Ososayensi base-Michigan State University baklama inhlayiyana efana negciwane ebizwa ngokuthi i-Qβ, ezokhiqiza ukusabela kwamasosha omzimba alwa nomdlavuza emzimbeni futhi ingase isetshenziswe njengomuthi omusha wokugomela ukwelapha umdlavuza. Iphrojekthi ye-US $ 2.4 million exhaswe yiNational Cancer Institute izokweseka ukwakhiwa kwemithi yokugoma ukuvikela izilwane kumangqamuzana omdlavuza angelapheki njengamanje, futhi ingaba umuthi wokugomela umdlavuza ozenzakalelayo kubantu.
Ithimba lizohlanganisa izinhlayiya ze-Qβ nama-antigen ahlobene ne-tumor-associated carbohydrate (TACAs), futhi likholelwa ukuthi la ma-antigen azokhiqiza ukuzivikela okuphelele kwamangqamuzana e-tumor, anciphise ukukhula kwesimila futhi avimbele ukukhula kwesimila. Ngaphezu kwalokho, abacwaningi bazosebenzisa ukwakheka kwekristalu ye-Qβ ukwenza izinguquko ezinciphisa amasosha omzimba anobuthi futhi zikhuthaze amaseli afunekayo, angaphinde abulale amangqamuzana omdlavuza. Lolu ukuhlola kokuqala okunjalo kusetshenziswa imodeli yomgomo we-TACA.
This vaccine will be used first to treat canine cancer and will focus on osteosarcoma, which is a refractory dog and human bone isisu.
Vaccines can reduce tumor growth and protect patients from tumor progression and further progress. If we can further understand the relationship between the structural characteristics of Qβ-TACA and anti-tumor immunity, it can have a great effect on the design of imithi yokugoma umdlavuza. This research also strengthens the important role of veterinary medicine in cancer research.
U-Yuzbasiyan-Gurkan uthe: “Umdlavuza ozenzakalelayo ezinjeni nasemakati unikeza ukuhlolwa kwangempela kwemithi yokugomela umdlavuza. Lesi isibonelo esisodwa sezindlela eziningi ucwaningo lwezokwelapha lwezilwane nolwesintu olungasizana ngazo.”
