biliary tract umdlavuza onamandla onezinketho zokwelashwa ezinomkhawulo. Ukuxilongwa kusenesikhathi akuvamile, futhi amazinga okusinda aphansi.
I-Imfinzi, ihlangene nokwelashwa ngamakhemikhali, yaveza imiphumela emihle. Ezivivinyweni zomtholampilo, iziguli ezithole le nhlanganisela zazinengozi ephansi yokufa ngama-22% kunalezo ezithole ukwelashwa ngamakhemikhali kuphela. Lokhu kwaholela ezikhathini zokusinda ezinde kanye nezinga lempilo elingase libe ngcono.
I-Imfinzi isivele igunyaziwe kwamanye amazwe, futhi lokhu kugunyazwa kwenza ukwelashwa kutholakale ezigulini zase-China, lapho kwenzeka cishe ama-20% ezimo zomhlaba jikelele ze-BTC.
Isebenza Kanjani Imfinzi?
Ingokwesigaba semithi yomdlavuza ebizwa ngokuthi i-immunotherapy, esebenzisa amasosha omzimba ukulwa nomdlavuza. I-Imfinzi iqondise futhi ivimbele i-PD-L1, iphrotheni esetshenziswa amangqamuzana omdlavuza ukugwema amasosha omzimba. Lokhu kuthuthukisa ikhono lamaseli omzimba okubona futhi alwe namaseli wesimila.
Nakuba lezi kuyizindaba ezinhle, ucwaningo olwengeziwe luyadingeka kule ndawo. Imiphumela yesikhathi eside kanye nempumelelo emiphakathini eyahlukene yeziguli idinga ukucutshungulwa.
Noma kunjalo, lokhu kugunyazwa kuletha ithemba elisha leziguli ezinomdlavuza we-biliary futhi kugqamisa amandla e-immunotherapy ekwelashweni komdlavuza.
Gxilisa Ukuqwashisa Kwakho: Ukubhekisisa Izigaba Ezihlukahlukene Ze-Myeloma Eningi
Izivivinyo Zemitholampilo Yomdlavuza E-China Ziholele Ekuthuthukisweni Kwezindlela Zokwelapha Ezintsha
Ukuzibophezela kweShayina ocwaningweni lomdlavuza kuveza imiphumela evelele, izivivinyo zomtholampilo zidlala indima ebalulekile ekuthuthukisweni kwezindlela zokwelapha ezisha zokwelapha umdlavuza.
I-CAR-T Cell Therapy
I-CAR-T cell therapy iyindlela ethembisayo neguqulayo yokwelapha umdlavuza esanda kwenza intuthuko enkulu ezifundweni zomtholampilo e-China. Ukwelashwa kwamaseli e-CAR-T kuhilela ukulungisa ama-T cell esiguli ukuze aveze ama-chimeric antigen receptors (CARs), abona futhi abhubhise amaseli wesimila.
Izivivinyo eziningi e-China kule minyaka embalwa edlule zenze izinhlelo zokukhiqiza nokulethwa kwe-CAR-T ziphelele, okuholele emazingeni okusabela ahlaba umxhwele kwezinye izinhlobo zomdlavuza wegazi ezifana ne-lymphoma ne-leukemia lapho ezinye izindlela zokwelapha zehlulekile.
Omunye umkhakha wocwaningo oqhubekayo ukuthuthukiswa kwe Ukwelashwa kwe-CAR-T iqondise ama-antigen amasha axhunywe kuhlu olubanzi lwezicubu ze-hematological neziqinile.
I-PD-1 Inhibitors
I-PD-1 inhibitors yenze intuthuko enkulu ku-cancer immunotherapy. Eminyakeni yamuva nje, izivivinyo eziningi zemitholampilo e-China ziphenye amasosha omzimba e-PD-1 inhibitor ngokumelene nezinhlobo ezihlukahlukene zomdlavuza.
Le mithi isebenza njengezivimbamgwaqo ezincane, ivimbela amangqamuzana omdlavuza ekuthumeleni “izimpawu zokumisa” kuma-immune T cell. Ngalezi zithiyo endaweni, ama-T cell ayakhululwa, abone futhi ahlasele umdlavuza ngamandla anda.
Ngokuphawulekayo, ama-PD-1 inhibitors abonise isithembiso esihle ezivivinyweni zomdlavuza wamaphaphu okungewona omncane, okwandisa amazinga okuphendula, ukusinda okungenanqubekela phambili, nokusinda kukonke uma kuqhathaniswa nokwelashwa ngamakhemikhali.
Izindlela zokwelapha ezihlosiwe
Ukwelashwa komdlavuza okuhlosiwe okuvimbela ngokuqondile abashayeli bezakhi zofuzo ezithile zokukhula nokuqhubeka kwesimila sekuvele njengensika eyinhloko ye-oncology enembile. Intuthuko eshesha kakhulu ekwelashweni okuhlosiwe yenzekile kumdlavuza wamaphaphu, ngovivinyo lwakamuva lwase-China lwama-ejenti afana ne-anlotinib, kanye ne-icotinib ethola amazinga okuphendula athembisayo kanye nentuthuko yokusinda, okuholela ekugunyazweni okumbalwa kokulawula. Izivivinyo ziphinde zihlole izindlela zokwelapha ezihlosiwe ezifaniswe nama-biomarker esibindini, esiswini, kanye nomdlavuza we-colorectal.
