Hindistan'da kemik iliği nakli
Bone marrow stem cell transplants in India are performed by some of the leading cancer centres. To date, more than 10,000 successful bone marrow stem cell transplants have been performed in India. Patients from across the world visit India for bone marrow stem cell transplant.
What is bone marrow stem cell transplant ?
As per NCI dictionary of cancer terms bone marrow transplant is a procedure in which a patient receives healthy blood-forming cells (stem cells) to replace their own stem cells that have been destroyed by disease, radiation or high doses of anticancer drugs that are given as part of the procedure. The healthy stem cells may come from the bone marrow of the patient or a donor. A bone marrow transplant may be autologous (using a patient’s own stem cells that were collected from the marrow and saved before treatment), allogeneic (using stem cells donated by someone who is not an identical twin), or syngeneic (using stem cells donated by an identical twin). Also called BMT.
In simple terms when bone marrow is damaged or destroyed by disease, infection or chemotherapy then it is replaced by new stem cells which travels to the bone marrow where they produce new blood cells and promote growth of new marrow.
Bone marrow is one of the most essential part of the body and creates following parts of the blood :
- red blood cells, which carry oxygen and nutrients throughout the body
- white blood cells, which fight infection
- platelets, which are responsible for the formation of clots
A bone marrow transplant replaces your damaged stem cells with healthy cells. This helps your body make enough white blood cells, platelets or red blood cells to avoid infections, bleeding disorders, or anemia.
Why bone marrow stem cell transplant performed ?
Bone marrow transplants, also knows as BMT, are performed when a patients marrow isn’t healthy enough to function properly. Some of the reasons of bone marrow transplant are :
- Aşırı kansızlık: in this disorder, the bone marrow stops making new blood cells.
- Cancers like leukemia, lymphoma & multiple myeloma affect the bone marrow badly.
- Bone marrow gets damaged due to chemotherapy.
- Congenital neutropenia, which is an inherited disorder that causes recurring infections
- Sickle cell anemia, which is an inherited blood disorder that causes misshapen red blood cells
- Thalassemia is an inherited blood disorder where the body makes an abnormal form of hemoglobin, an integral part of red blood cells.
How is a bone marrow stem cell transplant performed?
Prior to bone marrow transplant, several tests are performed to determine what type of stem cells are required. There is a possibility that the patient undergo chemotherapy or radiation therapy to kill all the cancer cells or marrow cells before they get the new stem cells.
During the course of treatment, there is a huge vulnerability to immune system of the body. This causes the body to fight any kind of infections. Hence, patients are kept in a very special section of the hospital that’s reserved for people receiving bone marrow transplants.
The procedure of a bone marrow transplant is similar to that of a that of a blood transfusion.
If the patient is going for an allogenic transplant, bone marrow cells will be harvested from the donor a day or two before your procedure. If own cells are used, then they are retrieved from the stem cell bank.
During a bone marrow harvest, cells are collected from both hipbones through a needle. You’re under anesthesia for this procedure, meaning the patient will be asleep and free of any pain.
Lökaferez
Leukapheresis is a process in which a donor is given five shots to help the stem cells move from the bone marrow into the bloodstream. Blood is then drawn through an intravenous (IV) line, and a machine separates out the white blood cells that contain stem cells.
A needle called a central venous catheter, or port, will be installed on the upper right portion of the patient’s chest. This allows the fluid containing the new stem cells to flow directly into the patient’s heart. The stem cells then disperse throughout the patient’s body. They flow through the patient’s blood and into the bone marrow. They’ll become established there and begin to grow.
The port is left in place because the bone marrow transplant is done over several sessions for a few days. Multiple sessions give the new stem cells the best chance to integrate themselves into the patient’s body. That process is known as engraftment.
Through this port, you’ll also receive blood transfusions, liquids, and possibly nutrients. You may need medications to fight off infections and help the new marrow grow. This depends on how well you handle the treatments.
During this time, patient is closely monitored for any complications.
Types of bone marrow stem cell transplant
There are two major types of Bone Marrow Transplant. Type of transplant required depends on the reason for which BMT is required.
Autologous Transplants
Autologous transplant use the own bone marrow to replace damaged stem cells. This is done by harvesting your cells before beginning a damaging therapy for them, like chemotherapy or radiation. However, this type of transplant can only be done if you have healthy bone marrow.
