Scientists at the University of California, San Francisco have discovered a common genetic driver of aggressive meningioma, which can help clinicians detect this dangerous cancer earlier and find new treatments for these difficult-to-treat tumors. A research team led by Dr. David Raleigh found that increased gene activity called FOXM1 seems to be responsible for the aggressive growth, and these tumors frequently relapse.
To investigate the factors that may lead to aggressive meningioma, Raleigh’s team collected 280 human meningioma samples from 1990 to 2015. Using a range of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these burooyinka and patients’ clinical outcomes. Finally, a gene called FOXM1 was found to be the core of the growth of invasive meningioma, and also an indicator of the subsequent adverse clinical outcomes, including death.
Baarayaasha waxa kale oo ay ogaadeen xiriir cusub oo u dhexeeya faafitaanka meningiomas-ka gardarrada ah iyo kicinta dariiqyada tilmaamaha isku-xidhka, ee loo yaqaan Wnt, oo inta badan door ka ciyaara horumarka embriyaha iyo samayska unugyada. Marka la eego in borotiinka ay soo saartay FOXM1 uu gudbin karo calaamadaha wadada Wnt, xogta cusubi waxay muujineysaa in shaqada wadashaqeynta ee FOXM1 iyo Wnt pathway ay horseedi karto faafitaanka xiga ee meningiomas. Hypermethylation-ka ayaa laga yaabaa inuu bilow u noqdo sameynta meningiomas dagaal badan.
Raleigh wuxuu sheegay in shaqada mustaqbalka ay u baahan tahay in la ogaado hiddo sidaha FOXM1 ay u dhaqaajiso si loo wado koritaanka meningioma, loona xannibo bartilmaameedyadan daaweynta daaweynta. Waxaa la rajeynayaa inay jiri doonaan dawooyin lagu joojiyo cudurada maskaxda ee burooyinka maskaxda ee marinkan sida ugu dhaqsaha badan ugana faa'iideystaan inta badan bukaannada kansarka.
