British scientists begin genetic testing of childhood tumors. British scientists hope that genetic testing will give younger patients newer and more personalized treatments that will increase their survival. The new test analyzes 81 different cancer genetic changes.
Scientists say the test will lead to “a higher level of playing field” and accelerate children’s access to important new drug treatments. The test was performed at the Royal Marsden National Health System Hospital in London and will be tested on 400 children from all over the UK over the next two years.
The test has been implemented with genetic funding from the National Institutes of Health (NIHR) foundation and the Kanser Institute. A charity called Christopher has provided more than £ 300,000 in funding to develop the test. The organization was founded by a couple whose children died of invasive mga bukol ng utak at the age of six.
This is a real first step towards personalized panggamot sa kanser for children,” said Christopher’s parents, Karen and Kevin Capel. Christopher got a generic pamamaga. Hopefully, in the future, children will know exactly what type of tumor they have.” “We almost feel that the treatment for the child is not to kill the cancer, but to kill our child.”
“He used to be a healthy, happy, very athletic 4-year-old kid. But he became unable to speak or even eat on his own, and lost weight. “In the year he was diagnosed, he was unable to grow into a child of his age. We tried to keep him from other children.”
Ang mga malignant na tumor ay napakabihirang sa mga bata, walang maraming populasyon ng pasyente, at clinical trials for pharmaceutical companies will lack motivation. This means that children will miss the opportunity to receive targeted treatments for cancer cells without damaging healthy cells with innovative therapies.
Professor Louis Chesler, who is leading the genetic testing research, said: “Children often don’t have equal access to the most advanced and potentially beneficial cancer treatments.” “The cost of developing gene-targeted drugs is very high. They tend to Test it on adults first so that more people can get treatment and the results can be seen faster. ”
"Ang pagsubok na ito ay isang hindi kapani-paniwalang pagsulong dahil malinaw na makikilala nito ang lahat ng mga pagbabago sa genetiko sa bukol." "Ang pagsusuri sa gene ay nagbibigay sa mga klinika ng isang napakalakas na tool - pagtulong sa kanila na pumili ng tamang gamot para sa kanilang mga anak at gawin ang kanilang makakaya. Maaaring posible upang mabilis na matukoy ang pagiging epektibo ng mga gamot na ito. "
Children’s tumors are usually genetically simpler than adult tumors, so eventually these drugs may be more effective in children.” The goal of genetic testing is to give scientists and doctors detailed genes for childhood tumors within a few weeks of diagnosis. information.
Genetic testing gives doctors strong evidence to use naka-target na mga therapy for younger patients, potentially preventing these patients from experiencing the side effects associated with traditional chemotherapy and radiation therapy.
Jack Daly, 14, from Wokingham, was diagnosed with a brain tumor when he was 7 and is now a brain tumor survivor. Radiotherapy helped save his life, but left him with sequelae. “My athletic ability is not very good,” Jack said. “I have to get someone to help me dress and undress at school.” “My balance is not good-I am awkward and often fall. I worked hard at school, where I found friendship.” Jack and his mother, Helen, use their donations to make ends meet in Capels-hoping that genetic testing will make a huge difference in the quality of life of future children.
"Hindi talaga nakikita ng mga tao ang problema dahil nakagaling si Jack mula sa cancer. Hindi niya kailangan na nasa isang wheelchair. Hindi niya kailangang magsuot ng bendahe, ”Helen said.
“Kung nakita mo ba si Jack, para siyang normal na teenage boy. Ngunit ang hindi mo nakikita ay ang pinsala sa tisyu ng utak na sanhi ng paggamot. "
Pinagmulan ng URL ng artikulong ito: http://www.bbc.com/news/health-35918744
