Jaamacadda Athens Strati A et al. ayaa sheegay in haddii PD-L1 ay si xad dhaaf ah ugu badan tahay unugyada burooyinka wareega (CTC) ay ku siin karto macluumaad macquul ah oo muhiim ah oo loogu talagalay bukaanada qaba kansarka unugyada squamous cell. Daaweynta ka dib, bukaanada qaba PD-L1 togan ee CTC ee helaya daawaynta xakamaynta adjuvant PD1 waxay mudan yihiin qiimayn dheeraad ah. (Ann Oncol. 2017; 28: 1923-1933.)
Based on the tumor’s biological markers, it can be determined whether PD 1 checkpoint inhibitors may ultimately benefit some patients with madaxa iyo luqunta squamous cell carcinoma. The molecular characteristics of circulating buro cells are critical for studying targeted therapy of tumors, and the biomarkers that predict PD 1 checkpoint inhibitors are still unclear. This prospective study included a group of patients with head and neck squamous cell carcinoma who were being treated to evaluate whether circulating tumor cells that overexpress PD-L1 can be detected at baseline (before treatment) and at different treatment time points to predict treatment After the clinical effect.
Cilmi baadhayaashu waxay soo saareen qalab aad xasaasi u ah oo gaar ah oo RT-qPCR ah oo loogu talagalay in lagu ogaado muujinta PD-L1 mRNA ee unugyada CTC-da ee EpCAM. Daraasadu waxay diiwaan gashatay 113 bukaan oo qaba kansarka unugyada madaxa iyo qoorta oo horumarsan waxaana lagu ogaadey PD-L1 muujinta EpCAM-positive CTC unugyada asaasiga ah, ka dib wareegyada 2 ee kiimiko-dabiiciga ah (6 toddobaad), iyo ka dib kiimiko (15 toddobaad) Heerka.
Natiijooyinka waxay muujiyeen in aasaasiga ah, 25.5% (24/94) bukaanada ay qabaan PD-L1 xad-dhaaf ah oo ku saabsan CTCs-kooda. Qiyaasta xad-dhaafka ah ee xad-dhaafka ah ka dib daaweynta kemotherabi induction waxay ahayd 23.5% (8/34), iyo 22.2% (12/54). Daaweynta ka dib, bukaanada qaba CTC wali waxay si xad dhaaf ah u muujinayaan PD-L1 waxay leeyihiin badbaado horumar la'aan-gaaban (P = 0.001) iyo guud ahaan badbaadada guud (P <0.001).
Daaweynta ka dib, PD-L1 iyada oo aan si xad dhaaf ah loo muujin waxay u badan tahay inay gaarto dhammaystirka (AMA = 16, 95% CI 2.76 ~ 92.72; P = 0.002).