Allogenic transplants
Allogenic transplant is done when patient’s bone marrow is completely damaged and unable to function properly. This involves use of cells from the donor. Donor must be close genetic match. HLA typing test is conducted on the donors and patient and then it is matched. However, these patients have very high risk of complications, such as GVHD. Patient is also put on medications to suppress the immune system so that body doesn’t attack the new cells. The success of an allogenic transplant depends on how closely donor cells match the patient’s cells.
Complications associated with bone marrow stem cell transplant
Bone marrow transplant or BMT, is a major medical procedure and lot of precision and care is required along with requisite infrastructure in the hospital to carry out the procedure. One may experience following after BMT –
- a drop in blood pressure
- baş ağrısı
- bulantı
- ağrı
- nefes darlığı
- titreme
- ateş
Apart from the this one may also incur some other complications but generally depends on the age, overall health, disease that’s been treated for and type of transplant one has received.
Complications can be mild or very serious, and they
içerebilir:
- graft-versus-host disease (GVHD), which is a condition in which donor cells attack your body
- graft failure, which occurs when transplanted cells don’t begin producing new cells as planned
- bleeding in the lungs, brain, and other parts of the body
- cataracts, which is characterized by clouding in the lens of the eye
- damage to vital organs
- erken menopoz
- anemia, which occurs when the body doesn’t produce enough red blood cells
- enfeksiyonları
- nausea, diarrhea, or vomiting
- mucositis, which is a condition that causes inflammation and soreness in the mouth, throat, and stomach.
Best hospitals for bone marrow stem cell transplant in India
- BLK Hastanesi, Yeni Delhi
- Artemis Hastanesi, Gurugram, Delhi NCR
- Amerikan Onkolojisi, Haydarabad
- Mazumder Shaw Narayana, Bangalore
- Narayana Çok Uzmanlık Hastanesi, Howrah
- Fortis Hastanesi, Gurgaon
- Apollo Cancer Institute, Hyderabad
- Apollo kanser Enstitüsü, Chennai
- Medanta ilacı, Gurgaon
- Dharamshila Hastanesi, Delhi
Hindistan'da kemik iliği kök hücre naklinin maliyeti
An allogenic, fully matched bone marrow stem cell transplant in India cost approximately $ 25,000 USD Hindistan'da.
Allogenic half match would cost between 29,000 ABD Doları ve 35,000 ABD Doları
Aulogous stem cell transplant will cost between $ 16,000 and $20,000 USD
Bone marrow stem cell transplant in India are commonly performed now. Patients from many countries like USA, UK, Europe, Africa, Bangladesh, Afghanistan, UAE etc now a days come to India for bone marrow stem cell transplant.
BEST DOCTORS FOR BONE MARROW STEM CELL TRANSPLANT IN INDIA
Dr.Dharma Choudhary - BLK Kemik İliği Nakil Merkezi, Yeni Delhi 2000'den fazla başarılı nakil ile kemik iliği kök hücre nakli konusunda Hindistan'ın tartışmasız önde gelen doktorudur. Başarılı bir BMT cerrahı olarak başarılı kariyeri ve Dr. Choudhary'nin Talasemi Kemik İliği Nakli, Talasemi Kök Hücre Nakli konusundaki uzmanlığıyla tanınır. Dr. Dharma Choudhary, Delhi'deki Sir Ganga Ram Hastanesi'nde geçirdiği süre boyunca Talasemi Majör ve Aplastik Anemi için Allojenik Kemik İliği Nakli konusunda yaptığı çalışmalarla Hindistan'da öncüdür. Dr. Dharma Choudhary, Hindistan'da bu neslin en iyi 10 Hematolog ve Kemik İliği Nakli Uzmanı listesine girdi. Kemik İliği Naklindeki Yüksek başarı oranlarıyla tanınan Dr. Dharma Choudhary, Hindistan Hematoloji ve Transfüzyon Tıbbı Derneği'nin ömür boyu üyesidir. Aynı zamanda, çoğunlukla Afganistan, Irak, Umman, Özbekistan, Sudan, Kenya, Nijerya ve Tanzanya olmak üzere dünyanın farklı yerlerinden gelen uluslararası hastalar arasında da popülerdir.
