Singapur Milliy Universitetining Saraton tadqiqotlari instituti (CSI) tadqiqot guruhi gepatotsellyulyar karsinoma (HCC) yoki birlamchi saraton rivojlanishining oldini oladigan FFW deb nomlangan yangi peptid preparatini ishlab chiqdi. jigar saratoni . Ushbu muhim kashfiyot jigar saratonini yanada samarali davolash va nojo'ya ta'sirlarni kamaytirish uchun eshikni ochadi.
SALL4 is a protein associated with tumor growth and has been used as a prognostic marker and drug target for HCC, lung cancer and leukemia. It is usually present in a growing fetus, but is inactive in adult tissues. In some cancers, such as HCC, SALL4 is reactivated, leading to shish o'sish.
SALL4-NuRD kabi oqsillarga ta'sir qiluvchi dori molekulalari, maqsadli oqsilni 3-o'lchovli tuzilishida kichik "cho'ntak" bo'lishini talab qiladi, bu erda dori molekulalari mavjud bo'lishi va ishlashi mumkin. Dastlabki tadqiqotlarda SALL4 oqsilining boshqa oqsil NuRD bilan o'zaro aloqasi borligi aniqlandi, bu esa HCC kabi saraton kasalliklarini rivojlanishida hal qiluvchi ahamiyatga ega. Ushbu tadqiqot guruhi tomonidan ishlab chiqilgan SALL4 "cho'ntaklar" ni qidirmadi, balki SALL4 va NuRD o'rtasidagi o'zaro ta'sirni to'sadigan biomolekulalarni ishlab chiqdi. Tadqiqotlar shuni ko'rsatdiki, ushbu o'zaro ta'sirni blokirovka qilish o'sma hujayralarining o'limiga olib kelishi va o'simta hujayralarining harakatini kamaytirishi mumkin.
FFW can effectively block protein-protein interactions, and does not require “pockets” to take effect. The research team also found that when combined with sorafenib, FFW can reduce the growth of sorafenib-resistant HCC. Although most maqsadli davolash are small-molecule drugs, well-designed peptide drugs (such as FFW) tend to have higher selectivity than large-molecule surfaces and are less toxic than small molecules.
Singapur tadqiqotchisi doktor Liu Bee Xuining aytishicha: Genlarning tuzilishi va global ekspressionidan olingan ma'lumotlarga asoslanib, biz ushbu peptidni va shunga o'xshash tuzilmalarga ega bo'lgan boshqa peptidlarni oxir-oqibat ularni klinik darajadagi dori-darmonlarga aylantirish va bemorlarga foyda keltirish uchun o'rganishni davom ettirmoqdamiz.
