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Isidakamizwa esibhekiswe ku-AstraZeneca i-Acalabrutinib inendlela entsha yokwelapha i-leukemia engapheli ye-lymphocytic

Yabelana ngalokhu okuthunyelwe

I-Acalabrutinib iyi-inhibitor yesizukulwane sesibili i-tyrosine kinase (BTK) inhibitor, umuthi omusha ongathuthukisa ukusinda kwe-lymphocytic leukemia (CLL) ne-mantle cell lymphoma (MCL).

Abaphenyi bakholelwa ukuthi ama-BTK inhibitors ahlanganiswe nezidakamizwa eziguquliwe ze-CD20 (ezifana ne-Obinutuzumab) angathuthukisa ijubane nokujula kokwelashwa kwe-Acalabrutinib ngokuphendula kwamanye amangqamuzana omdlavuza azwela.

Esivivinyweni somtholampilo sesiGaba 1 b / II, abacwaningi bahlole umphumela wokwelashwa okuhlanganisiwe kwe-Acalabrutinib ne-Obinutuzumab e-Ohio State University Comprehensive Cancer Center-James Cancer Hospital-Richard Research Center (OSUCCC-James), kubizwa abangu-45 baphinde babuyela emuva / baphikisa noma iziguli ze-CLL ezingakaze zithole ukwelashwa.

Sekukonke, ukwelashwa okuhlanganisiwe kwe-Acalabrutinib ne-Obinutuzumab kubekezeleleke kahle, futhi nezinga lokuphendula liye lathuthuka ngokuhamba kwesikhathi.

Phakathi kweziguli ezazingakatholi ukwelashwa, izinga lokuphendula lilonke lalingama-95%. Isikhathi sokulandelela esiphakathi kwaba yizinyanga eziyi-17.8. Izinga lokusinda eliphelele (i-OS) leziguli ezine-CLL ebuyile / ephikisayo laliyi-92%, nesikhathi sokulandelela esiphakathi kwezinyanga ezingama-21.

OSUCCC-James. UProfesa ohlangene kanye nomlobi wokuqala uJennifer Woyach uthe yize kunenqubekela phambili eyenziwe ekwelapheni i-CLL eminyakeni yamuva, isidingo sokwengeza ezinye izindlela zokwelashwa sisaphuthuma.

Ukusebenza kahle okuphelele kocwaningo lwe-Acalabrutinib kugcizelela ukuthi lolu cwaningo lomtholampilo lungaba nomthelela ongaba khona ekuphathweni kwe-CLL.

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