Garvard tibbiyot maktabi va Massachusets umumiy kasalxonasining Mingyang Song metastatik bo'lmagan yo'g'on ichak saratoni tashxisidan so'ng, ko'proq tolani iste'mol qilish kolorektal saratonning o'ziga xos o'limini va umumiy o'limini kamaytiradi. Tashxis qo'yilganidan keyin tolaning ko'payishi kolorektal saraton kasalligi bilan og'rigan bemorlarga foyda keltirishi mumkin. (JAMA Oncol. Onlayn versiyasi 2 yil 2017-noyabr).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal saraton kasalligidan omon qolganlar.
Tolalarni iste'mol qilish va o'lim o'rtasidagi munosabatlarni baholash uchun tadqiqotda ikkita istiqbolli kogortadan kolorektal saraton kasalligining I-III bosqichlari bo'lgan 1575 bemor ishtirok etdi; saratonning boshqa potentsial bashoratchilariga moslashgandan so'ng, kolorektal saraton kasalligining o'ziga xos xususiyati aniqlandi o'lim va umumiy o'lim.
Kolorektal saraton tashxisi qo'yilganidan keyin 6 oydan 4 yilgacha tadqiqotchilar umumiy tolani iste'mol qilish, turli xil manbalardan olingan tola miqdori va butun bug'doy miqdorini baholash uchun ovqatlanish chastotasi bo'yicha tasdiqlangan so'rovnomadan foydalandilar.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce kolorektal cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
