Waa maxay MRD daawaynta kansarka?
Cudurka haraaga ah ee la qiyaasi karo, ama MRD, waa magaca unugyada kansarka ee aadka u yar ee ku sii jira jidhka ka dib ama inta lagu jiro daaweynta. Sitometry socodka, falcelinta silsiladda polymerase (PCR), ama isku xigxiga jiilka xiga ayaa ah farsamooyin xasaasi ah oo heli kara unugyadan kansarka xitaa marka hababka ogaanshaha caadiga ah, sida sawir-qaadista, aysan awoodin.
La socodka MRD aad ayey muhiim u tahay go'aan ka gaarista sida loo daweeyo noocyada kala duwan ee kansarka dhiigga, sida lymphoblastic leukemia (DHAMMAAN), acute myeloid leukemia (AML), myeloid leukemia chronic (CML), lymphomas, iyo myeloma badan. Waxay kaa caawinaysaa in la ogaado sida ay u badan tahay in qof soo laaban karo oo loo isticmaali karo in lagu beddelo qorshooyinka daawaynta marka loo baahdo.
Marka uu qof qabo kansar, MRD waxaa loo isticmaalaa si loo arko sida wanaagsan ee daawadu u shaqeyso iyo in lagu caawiyo qorsheynta daweyno badan. Tusaale ahaan, haddii MRD la helo daawaynta koowaad ka dib, waxay la macno noqon kartaa in kansarku aanu si fiican uga jawaabin daawaynta hadda jirta oo loo baahan yahay in isbeddello la sameeyo. Haddii, dhanka kale, MRD la joojiyo in la helo daawaynta ka dib, waxay la macno tahay in kansarku aanu sii korin oo daawadu ay shaqaynayso.
Marka la soo koobo, MRD waa fikrad muhiim u ah daaweynta kansarka sababtoo ah waxay ka caawisaa in la ogaado sida wanaagsan ee daaweyntu u shaqeyso waxayna caawisaa qorsheynta daaweynta mustaqbalka. Waa lagama maarmaan in lala socdo koritaanka dadka leh noocyada kala duwan ee kansarka dhiigga waxaana loo isticmaali karaa in lagu qiyaaso sida ay u badan tahay in kansarku soo noqdo.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T-Cell daaweynta Shiinaha
Sidee MRD lagu ogaadaa bukaanka kansarka?
Sitometry socodka, falcelinta silsiladda polymerase (PCR), ama taxanaha jiilka soo socda ayaa ah habab gaar ah oo loo isticmaalo in lagu helo Cudurka haraaga ah ee la qiyaasi karo (MRD) bukaanka kansarka. Siyaabaha dhaqameed ee lagu ogaado kansarka waxa laga yaabaa inay seegaan tiro aad u yar oo unugyada kansarka ah oo hababkani ay heli karaan. Tijaabada MRD aad ayay muhiim u tahay in lala socdo sida wanaagsan ee daaweynta kansarku u shaqeyso iyo qorsheynta daawaynta cusub.
Burooyinka adag, aqoonsiga MRD ayaa lagama maarmaan u ah in la helo bukaanno weli leh nabarro qalliinka ka dib. Qiyaastii 10 ilaa 15 boqolkiiba bukaannadan waxay u baahan yihiin in si dhow loo eego. Aad bay muhiim u tahay in isha lagu hayo MRD dadka qaba kansarka dhiigga sida ALL, AML, CML, lymphomas, iyo multiple myeloma si ay takhaatiirtu u sameeyaan doorashooyin ku saabsan daaweynta oo ay qiyaasaan sida bukaanku samayn doono.
Guud ahaan, helitaanka MRD ee bukaannada kansarka waxay la macno tahay in la isticmaalo habab casri ah oo xasaasi ah si loo helo unugyo kansar oo laga yaabo in aan laga helin habab hore. Dabagalkan ayaa aad muhiim ugu ah in la ogaado sida wanaagsan ee daawadu u shaqaynayso iyo waxa ay tahay in la qaado tillaabooyinka kale ee daaweynta.
Waa maxay hababka caadiga ah ee loo isticmaalo in lagu ogaado MRD bukaanka kansarka?
Qaar ka mid ah siyaabaha caadiga ah ee lagu helo Cudurka haraaga ah ee la qiyaasi karo (MRD) Bukaanada kansarka qaba waa:
1. Cytometry socodka: Habkani wuxuu eegayaa sifooyinka unugyada muunada si loo helo unugyo aan caadi ahayn oo macnaheedu noqon karo MRD ayaa jooga.
