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Indlela entsha yokwelapha i-sarcoma engavamile

Yabelana ngalokhu okuthunyelwe

Ososayensi baseTrinity College Dublin (TCD) benze indlela entsha yokwelapha engasiza ekwelapheni i-sarcoma yezicubu ezithambile ezingavamile ezithinta abantu abasha. I-Synovial sarcoma umdlavuza onzima ukuwelapha ngenxa yokuguquka kofuzo. Ivame ukutholakala emilenzeni noma ezingalweni, futhi ingase ivele noma yikuphi emzimbeni.

Ezigulini ezinobukhulu besimila obungu-5-10 cm, izinga lokusinda ngemuva kweminyaka eyishumi lingaphansi kwengxenye eyodwa kwezintathu. Ithimba le-TCD lisebenzise ubuchwepheshe bokuhlola izakhi zofuzo lweCRISPR ukukhomba izinhloso ezingaba khona zokwelapha ku-biology yomdlavuza. Bathola iprotheni ebizwa nge-BRD9, engaqinisekisa ukusinda kwamaseli we-synovial sarcoma ngokusebenza neprotein ye-SS18-SSX edala ukuthuthukiswa kwezifo.

Ososayensi babe sebesungula umuthi ohlose futhi wehlise iprotheni ye-BRD9. Ekuhlolweni besebenzisa amagundane, bathole ukuthi izidakamizwa abazenzile zingalulaza iphrotheni ye-BRD9 futhi ziyisuse kumaseli womdlavuza, angavikela ngempumelelo ukukhula kwesimila. Umbhali ophambili walolu cwaningo, uDkt Gerard Brien, uthe, “Kuzokwenza amaseli aqede amaprotheni ancike kuwo, abangele ukuthi afe.” Ithimba laphinde lathola ukuthi umuthi awuthinti izinqubo zeselula zamaseli ajwayelekile, okudala imiphumela emibi embalwa (uma kunemiphumela engemihle). Uhlelo olulandelayo lwabacwaningi 'luzoba ukuhlola lo muthi omusha ezivivinyweni zomtholampilo zeziguli, futhi ososayensi bathemba ukuthi le mithi izongena emtholampilo maduze nje. Ucwaningo lushicilelwe ephephabhukwini lomhlaba wonke i- “eLIFE”.

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