Sanjeev Kumar Sharma is a practising Hematologist with an experience of 19 years. He is located in New Delhi. Dr. Sanjeev Kumar Sharma practices at the Yeni Delhi'de BLK Süper Özel Hastanesi. BLK Süper Özel Hastanesi, 5, Radha Soami Satsang Rajendra Place, Pusa Yolu, Yeni Delhi adresinde yer almaktadır. Sanjeev Kumar Sharma, Tescilli üye Indian Society of Hematology and Blood Transfusion (ISHTM) 'nin değerli bir üyesi, Delhi Medical Association (DMA) Kayıtlı üyesi Indian Society of Hematology and Blood Transfusion (ISHTM), Delhi Medical Association'ın Kayıtlı üyesi ( DMA) ve Hint Ateroskleroz Araştırmaları Derneği (ISAR) Üyesi.
He pursued his MBBS in the year 1999 from University Of Delhi, Delhi. He completed his MD in the year 2006 from University Of Delhi, Delhi. He has also done his DM in the year 2012 from All India Institute Of Medical Sciences, New Delhi.
.Dr Sanjeev has been awarded with Best Citizen of India Award.
Doktor Revathi Raj bir Hematolog ve Çocuk Doktorudur Apollo Hastanesi, Teynampet, Chennai ve bu alanlarda 24 yıllık tecrübeye sahiptir. Dr. Revathi Raj, Teynampet, Chennai'deki Apollo Özel Kanser Hastanesi ve Thousand Lights, Chennai'deki Apollo Çocuk Hastanelerinde çalışmaktadır. 1991'de Madras Üniversitesi, Chenai, Hindistan'dan MBBS'yi, 1993'te The Tamil Nadu Dr.MGR Tıp Üniversitesi'nden (TNMGRMU) Çocuk Sağlığı Diplomasını (DCH) ve 2008'de The Royal College of Pathologist'ten FRC.PATH. Hindistan Tıp Derneği (IMA) üyesidir. Doktor tarafından verilen hizmetlerden bazıları şunlardır: Eozinofili Tedavisi, Boyun Ağrısı Tedavisi, Şelasyon Tedavisi, Biyokimya ve Kan Transfüzyonu vb. Dr Revathi, ülkedeki en büyük kemik iliği nakil serilerinden biri olarak kabul edilmektedir. Hemofili ve orak hücre hastalığını başarıyla tedavi etti. Çocuklarda kan hastalıkları konusunda uzman ilgisi vardır.
Dr. Sharat Damodar - Narayana Kemik İliği Nakil Merkezi, Bangalore Dr. Sharat Damodar completed his MBBS from St. Johns Medical College, Bangalore and later completed his MD from DNB college. He is currently serving as Vice President of Mazumdar Shaw Medical Centre, Narayana Health City. He is a celebrated Oncologist who has performed more than 1000 Bone Marrow & Stem Cell Transplants and also won Chairman’s Award for Best Doctor in 2015. Dr. Sharat field of expertise is bone marrow & stem cell transplant, cord blood transplantation & lymphoma. Key procedures performed by Dr. Sharat Damodar are Bone marrow & stem cell transplant, cord blood transplantation, leukemia / lymphoma. Dr. Sharat has performed more than 1000 successful bone marrow stem cell transplants in his career til date.
Dr. Ramaswamy NV at Aster Medcity, Koçi is a Hematologist with more than 18 years of experience, Dr. Ramaswamy is an expert in management of malignant and non-malignant diseases of the blood, in patients of all ages. His areas of special interest are hemato oncology and stem cell transplant. Dr. Ramaswamy is expert in bone marrow stem cell transplant, prostate cancer, lung cancer, stomach cancer, colon cancer, & blood related disorders. He is specially interested in immunosuppressive drugs, targeted therapy, hodgkins lymphoma, myeloma, lymphoma, strocytoma, osteosarcoma, stereotactic radiosurgery, blood cancer, leukemia, sickle-cell anemia, germ cell tumour (GCT), thalassemia, non hodgkin lymphoma, and all forms, type and stages of cancer.
Dr. Pawan Kumar Singh - Artemis, Gurugram, Delhi (NCR) is having experience of performing more than 300 bone marrow transplants (including Autologous/Allogenic/Haplo/MUD) for both malignant and non-malignant blood disorders including thalassemia and aplastic anaemia. Done successful Haplo BMT for SCID in an 8 months old child. Successfully done MFD BMT for HLH in a 2 yr old child.
Individually set up BMT unit at Jaypee Hospital and made SOPs for each and every important steps for successfully running the BMT unit. Made BMT UNIT at Jaypee hospital the transplant centre for MUD transplant and got PBSC product from national (Datri) and international registry (DKMS).
Performed 50 BMTs in last 18 months at Jaypee hospital (MSD/MFD-20; Haplo-6; Auto-2 and MUD-4).
