Surunkali yallig'lanish kolorektal saraton uchun predispozitsiya qiluvchi omil bo'lib, Qo'shma Shtatlarda saraton bilan bog'liq o'limning uchinchi sababidir. Doktor Anna Means va uning hamkasblari o'tgan oy "Cell and Molecular Gastroenterology and Gepatology" jurnalida yo'g'on ichakning yallig'lanishga asoslangan karsinogenezini SMAD4 deb nomlangan muhim signalizatsiya oqsilining yo'qolishi bilan bog'lashdi. SMAD4 yo'g'on ichak epiteliysida infektsiyaga qarshi immun va yallig'lanish reaktsiyasini tartibga soluvchi o'sish omili b (TGF-b) signalizatsiya yo'lining bir qismidir.
In vivo jonli ravishda o'stirilgan sichqonchaning yo'g'on ichak epitelial hujayralarida SMAD4 genining o'ziga xos o'chirilishi yallig'lanish vositachilarining ifodasini oshirdi. Yallig'lanishi bo'lgan kattalar sichqonlarida SMAD4 etishmasligi o'smalar va inson kolitlari bilan bog'liq saraton o'rtasidagi hayratlanarli o'xshashlikka olib keladi.
Loss of SMAD4 was also observed in 48% of human colitis-related cancers, compared with 19% of scattered kolorektal saraton. “This loss may be an important factor from premalignant lesions to aggressive malignant tumors,” the researchers concluded. Therefore, friends with chronic inflammation must eliminate inflammation in time, and do not regret it until the inflammation develops into cancer.
