The latest research result, the immune score test, can now more accurately define the disease progression of colon cancer patients. According to an international study of more than 2,500 patients, immune scores have been shown to be effective in predicting which patients have a high risk of tumor recurrence and can benefit from intensive treatment after surgery.
Yo'g'on ichak saratonining og'irligini asosan uning yo'g'on ichakda tarqalishi va metastaziga qarab baholash kerak. Saratonning tajovuzkorligi va davolanishdan keyin takrorlanish xavfini baholash davolashni yaxshilaydi. O'nlab yillar davomida bemorlarning immuniteti saraton kasalligiga foydali ta'sir ko'rsatadi, deb ishonilgan. Oxirgi tadqiqotlar shuni ko'rsatadiki, saraton o'smalarining immunitet hujayralari tomonidan bosib olinishi kolorektal saraton rivojlanish yo'nalishining yaxshi ko'rsatkichi bo'lishi mumkin, bu kasallikning rivojlanishi haqida eng ko'p ma'lumotga ega bo'lgan immunitet hujayralari populyatsiyasini aniqlash uchun potentsial prognostik vositaga aylanadi.
Ushbu immunologik testni yaratish klinik amaliyotga mos keladi. U o'smadagi ikkita immunitet hujayralarining zichligini va ularning invaziya chegarasini aniqlash orqali ishlaydi: umumiy T hujayralari (CD3 +) va killer T hujayralari (sitotoksik CD8 +). Ushbu tadqiqot juda katta miqdordagi yo'g'on ichak saratoni bilan kasallangan bemorlarning, shu jumladan turli xil markazlardan kelgan 2681 bemorning prognostik qiymatini baholadi. Qaytalanish xavfi (operatsiyadan 5 yil o'tgach) va hayot darajasini baholash bo'yicha bemorlar prognostik ko'rsatkichlarni taxmin qilish uchun uchta guruhga (yuqori, o'rta va past) immunitet ko'rsatkichlariga bo'lingan. Natijalar shuni ko'rsatadiki, yuqori immunitet ko'rsatkichlari bo'lgan bemorlarda takrorlanish xavfi va yashash muddati uzoqroq.
Of the 700 patients, only 8% of patients with high scores relapsed after 5 years. However, the relapse rate of patients with middle and low scores increased significantly, reaching 19% and 32%, respectively. These findings indicate that the immune score provides an accurate and reliable assessment of the risk of colon cancer recurrence. Use the risk of recurrence to improve individual patient treatment strategies, especially changes in chemotherapy regimens. In view of the highly positive results of colon cancer, immunoscore tests for other cancers are under way, which will revolutionize the treatment of cancer patients.
