Izinga lokusinda komdlavuza we-pancreatic liphansi kakhulu. Eminyakeni engama-40 edlule, izinga lokusinda alikashintshi kakhulu. Ukuthola ukwelashwa okusebenzayo kuyinselelo ephuthumayo kubaphenyi. Sekuyiminyaka eminingi, i-tamoxifen isetshenziselwe ukwelapha umdlavuza webele ngoba ivimbela i-estrogen ukukhuthaza ukukhula kwesimila sebele. Muva nje, ucwaningo lukhombisile ukuthi i-tamoxifen ingasetshenziswa ukwelapha umdlavuza we-pancreatic. Ithimba labacwaningi lifakazele ukuthi i-tamoxifen ingasiza ekushintsheni indawo ebonakalayo yokukhula kwesimila segundane, ilawule ukukhula kwezicubu ezibomvu, ukuvuvukala nokuphendula komzimba. Imiphumela yocwaningo ishicilelwe ku- "EMBO Report".
Umdlavuza we-pancreatic, njengamathumba amaningi aqinile, uzungezwe inani elikhulu lezicubu ezixhumeneyo. Izicubu eziqinile ezinjengesibazi zifana nezikafula ezizungeze izimila. Bavimba ukulethwa kwezidakamizwa ngokuvimbela izidakamizwa ze-chemotherapy ukuthi zifinyelele esimila. Ziphinde zilawule ukukhula nokusabalala kwamathumba. Ukwakheka kwezicubu ezixhuma kumathumba e-pancreatic kuqhutshwa amaseli we-pancreatic stellate (PSCs), aqiniswa ukusetshenziswa kwamandla omzimba nokulungiswa kwesakhiwo sezicubu.
Lapho abacwaningi behlola imodeli yesimila segundane le-pancreatic, bathola ukusebenzisana phakathi kwamaseli azungeze isimila se-pancreatic, futhi bafunda nokuthi i-tamoxifen iyishintshe kanjani indawo ezungezile ezungeze isimila se-pancreatic. I-Tamoxifen inamandla okuvimbela izicubu ezixhumene ezizungeze izimila ze-PSC sclerosis futhi ivimbele indawo ezungezile ekubeni lukhuni. I-Tamoxifen ilawula ukuphendula kwamasosha omzimba futhi ingavimbela ukuhlasela nokusabalala kwamangqamuzana omdlavuza. Ngaphezu kwalokho, amangqamuzana akwi-pancreatic tumor athola umoya-mpilo omncane kakhulu, odala indlela yokuzivikela: lapho izinga komoyampilo lehla, ingqamuzana likhipha i-molecule ebizwa ngokuthi i-hypoxia inducible factor (HIF), esiza amangqamuzana omdlavuza Asinde ngaphansi kwezimo. Kodwa i-tamoxifen ingavimbela ukukhiqizwa kwe-HIF, okwenza amangqamuzana omdlavuza abe lula emazingeni aphansi e-oxygen futhi angase afe. Kodwa lo msebenzi njengamanje wenziwa kumamodeli wamaseli namagundane, ngakho ucwaningo olwengeziwe luyadingeka ngaphambi kokuthi lusetshenziswe ezigulini ezingabantu.
