I-bone marrow fibrosis yisifo esingajwayelekile esingalapheki samangqamuzana omnkantsha we-hematopoietic. Bayazuza ezidakamizweni ze-JAK2 inhibitor: ukukhululeka kwezimpawu, ukusinda isikhathi eside, nezinga lempilo elithuthukisiwe. Kodwa-ke, eminyakeni emibili noma emithathu ngemuva kokuqala ukwelashwa, ezinye iziguli ziba nolaka lwe-B-cell lymphoma. Ngokusebenzisana eduze nabacwaningi baseVienna, eMedUni naseVetmeduni, ama-JAK2 inhibitors avuse i-lymphoma “elele” kanye nomdlavuza emnkantsheni okokuqala ngqa.
Using bone marrow biopsy at the beginning of the disease, 16% of patients with myelofibrosis were found to have dormant aggressive lymphoma. In about 6% of these patients, when stimulated with JAK2 inhibitors, it bursts. According to hematologists, if sensitive molecular biology techniques are used to actively search for latent lymphoma, it is possible to detect dormant lymphoma. This is the best predictive tool that allows us to screen out 16% of patients identified as high-risk patients before treatment with JAK2 inhibitors.
Kwafakazelwa ngemodeli yegundane ukuthi amagundane ayethunyelwe ukufakelwa umnkantsha wabuye wakhula ne-lymphoma. Ukubambisana kwamazwe amaningi kuyisibonelo esihle sokuthi ucwaningo seluvuleke kanjani nokubaluleka kokushintshaniswa kwedatha kwezokwelapha. Isinyathelo esilandelayo: ukuqoqwa kwamacala aphesheya kanye nedatha ehlobene nayo isiqale ukuqhubeka nokwenza ngcono ukuphepha kwezidakamizwa, futhi abacwaningi basebenzisana kakhulu nezinkampani ezithaka imithi ezikhiqiza le mithi ejwayelekile. Sungula ibhuloho elisheshayo, elisebenza kahle nelibhidlika phakathi kwamamodeli wegundane nokutholakele kwemitholampilo, kuhlanganisa ngokuphelele ucwaningo oluyisisekelo, umsebenzi wangaphambi kokwenza nokwelashwa ukuze kuzuze iziguli ezinomdlavuza.