Dr Joydeep Chakrabartty – Kolkata Kalküta'daki tanınmış bir üniversiteden MBBS'sini tamamladı ve ardından yüksek lisans eğitimi için Birleşik Krallık'a gitti. Kariyeri boyunca MRCP (İngiltere) ve FRC PATH (İngiltere) ve FRCP (Glasgow) kimlik bilgilerini almaya devam etti. İkincisi, Tıp alanında hizmetlere liderlik etme ve kurma rolünden dolayı ödüllendirildi. Kemik İliği Transplantasyonu (BMT) alanlarına, özellikle Akut Lösemiler başta olmak üzere tüm koşullar için yanlış eşleştirilmiş yüksek son nakil alanlarına özel bir ilgisi vardır. St Bartholomews Hastanesi de dahil olmak üzere Birleşik Krallık'ta tanınmış enstitülerde ve Londra'daki The Imperial College, Hammersmith Hastanesi'nde prestijli Kemik İliği Nakli Bursu'nda çalıştı.
Dr. Joydeep Chakrabartty has worked for many years in Medicine and in reputed Critical care units before taking up Hematology. He has encountered and managed not only all hematological emergencies and conditions but his previous general medicine and ICU exposure gives him the edge in managing very sick patients i.e. patients undergoing Bone Marrow Transplant, Acute Leukemia’s etc. He is also very competent in the laboratory diagnostic part of hematological diseases. Upon his return, Dr. Chakrabartty helped in the formation and successful running of many Bone Marrow Transplant departments across the country. Dr. Joydeep Chakrabartty has written many articles for leading journals and has also written chapters in text books.
Doktor Radheshyam Naik at Bangalore alanında 25 yılı aşkın güçlü akademik tecrübesi ile Tıbbi Onkoloji alanında öncüdür. MD Anderson Cancer Institute, ABD, International School for Cancer Care, Oxford, UK, University of New South Wales, Australia gibi dünyanın önde gelen kurumlarından ileri eğitim aldı.
Seçkin bir onkolog olarak kabul edilen ve dünyanın dört bir yanındaki ünlü kanser hastanelerini ziyaret etme deneyimine sahip olan Dr. Radheshyam, önde gelen dergilerde hakemli yayınlar ile her tür kanser ve hematolojik bozukluğun yönetiminde mükemmel bir akademik kariyere sahiptir. Ulusal ve uluslararası denemelerde 50'den fazla kemoterapi ilacı yürütülen çeşitli İlaç denemelerinin yürütülmesinde öncüdür.
Kemik İliği Nakli programına özel ilgisi var ve ayrıca İsrail Hadassah Üniversitesi'nde ileri eğitimler aldı; Detroit tıp merkezi, New York hastanesi ABD, Cornell Tıp merkezi ve Harper Hastanesi, Michigan, ABD.
Dr. Radheshyam, Karnataka'da Hematoloji ve Kemik İliği Transplantasyonu alanının geliştirilmesinde önemli bir katkıda bulunmuştur. Karnataka limanından ilk intraarteryel kemoterapiyi gerçekleştirdi ve aynı zamanda Karnataka'da ilk Kemik İliği Transplantını gerçekleştirdiği için kredilendirildi.
Dr Shrinath Kshirsagar hematolog / hemato-onkolog ve kemik iliği nakli doktorudur. Mumbai. He has over 8 years of experience in this field. He has completed his super-specialty training from prestigious Tata Medical Center. He was a part of team which did more than 200 bone marrow transplants over two years. He has many national and international publications. He was principle investigator in one of the clinical trial in the field of leukemia.Key procedures performed by Dr. Srinath are Bone marrow & stem cell transplant, cord blood transplantation, leukemia / lymphoma. Significant advances have been made in understanding the biology of Leukemia over the last few decades. This has translated to recognition of novel targets for therapy, novel therapeutic options and targeted therapy which have in turn significantly improved the clinical outcomes of patients with Leukemia. Dr. Shrinath Shirsagar is the well Experienced doctor for such advanced Leukemia and Lymphoma treatment in Mumbai. 8 yıllık tecrübesiyle özellikle immünsüpresif ilaçlar, hedefe yönelik tedavi, hodgkins lenfoma, miyelom, lenfoma, strocytoma, osteosarkom, stereotaktik radyocerrahi, kan kanseri, lösemi, orak hücreli anemi, germ hücreli tümör (GCT), talasemi, hodgkin olmayan lenfoma ve kanserin tüm formları, tipi ve evreleri.
