Tijaabada hida sidaha kansarka caloosha
Ka dib ku dhawaad toban sano oo korriin ah, baaritaanka hidda-socodka burooyinka ayaa noqday baahida degdegga ah ee tiro badan oo bukaannada kansarka ah. Tilmaanta warbixinta tijaabada ah ee ay bixiso baadhista hidde-sidaha buro waxay si fiican ugu habboon tahay fikradda horumarinta ee daawaynta saxda ah, waxayna dhex gashay dhammaan dhinacyada ogaanshaha iyo daawaynta bukaanka burooyinka. Bukaannada, waxay u dooran karaan dawooyinka la beegsanayo daawaynta saxda ah, ka fogaanshaha leexinta, iyo iska ilaalinta waxyeellooyinka aan loo baahnayn. qadhaadh.
Xaaladda hadda ee daaweynta la bartilmaameedsaday ee kansarka caloosha
In most cases, surgery is still the main treatment for gastric cancer. However, the heterogeneity of gastric cancer is very strong, and its biological behavior is affected by the huge gene regulation in the cell. Therefore, only by classifying the essential characteristics of gastric cancer from the molecular level can early diagnosis and prognosis judgment of the buro be more reasonable and accurate , Application of molecular targeted drugs for individualized and precise treatment of patients.
Waqtigan xaadirka ah, ka dib daroogada la bartilmaameedsaday waa la oggolaaday:
| Nambarada taxan | Target | daroogada |
| 1 | HER2 | Trastuzumab (Trastuzumab, Herceptin) |
| 2 | VEGFR | Ramucirumab |
| 3 | NTRK | Larotrectinib (LOXO-101) |
| 4 | PD-1 | Pembrolizumab (daawoyinka K) |
| 5 | VEGFR-2 | Apatinib (Apatinib, Aitan) |
Intaa waxaa dheer, waxaa jira daawooyin kale oo badan oo lala beegsado kansarka caloosha ee tijaabooyinka kiliinikada, sida daawooyinka xannibaya HER2: lapatinib (Tykerb ®), pertuzumab (Perjeta ®) iyo trastuzumab emtansine (Kadcyla ®). Daawooyinka xannibaya EGFR: Panitumumab (Victibi®) waa daawo bartilmaameed u ah EGFR oo laga baarayo kansarka caloosha.
Shabakada Caalamiga ah ee Oncologist waxay xasuusinaysaa qof walba in baaritaanka hidda-socodka loo baahan yahay kahor daawaynta la beegsanayo . Kaliya marka la fahmo nooca isbeddelka hidde-sidaha burooyinka ayaa la samayn karaa qorshe daawayn macquul ah si looga faa'iidaysto bukaanka. Intaa waxaa dheer, xulashada tignoolajiyada tijaabada hidaha, waxaa lagama maarmaan ah in la doorto tignoolajiyada tijaabada ku habboon iyadoo loo eegayo bartilmaameedkeeda u dhigma. Kaliya doorashada alaabada uu ansixiyay Maamulka Cuntada iyo Dawooyinka ee Gobolka ayaa saxnaanta iyo isku halaynta natiijooyinka imtixaanka lagu dammaanad qaadi karaa.
Sidee bukaanleyda qaba kansarka caloosha ay u doortaan baaritaanka hidda-socodka?
Shabakada Caalamiga ah ee Oncologist waxay xasuusineysaa bukaanada in baaritaanka hidda-socodka kansarka iyo falanqaynta daaweynta bukaan-socodka ay yihiin mashruuc nidaamsan oo u baahan taageero shaybaar oo xooggan, xakamaynta tayada tijaabada heerka sare ah iyo kooxda falanqaynta xogta heerka sare ah. Falanqaynta wanaagsan ee baaritaanka hidde-sidaha waxay ka fogaan kartaa luminta fursadaha daaweynta waxayna badbaadin kartaa nolosha bukaannada kansarka. Waqtigan xaadirka ah, waxaa jira daraasiin hay'ado baaritaanka hidde-sidaha ah oo suuqa ku jira, bukaannadu waa inay si taxadar leh u doortaan shirkadaha baaritaanka hidda-socodka si loo hubiyo saxnaanta natiijooyinka baaritaanka.
