Ithimba labacwaningi e-Cancer Research Institute (CSI) ye-National University of Singapore lenze umuthi we-peptide obizwa ngokuthi i-FFW ongavimbela ukuthuthukiswa kwe-hepatocellular carcinoma (HCC) noma i-primary. umdlavuza wesibindi . Lokhu kutholwa okuyingqophamlando kuvula umnyango wokwelashwa okuphumelelayo kakhudlwana komdlavuza wesibindi kanye nemiphumela engemihle encishisiwe.
SALL4 is a protein associated with tumor growth and has been used as a prognostic marker and drug target for HCC, lung cancer and leukemia. It is usually present in a growing fetus, but is inactive in adult tissues. In some cancers, such as HCC, SALL4 is reactivated, leading to isisu ukukhula.
Ama-molecule wezidakamizwa asebenza kuma-protein, afana ne-SALL4-NuRD, imvamisa adinga ukuthi iphrotheni elihlosiwe libe "nephakethe" elincane esakhiweni salo esingu-3-D, lapho ama-molecule wezidakamizwa angakhona futhi asebenze khona. Ocwaningweni lokuqala, kutholakale ukuthi iphrotheni le-SALL4 lixhumana nenye iprotheni i-NuRD, lenza ubudlelwano obubalulekile ekuthuthukiseni umdlavuza ofana ne-HCC. I-SALL4 edizayinwe yileli thimba locwaningo ayizange ibheke 'amaphakethe', kepha yakha ama-biomolecule avimba ukuxhumana phakathi kwe-SALL4 ne-NuRD. Ucwaningo luthole ukuthi ukuvimba lokhu kuhlangana kungadala ukufa kwesimila futhi kunciphise ukunyakaza kweseli le-tumor.
FFW can effectively block protein-protein interactions, and does not require “pockets” to take effect. The research team also found that when combined with sorafenib, FFW can reduce the growth of sorafenib-resistant HCC. Although most izindlela zokwelashwa eziqondisiwe are small-molecule drugs, well-designed peptide drugs (such as FFW) tend to have higher selectivity than large-molecule surfaces and are less toxic than small molecules.
Umcwaningi waseSingapore uDkt.Liu Bee Hui uthe: Ngokuya ngolwazi esiluthole esakhiweni nasekukhulisweni kofuzo lomhlaba jikelele, siyaqhubeka nokutadisha le peptide namanye ama-peptide anezinhlaka ezifanayo ukuze ekugcineni sizenze zibe yimithi ebanga imitholampilo futhi silethe iziguli zizuze.
