According to the results announced at the 2018 ASCO annual meeting, the CDK4/6 inhibitors pabociclib (Ibrance) and cetuximab (Erbitux) combined treatment of platinum-resistant and HPV-independent recurrent/metastatic head and neck The overall response rate for patients with squamous cell carcinoma (HNSCC) is 39%. In a non-randomized, 3-arm, phase II trial (NCT02101034), the results of a group of studies have a median progression-free survival (PFS) of 5.4 months, a median overall survival (OS) of 9.5 months, and a 1-year OS The rate is 35%.
In this study, 30 patients with HNSCC unrelated to HPV progressed after platinum-based therapy for relapsed/metastatic disease and participated in the trial. Patients who had previously received cetuximab for relapse and HPV-related oropharyngeal cancer were not eligible. Patients received palbociclib from day 1 to day 21, 125 mg daily; cetuximab, with a starting dose of 400 mg/m 2 and then 250 mg/m 2 per week for a period of 28 days until the disease progressed or withdrew the study. The researchers performed imaging examinations before treatment and after every 2 cycles.
Medianåldern för patienterna var 67 år och tumörställena var munhåla (47 %), struphuvud (27 %) och orofarynx (13 %). 20 % av patienterna har lokala regionala metastaser, 27 % har fjärrmetastaser och 53 % har båda. Femton (50 %) patienter fick ≥ 2 behandlingar.
Av de 28 utvärderbara patienterna hade 11 (39%) tumörsvar, inklusive 3 (11%) fullständiga svar och 8 (29%) partiella svar. Fjorton (50 %) patienter hade stabil sjukdom, 3 (11 %) patienter hade progression och 70 % hade minskade tumörskador.
Researcher Dr. Adkins said that Palbociclib and cetuximab have strong antitumor activity in platinum-resistant HPV-independent head and neck cancer, and biologically targeted therapy for HPV-independent head and neck cancer is an effective treatment strategy. . We look forward to the better results of the follow-up research.
