Avgust 2023: Ftorpirimidin, oksaliplatin va irinotekan asosidagi kimyoterapiya bilan davolash qilingan metastatik kolorektal saraton (mCRC) uchun VEGFga qarshi biologik terapiya, agar RAS yovvoyi turi bo'lsa, anti-EGFR terapiyasi bilan oziq-ovqat va farmatsevtika idorasi tasdiqlagan. trifluridin va tipirasil (LONSURF, Taiho Oncology, Inc.). LONSURF, bitta vositali dori, 2015 yil sentyabr oyida ushbu foydalanish uchun FDA ruxsatini olgan.
SUNLIGHT (NCT04737187) da LONSURF va bevacizumabni yagona agentli LONSURF bilan solishtirgan, randomizatsiyalangan, ochiq yorliqli, ko'p markazli, xalqaro sinovda metastatik yo'g'on ichak saratoni bilan og'rigan 492 bemorda ilgari ikki marta kimyoterapiya rejimini olgan va kasallikning rivojlanishini ko'rsatgan. oxirgi rejimga nisbatan murosasizlik, xavfsizlik va samaradorlik baholandi.
Overall survival (OS) and progression-free survival (PFS) were the key effectiveness outcome metrics. Patients assigned to the LONSURF plus bevasizumab arm of the trial showed a statistically significant OS improvement when compared to patients assigned to the LONSURF arm (Hazard ratio 0.61; 95% CI: 0.49, 0.77; 1-sided p0.001). The median OS for the LONSURF plus bevacizumab arm was 10.8 months (95% CI: 9.4, 11.8) and for the LONSURF arm was 7.5 months (95% CI: 6.3, 8.6). In the LONSURF plus bevacizumab arm, the median PFS was 5.6 months (95% CI: 4.5, 5.9), while in the LONSURF arm, it was 2.4 months (95% CI: 2.1, 3.2) (Hazard ratio: 0.44; 95% CI: 0.36, 0.54; 1-sided p0.001).
Neytropeniya, anemiya, trombotsitopeniya, charchoq, ko'ngil aynishi, ASTning ko'payishi, ALT ortishi, gidroksidi fosfatazaning ko'payishi, natriy miqdorining pasayishi, diareya, oshqozon bezovtaligi va ishtahaning pasayishi LONSURF bevacizumab bilan eng ko'p uchraydigan nojo'ya hodisalar yoki laboratoriya anormalliklaridir (20%).
Har bir 1 kunlik tsiklning 5-8-kunlari va 12-28-kunlarida LONSURFning tavsiya etilgan dozasi kuniga ikki marta ovqat bilan birga og'iz orqali qabul qilingan 35 mg/m2 ni tashkil qiladi. Bevacizumab dozasi haqida batafsil ma'lumot olish uchun retsept bo'yicha ma'lumotga murojaat qiling.
LONSURF uchun to'liq retsept ma'lumotlarini ko'ring.