Halkan waxaa ku yaal tiknoolajiyad baaris hidde ah oo ay ansaxisay FDA!
AasaaskaOne®CDx
FoundationOne®CDx waxaa ansixiyay FDA oo ah sheygii ugu horreeyay ee baaritaanka nooca wehel-baarista . As a research tool, it assisted the discovery of countless scientific research results, and accumulated a large amount of data during this period. The current test coverage includes 324 genes and two molecular markers (MSI / TMB) that can predict the efficacy of immune checkpoint inhibitors. It can cover all solid tumors (except sarcoma) and can directly correspond to 17 daaweynta la bartilmaameedsaday oo ay ansaxisay FDA!
Qiimaynta kiliinikada ee hiddo-wadaha kansarka, farsamooyinka sida caadiga ah loo isticmaalo waxaa ka mid ah taxanaha Sanger, genotyping mass spectrometry, fluorescence in situ hybridization (FISH) iyo falanqaynta immunohistochemical (IHC). "Baahinta hal calaamad ee caadiga ah" sida FISH, IHC iyo ogaanshaha hiddo-wadaha badan ee hotspot (gudiga hotspot) ayaa kaliya heli kara hal ama laba nooc oo cilladaha hidde-sidaha muhiimka ah (sida beddelka saldhigga oo keliya). Daraasaduhu waxay muujiyeen in tignoolajiyada isku xigxiga ee jiilka xiga ee ugu dambeeyay ee kansarka dhammaystiran ee baaritaanka hidda-socodka ay ogaan karaan dhammaan afarta nooc ee cilladaha hidde-sideyaasha (beddelka saldhigga, gelinta iyo tirtirka; kala duwanaanshaha lambarka iyo dib u habeynta), waana ka saxsan yahay imtixaannada caadiga ah.
Sidee bukaanjiifka kansarku mari karaa baaritaanka FoundationOne® CDx?
Shiinaha, waa adeeg gorfeyn ah oo ay bixiso Dean Diagnostics. Shabakada Global Oncologist Network waxay ka caawin kartaa bukaanada kansarka inay helaan adeegan, ama baaritaanka hidaha ee shahaado wadaninimo. Shabakadda Global Oncologist Network, oo ah barnaamij caan ah oo loogu talagalay adeegga bukaanka kansarka, waxay ahaan jirtay xarunta Oncology iyo khubaro caan ah oo caan ku ah kansarka si dhow ayey u wada shaqeeyaan si joogto ah u abaabulaan shirar ballaaran oo isweydaarsiga bukaanka iyo casharrada sayniska ee caanka ah si ay uga caawiyaan bukaanada inay helaan heer. iyo qorshaynta ogaanshaha iyo qorshaynta daaweynta iyada oo loo marayo latashiyo khibrad leh gudaha iyo dibedda, iyo in la wanaajiyo heerka daaweynta. Waxaan sidoo kale sameyn doonnaa dadaal joogto ah oo aan si joogto ah ugu soo bandhigeyno macluumaadka ugu horreeya adduunka ee la-dagaallanka kansarka, tikniyoolajiyadda, khubaro, dawooyin, tijaabooyin caafimaad, iwm.
Faa'iidada Kansarka iyada oo ah cilmi-baaris caan ah oo lagu ogaanayo kansarka gudaha iyo la-talinta daaweynta iyo adeegga adeegga, waxaa ka go'an inay bixiso adeegyo heer-ka-hortag ah oo kansar ah oo loogu talagalay bukaannada kansarka ee gudaha, oo ay ku jiraan tiknoolajiyaddii ugu dambeysay ee ka-hortagga kansarka iyo khabiirada ugu sarreeya ee kansarka, oo dejinaya buro la-tashiga iyo xarunta la-talinta ee Hindiya, iyo La Shaqee xarumaha caanka ah ee la-talinta burooyinka iyo khubaro ku sugan Mareykanka, Shiinaha, Israa’iil, iyo Yurub si ay u noqdaan khabiirka la-talinta burooyinka iyo la-talinta daaweynta ee adduunka.
