Noyob global klinik tadqiqotlar natijalariga ko'ra, o'smalari va limfa tugunlarini jarrohlik yo'li bilan rezektsiya qilingan yo'g'on ichak saratoni III bosqichli ba'zi bemorlar kimyoterapiyadan keyin standart olti oylik kimyoterapiyani talab qilmasligi mumkin. Bundan farqli o'laroq, ko'plab past xavfli bemorlar uchun uch oylik kimyoterapiya saratonning qaytalanish tezligini sezilarli darajada oshirmaydi va zararli yon ta'sirlarning, shu jumladan oksaliplatin kimyoviy terapiyasi tufayli kelib chiqadigan nervlarning shikastlanishi yoki doimiy og'riq, uyqusizlik va karıncalanmaning oldini oladi.
This is a global trial launched in 2007 on the International Duration Assessment of Adjuvant Chemotherapy (IDEA). Six parallel Phase III trials in 12 countries in North America, Europe and Asia enrolled 12,834 eligible patients. Patients with stage III yo'g'on ichak saratoni usually use FOLFOX or CAPOX chemotherapy for standard treatment after surgery. The researchers randomly assigned patients to treatment groups of three or six months.
Results: Three months of chemotherapy is not suitable for all patients. Instead, the data shows that the duration of chemotherapy should be determined based on the combination of drugs used and the individual characteristics of the patient ’s cancer: the degree of shish deposition on the colon wall and the number of lymph nodes that the cancer has spread to. For low-risk patients-those with shallow tumors and affected lymph nodes-treatment with CAPOX for 3 months has been shown to be safe and effective, with little side effects, the same as the progression-free survival (PFS) of six months of treatment. However, in some cases, a six-month course of treatment is better for high-risk patients.
Ueyn davlat universiteti tibbiyot fakulteti professori doktor Entoni Shildsning aytishicha, amalda men ushbu yangi standartlarni xavfi past yo'g'on ichak saratoni bilan og'rigan bemorlarga qo'lladim, bu ularga davolanish vaqtini tejaydi va toksik ta'sirining oldini oladi. olti oylik kimyoviy terapiya samarasi. Dunyo bo'ylab taxminan 400,000 bemorlar oksaliplatin asosidagi davolashni operatsiyadan keyingi kimyoviy terapiya sxemasi deb hisoblashadi, shuning uchun bu topilmalar juda katta ta'sir ko'rsatadi.
