Yangi tadqiqot sitokin interleykin-1b (IL-1b) va semirish o'rtasidagi tematik bog'liqlikni tasvirlaydi. Semizlikda IL-1b darajalari ko'tarilsa, IL-1 retseptorlari signalizatsiyasining faollashishi ko'plab yo'g'on ichak saratoniga olib keladi. Yo'llarning turlari. Ushbu tadqiqot shuni ko'rsatadiki, semirish IL-1b ning tizimli ko'payishi, faollashuvi va sichqonchaning yo'g'on ichak hujayralarining ko'payishi bilan bog'liq.
Massachusets shtatidagi Tufts universiteti va Tufts universiteti tibbiyot fakulteti xodimi Djoel Meyson va Tufts universiteti hamkasblari "Interlökin-1 signallari semirishni kuchaytiradigan yallig'lanish sitokinlari, Wnt faollashuvi va kichkina vositalar" kalamush yo'g'on ichak epiteliya hujayralarining ko'payishi "maqolasining muallifi. . "
The researchers set out to determine the role of IL-1β in regulating events leading to obesity-promoting kolorektal saraton. They compared the role of IL-1β in mice fed a high-fat (obese) or low-fat (lean) diet. One of the changes they are found in obese mice having colon mucosa 30-80 % higher concentration of IL-l [beta] , the Wnt cascade significantly increased signal amplification and significantly proliferating crypts in the colon region.
"Ushbu tadqiqot semirish va yallig'lanish reaktsiyasi o'rtasidagi yaqin aloqani ochib beradi va semirishni ko'plab yallig'lanish kasalliklaridan biri sifatida belgilaydigan IL-1β ning keng rolini aks ettiradi", Vashington universiteti immunologiya kafedrasi, Tug'ma immunitet va immunitet kasalliklari markazi. Journal of Interferon & Cytokine Research jurnalining bosh muharriri Maykl Geyl Jr.