2. Falcelinta Silsiladda Polymerase (PCR): PCR waa hab molecular loo isticmaalo in lagu helo oo koobiyeeyo qaabab DNA oo gaar ah, kaas oo u ogolaanaya saynisyahannadu inay ka helaan tiro yar oo unugyo kansar ah muunad.
3. Taxanaha Jiilka Xiga (NGS): NGS waa qalab isku xigxig heersare ah oo heli kara isbeddellada hidde-sidaha ee ku xidhan kansarka. Tani waxay kaa caawinaysaa in la helo MRD oo leh dareen sare iyo gaar ahaaneed.
Hababkan ayaa aad muhiim ugu ah in isha lagu hayo bukaanka kansarka inta lagu jiro daawaynta ka dib. Waxay gacan ka geystaan sidii loo ogaan lahaa sida wanaagsan ee daawadu u shaqeysay, qiyaas waxa dhici doona, iyo qorsheynta daawayno badan.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T-Cell therapy Qiimaha ee Shiinaha
Waa maxay muhiimada MRD ee daawaynta unug ee CAR T?
Cudurka haraaga ah ee la qiyaasi karo (MRD) waa qayb aad muhiim u ah Daaweynta unugyada CAR T sababtoo ah waxay ka caawisaa dhakhaatiirta inay ogaadaan sida wanaagsan ee daaweyntu u shaqeyn doonto iyo natiijooyinka la filayo. Daraasaduhu waxay muujiyeen in ka takhalusida MRD ka dib CAR T-cell daaweynta waxay kordhin kartaa fursada nolosha, gaar ahaan dadka jawaabta MRD aysan u fiicneyn sidii ay ahaan lahayd. Cilmi-baarayaashu waxay sidoo kale eegayaan baaritaannada MRD si ay u saadaaliyaan soo noqoshada hore oo ay u arkaan sida wanaagsan ee daaweyntu u shaqeyso ka dib CAR T-cell daaweynta.
Leukemia ba'an ee lymphoblastic (ALL), MRD waxay noqotay calaamad muhiim u ah saadaalinta natiijada cilmi-baarista iyo ogaanta cidda khatarta ku jirta, gaar ahaan marka ay timaado daaweynta CAR T-cell. Tijaabada MRD ee wanaagsan ka hor inta aan la tallaalin ayaa lala xiriiriyay natiijooyin caafimaad oo wanaagsan oo ku saabsan daawaynta CAR-T oo ay raacdo haploidentical hematopoietic stem cell transplantation ee dib u soo noqoshada ama dib u soo celinta leukemia ba'an ee lymphoblastic. Tani waxay muujinaysaa sida ay muhiimka u tahay baaritaanka MRD ee guusha daaweynta.
Guud ahaan, qiimaynta MRD waa qayb muhiim ah oo ka mid ah Daaweynta unugyada CAR T sababtoo ah waxay ka caawisaa dhakhaatiirta inay la socdaan falcelinta daawaynta, saadaaliyaan soo noqoshada, iyo habaynta qorshayaasha daawaynta si loo helo natiijooyinka ugu fiican ee bukaan kasta.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T-Cell therapy for multiple myeloma gudaha Shiinaha
MRD ma tahay mid taban oo lama huraan ah ka hor daaweynta Unugyada CAR T?
Ka takhalusidda MRD waa muhiim ka hor daawaynta unugyada CAR T sababtoo ah waxaa la muujiyay inay hagaajinayso natiijooyinka bukaanka iyo heerka badbaadada. Daraasaduhu waxay muujinayaan in daawaynta CAR-T ay si guul leh uga takhalusi karto MRD oo ay kordhiso badbaadada dadka jawaabta MRD aysan u fiicneyn sida ay noqon karto. Sidoo kale, samaynta baaritaanka MRD taban ka hor inta aan la tallaalin ayaa lala xiriiriyay natiijooyin caafimaad oo wanaagsan oo ku saabsan daaweynta CAR-T ee loogu talagalay leukemia ba'an ee lymphoblastic oo dib u soo noqday ama joojisay ka jawaabista daaweynta. Sidoo kale, haddii MRD uu sii joogo ama uu soo laabto daawaynta ka dib, waxay ka caawin kartaa dhakhaatiirta inay qiyaasaan marka unugyada B-cell ee ba'an ee lymphoblastic leukemia ay dib u soo noqon doonaan. Xaaladda myeloma, cabbirka hore ee heerka MRD ee dhuuxa lafta ayaa ah tilmaame wanaagsan oo badbaado ah oo ku jira daaweynta CAR-T. Markaa, ka hor inta aan la helin diidmo MRD Daaweynta unugyada CAR T waa qayb weyn oo ka mid ah samaynta daaweyntu si fiican u shaqeyso iyo hagaajinta natiijooyinka bukaanka.
