According to the latest clinical data, a single pre-genome test is more effective for Lynch syndrome in patients with colorectal cancer (CRC) than traditional multiple sequential testing methods. The researchers say that providing such advanced genetic testing at the time of diagnosis can help guide and speed up treatment decisions for many CRC patients, and at the same time confirm the diagnosis of patients who may have Lynch syndrome (prone to cancer). When a mutation occurs in one of the DNA repair genes of a person, a carcinogenic situation occurs. People with Lynch syndrome are more likely to suffer from CRC, umdlavuza wesibeletho, ovarian cancer, stomach cancer, or other cancers than the general population.
For this study, the researchers wanted to know whether a single test to screen multiple mutations for early-stage isisu sequencing can replace the multiple detection methods currently used to determine whether patients have Lynch syndrome. To this end, the researchers analyzed tumor samples from 419 CRC patients. All study participants analyzed tumor samples using the traditional multiple test genetic test method and a single pre-genome tumor sequencing test. Among them, a single tumor sample analyzed multiple mutation.
Abacwaningi baqhathanise imiphumela yezindlela ezimbili zokuhlola futhi bathola ukuthi indlela yangaphambili yokulandelanisa isimila izwela kakhulu kunemodeli yakudala yokuthola okuningi futhi ingathola ngokuqondile i-Lynch syndrome. Ukulandelana kwesimila sangaphambi kwesiteji kwenyuse izinga lokutholwa kwe-Lynch syndrome ngo-10%, futhi kunikeze iziguli ulwazi olubalulekile mayelana nezinketho zokwelashwa.
Izindlela zokuhlola ezedlule zizobonisa kuphela ukusola kwe-Lynch syndrome, kodwa ngaphandle kokuhlolwa okwengeziwe okwengeziwe, ukuxilongwa akukwazi ukuqinisekiswa, okuzonciphisa inqubo yokuxilongwa nokwandisa izindleko. Le ndlela entsha ikhomba ukuguquguquka okuqondile ekuzalweni kwesiguli, futhi idinga ukuhlolwa okukodwa kuphela, kusetshenziswa ukuhlolwa kwegazi, okushibhile kunekhithi yokuhlola yezakhi zofuzo eziningi. Izindlela zangaphambilini ngezinye izikhathi zazidinga ukuthi iziguli zenze izivivinyo ezinhlanu ezihlukene ngaphambi kokwazi ukuthi zine-Lynch syndrome.
Le ndlela entsha inganciphisa kakhulu ukusebenza kahle kwezindleko, ingakwazi ukunquma ngokunembile imiphumela yokuhlolwa, futhi ingavimbela iziguli eziningi ezisengozini enkulu ukuba zithuthukele ekubeni nomdlavuza.
