Shalay, FDA-da Mareykanka waxay ku dhawaaqday oggolaanshaha Seattle Genetics 'ka-hortagga-daawoyinka-ka-hortagga-daawoyinka Adcetris (brentuximab vedotin) oo ay weheliso kiimoterabi loogu talagalay bukaannada hore loo daweeyay heerka III ama IV-ga Hodgkin's lymphoma (cHL). Oggolaanshahani wuxuu matalayaa hagaajinta qorshaha daaweynta bilowga ah ee hogkin lymphoma oo horumarsan oo lagu soo bandhigay barashada daaweynta in ka badan 40 sano kahor.
Lymphoma waa nooc kansar ah oo ka bilaabma nidaamka lymfatic. Nidaamka difaaca jirka waxa uu ka caawiyaa jirka in uu la dagaallamo caabuqyada iyo cudurrada. Lymphoma waxay ka soo bixi kartaa meel kasta oo jirka ah waxayna ku faafi kartaa qanjidhada u dhow. Waxa loo qaybiyaa laba nooc: Lymphoma Hodgkin iyo lymphoma non-Hodgkin. Inta badan bukaanada qaba Hodgkin qanjiro ka tirsan yihiin nooca caadiga ah. Noocan ah qanjidhada qanjidhada, waxaa jira lymphocytes aan caadi ahayn oo waaweyn (nooc ka mid ah unugyada dhiiga cad). Waxaa loo yaqaan unugyada Reed-Sternberg. Wax ka qabadka hore, bukaanada qaba Hodgkin's lymfoma caadi ahaan waxay helayaan cafis waqti dheer ah.
Tijaabada caafimaad, awooda Adcetris ee lagu daaweynayo lymphoma-ka caadiga ah ee Hodgkin ayaa la ansaxiyay - cilmi baarayaashu waxay qoreen bukaanada la daweeyay 1,334 kuwaasoo horey u helay celcelis ahaan koorsooyinka 6 ee wareegyada 28-maalin kahor. Intaas ka dib, waxay u kala qaybsameen laba kooxood, koox baa heshay Adcetris iyo kemotherabi (AVD), kooxda kalena waxay heleen oo keliya dawaynta kimikalka (ABVD). Daraasaduhu waxay muujiyeen in bukaanada qaata daaweynta isku dhafka ah ay leeyihiin 23% khatarta hoose ee cudurka, horumarka, ama baahida loo qabo in la bilaabo daaweyn cusub marka loo eego bukaanada kaliya qaata daaweynta kiimikada.
Adcetris wuxuu isku daraa unugyada difaaca jirka iyo daawooyinka, taas oo u oggolaanaysa unugyada difaaca inay u hagaan daawooyinka unugyada lymphoma loo yaqaan CD30, oo loo oggolaaday daawaynta Hodgkin lymphoma classic soo laabatay, Hodgkin lymphoma classic oo leh halis sare oo soo noqoshada ama horumarka ka dib unugyada unugyada taranka, la aqbalay Nidaamka anaplastic cell lymphoma weyn oo daawaynta kale aan waxtar lahayn, iyo asaasiga aasaasiga ah ee anaplastic unug weyn oo lymphoma ah oo aan lahayn. la shaqee daawayn kale.
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm601935.htm
