According to the results announced at the 2018 ASCO annual meeting, the CDK4/6 inhibitors pabociclib (Ibrance) and cetuximab (Erbitux) combined treatment of platinum-resistant and HPV-independent recurrent/metastatic head and neck The overall response rate for patients with squamous cell carcinoma (HNSCC) is 39%. In a non-randomized, 3-arm, phase II trial (NCT02101034), the results of a group of studies have a median progression-free survival (PFS) of 5.4 months, a median overall survival (OS) of 9.5 months, and a 1-year OS The rate is 35%.
In this study, 30 patients with HNSCC unrelated to HPV progressed after platinum-based therapy for relapsed/metastatic disease and participated in the trial. Patients who had previously received cetuximab for relapse and HPV-related oropharyngeal cancer were not eligible. Patients received palbociclib from day 1 to day 21, 125 mg daily; cetuximab, with a starting dose of 400 mg/m 2 and then 250 mg/m 2 per week for a period of 28 days until the disease progressed or withdrew the study. The researchers performed imaging examinations before treatment and after every 2 cycles.
Средња старост пацијената била је 67 година, а места тумора су била усна дупља (47%), ларинкс (27%) и орофаринкс (13%). 20% пацијената има локалне регионалне метастазе, 27% има удаљене метастазе, а 53% има обоје. Петнаест (50%) пацијената је примило ≥ 2 третмана.
Од 28 процењивих пацијената, 11 (39%) је имало туморске одговоре, укључујући 3 (11%) комплетних одговора и 8 (29%) делимичних одговора. Четрнаест (50%) пацијената је имало стабилну болест, 3 (11%) пацијента је имало прогресију, а 70% је имало смањене туморске лезије.
Researcher Dr. Adkins said that Palbociclib and cetuximab have strong antitumor activity in platinum-resistant HPV-independent head and neck cancer, and biologically targeted therapy for HPV-independent head and neck cancer is an effective treatment strategy. . We look forward to the better results of the follow-up research.