Imithi Yokwelapha Ehlanganisiwe
Imithi yokwelapha eyinhlanganisela, esebenzisa imishanguzo emibili noma ngaphezulu enezinqubo ezihlukene, ithola ukuduma emzamweni wokulwa nomdlavuza waseChina. Le ndlela ihlose ukubhekana nemikhawulo yokwelashwa kwe-ejenti eyodwa ngokukhulisa ukusebenza kahle, ukwehlisa ukumelana, nokunciphisa imiphumela emibi.
Inhlanganisela yokwelashwa okuhlosiwe nge-immunotherapy, i-gene therapy, noma ezinye izindlela zokwelapha icutshungulwa kakhulu ukuze kuzuzwe izinzuzo ze-synergistic ngokumelene nezinhlobo ezahlukene zomdlavuza.
Lezi zinhlanganisela zibonisa ukusebenzisana okukhethekile, nezivivinyo zakamuva ezibonisa amazinga okuphendula angafika ku-90% ngaphandle kobuthi obengeziwe uma kuqhathaniswa nemithi eyodwa kuphela.
I-Tumor-Infiltrating Lymphocyte Therapy
Ukwelashwa kwe-Tumor Infiltrating Lymphocytes (TIL). iyindlela enamandla futhi yomuntu siqu yokwelapha amasosha omzimba yamathumba athile aqinile. Yenza amasosha omzimba esiguli asebenze ngokuqoqa futhi aphindaphinde ama-T cell alwa nesimila akhona ngokwemvelo ngaphakathi kwesimila. Lawa “masosha aqeqeshiwe,” aziwa ngokuthi ama-TIL, abe esebuyiselwa esigulini, elungele ukuqaphela nokuqeda amangqamuzana omdlavuza.
Ngokungafani namaseli e-CAR T, athuthukiswe ukukhomba izimpawu ezithile kumaseli omdlavuza, Ama-TIL banenzuzo enkulu: babona izinhlobonhlobo zezinhloso esimila esigulini. Lokhu kungenxa yokuthi sebevele bangenile ku-microenvironment yesimila, befunda mathupha “izigxivizo zeminwe” zesitha.
Le ndlela enezinhlangothi eziningi yenza kube nzima kakhulu ngesimila ukubalekela ukwelashwa ngokufihla okuhlosiwe okukodwa, okunikeza inzuzo ebalulekile yokwelapha.
Izilingo Zomtholampilo Zomdlavuza E-China Zithola Ukunakwa Kwembulunga yonke
Ukuzibophezela kweShayina ocwaningweni lomdlavuza kuveza imiphumela emihle kakhulu, izivivinyo zomtholampilo zidlala indima ebalulekile ekuthuthukisweni kwezindlela zokwelapha ezisha. Lokhu kwanda komsebenzi akumeli nje inqubekelaphambili enkulu eChina kodwa futhi kunikeza ithemba ngempi yomhlaba wonke yokulwa nomdlavuza.
Inombolo Ekhulayo Nokuhlukahluka
Inani lezivivinyo zemitholampilo e-China liyakhula, lihlanganisa izinhlobo eziningi zomdlavuza, kusukela ezinhlotsheni ezivamile ezinjengomdlavuza wamaphaphu nowesisu kuye kwezingajwayelekile. Lokhu kwehlukahlukana kwenza abacwaningi bakwazi ukuphenya ngezindlela ezahlukene zokwelapha umdlavuza.
Izindlela Zokwelapha Ezithuthukile
Abacwaningi bahlola ama-immunotherapies amasha afana ne-CAR-T cell therapy kanye ne-PD-1 inhibitors, kanye nokwelapha ngezakhi zofuzo nemithi eqondiwe ngokusekelwe ekuguquguqukeni kofuzo okuthile. Lezi zinesithembiso sokwelashwa komuntu siqu kanye nezinhlelo zokwelashwa ezisebenza kangcono.
I-Liquid Biopsy Revolution
I-China ifunda ngenkuthalo i-liquid biopsy, indlela engahlaseli igazi yokuhlaziya i-tumor DNA nezinye izinkomba. Lokhu kuvula iminyango yokutholwa kusenesikhathi kanye nokuqapha ngesikhathi sangempela izimpendulo zokwelashwa.
Ukusebenzisana Nokusungula
I-China iya ngokuya isebenzisana nabacwaningi bamazwe ngamazwe nezinhlangano ukuze kube lula ukushintshana ngolwazi nokusheshisa ukuthuthukiswa kwezindlela zokwelapha ezintsha. Lokhu kukhuthaza indlela yomhlaba wonke yocwaningo lomdlavuza, oluzuzisa iziguli emhlabeni jikelele.
Imicabango Final
Njengoba siphetha lesi sihloko mayelana nokuhlolwa komdlavuza e-China, kubalulekile ukuqaphela ukuthi lesi yisiqalo nje. Lezi zinhlolo eziqhubekayo, ezisukela ku-revolutionary immunotherapies kuya ezindleleni zokwelapha eziqondene nomuntu, zinemithelela efinyelela kude emingceleni yezwe. Isinyathelo ngasinye esiya phambili eChina sinomthelela emhlabeni jikelele, sinikeza ithemba kwabagulayo futhi sithuthukise impi yokulwa nalesi sifo esiyinkimbinkimbi.
