August 2023: Kansarka mindhicirka dheef-shiid kiimikaadka (mCRC) ee hore loogu daweeyay fluoropyrimidine, oxaliplatin, iyo irinotecan-ku-salaysan kiimiko, daawaynta bayoolojiga ka-hortagga-VEGF, iyo haddii RAS-nooca duurjoogta ah, daawaynta ka-hortagga EGFR, Maamulka Cuntada iyo Dawooyinka ayaa oggolaaday. trifluridine iyo tipiracil (LONSURF, Taiho Oncology, Inc.). LONSURF, daawo hal wakiil ah, ayaa hore u heshay oggolaanshaha FDA ee isticmaalkan Sebtembar 2015.
Qorraxda (NCT04737187), calaamad aan kala sooc lahayn, calaamad furan, xarun badan, tijaabo caalami ah marka la barbar dhigo LONSURF oo leh bevacizumab iyo wakiilka keliya ee LONSURF ee bukaannada 492 ee qaba kansarka mindhicirka metastatic kuwaas oo helay ugu badnaan laba nooc oo kiimiko daaweyn hore ah oo muujiyay horumarka cudurkooda ama dulqaad la'aanta nidaamkii ugu dambeeyay, badbaadada iyo waxtarka ayaa la qiimeeyay.
Guud ahaan badbaadada (OS) iyo badbaadada-horumar la'aanta (PFS) ayaa ahaa cabbirada natiijada waxtarka ee muhiimka ah. Bukaannada loo qoondeeyay LONSURF oo lagu daray bevacizumab cududda tijaabada ayaa muujisay horumar OS ah oo la taaban karo marka la barbar dhigo bukaannada loo qoondeeyay gacanta LONSURF (Hazard ratio 0.61; 95% CI: 0.49, 0.77; 1-sided p0.001). Dhexdhexaadiyaha OS ee LONSURF iyo cududda bevacizumab waxay ahayd 10.8 bilood (95% CI: 9.4, 11.8) iyo cududda LONSURF waxay ahayd 7.5 bilood (95% CI: 6.3, 8.6). Gudaha LONSURF iyo cududda bevacizumab, dhexdhexaadiyaha PFS wuxuu ahaa 5.6 bilood (95% CI: 4.5, 5.9), halka gacanta LONSURF, ay ahayd 2.4 bilood (95% CI: 2.1, 3.2) (Samiga khatarta: 0.44; 95% CI: 0.36, 0.54; 1-dhinac p0.001).
Neutropenia, dhiig-yaraan, thrombocytopenia, daal, lallabbo, AST oo kordha, ALT oo kordha, fosfatase alkaline oo yaraada, soodhiyamka oo yaraada, shuban, calool xanuun, iyo rabitaanka cuntada oo yaraada ayaa ah dhacdooyinka ugu badan ee dhinaca ama cilladaha shaybaarka ee LONSURF oo leh bevacizumab (20%).
Maalmaha 1 ilaa 5 iyo maalmaha 8 ilaa 12 ee wareeg kasta oo 28-maalmood ah, qiyaasta lagu taliyey ee LONSURF waa 35 mg/m2 oo afka laga qaato laba jeer maalin kasta cunto. Faahfaahinta ku saabsan qiyaasta bevacizumab, la tasho macluumaadka laguu qoray.
Eeg macluumaadka dawaynta buuxda ee LONSURF.
