Ukukhuluphala akugcini nje ngokuphikisana nobuhle babantu, kodwa futhi kubangela izifo eziningi ezingapheli. Olunye ucwaningo luye lwabonisa ukuthi inkomba yesisindo somzimba (BMI) ihlobene nengozi yomdlavuza ezingxenyeni ezithile (njengesistimu yokugaya), kodwa asikho isiphetho esihlangene ngobuhlobo nomdlavuza kwezinye izingxenye. Ukubuyekezwa kwesambulela esishicilelwe ku-Annals of Oncology ekupheleni kuka-2017, sihlaziya ngokuphelele ubudlelwano phakathi kwe-26 BMI nobungozi bomdlavuza.ta, futhi silwele ukuletha iziphetho ezigunyaza kakhulu kubafundi.
Ucwaningo lwaluhlanganisa kuphela ukuhlolwa kwempendulo yobuningi phakathi kwe-BMI kanye nengozi yokuhlaziywa komdlavuza, ingqikithi yezihloko ze-26. Sebenzisa ukubuyekezwa kwesambulela (okungukuthi ukuhlaziywa kwe-meta eminingi ukuze ubuyekeze), uphinde uhlaziye ubudlelwano phakathi kwe-BMI nezinhlobo ezingama-20 zomdlavuza.
Imiphumela yocwaningo ibonise ukuthi izinhlobo ezinhlanu zomdlavuza (i-leukemia, i-myeloma eminingi, umdlavuza we-pancreatic, umdlavuza we-endometrial, umdlavuza we-rectal, kanye ne-renal cell carcinoma) yayinamandla aphezulu okuxhumanisa ne-BMI; izinhlobo ezintathu zomdlavuza (i-melanoma eyingozi, i-non-Hodgkin) I-Lymphoma ne-esophageal adenocarcinoma) kanye ne-BMI ifinyelela ezingeni elilinganiselwe lamandla; ngenxa yezimila zobuchopho nesimiso sezinzwa esimaphakathi, umdlavuza webele, umdlavuza wekoloni, umdlavuza wenyongo, umdlavuza wamaphaphu, umdlavuza wesibindi, umdlavuza wesibeletho nomdlavuza wegilo, kunezinga eliphansi le-BMI Degree of association; akukho ukuhlobana phakathi kokuvela komdlavuza wesinye, umdlavuza wesisu kanye nomdlavuza wendlala yesinye kanye ne-BMI.
Ubudlelwano phakathi kokwenyuka kwe-BMI kanye nokuvela komdlavuza buyahluka kakhulu phakathi kwezinhlobo zomdlavuza. Ngokusho kokuhlaziywa, ukuvela kwe-leukemia, i-myeloma eminingi, umdlavuza we-pancreatic, umdlavuza we-endometrial, umdlavuza we-rectal kanye ne-renal cell carcinoma kuhlotshaniswa kakhulu nokwanda kwe-BMI.
Inkomba yesisindo somzimba kanye nomdlavuza othize we-20: ukuhlaziywa kabusha kokuhlaziywa kwe-dose-response meta-analyses yezifundo zokubheka. U-Ann Oncol. 2017 Dec 28. doi: 10.1093 / annonc / mdx819.
