Kansarka sanbabada ayaa ka mid ah sababaha ugu badan ee dadka u dhintaan burooyinka, waxaana heerka cudurkiisa iyo dhimashada uu ka galay kaalinta koowaad ee magaalooyinka. Cilmi-nafsiyeedka inta badan waa kansarka sambabada unugyada aan yarayn (NSCLC), oo qiyaastii ah 85%. Bukaanjiifka badankoodu waxay ku jiraan marxaladaha dhexe iyo kuwa dambe marka la ogaado, iyo 60 ilaa 80% bukaannada kansarka sanbabada ayaa lumiyay fursadda qaliinka markii si dhab ah loo ogaado. Isla mar ahaantaana, sambabku waa xubinta labaad ee ugu fudud ee ugu fudud ee burooyinka adag, oo ay ku xigto beerka beerka. Daaweynta qalliinka waxaa badanaa loo isticmaalaa bukaanada leh tiro xaddidan oo xaddidan oo metastases ah. Qalliinku wuxuu u baahan yahay in laga saaro qayb ka mid ah unugyada sambabada oo leh shaqo caadi ah. Sidaa darteed, hababka cusub ee daaweynta ayaa sidoo kale loo baahan yahay si loo beddelo qalliinka.
In recent years, the minimally invasive radiofrequency ablation (RFA) technology has been used more and more as a minimally invasive treatment method in the treatment of primary / secondary lung tumors, and has made great progress, known as the treatment “Dinghaishen Needle” for kansarka sanbabada.
Waa maxay xad-dhaafka raadiyaha?
Radiofrequency ablation consists of an electrode needle inserted into the buro tissue and an electrode plate attached to the patient’s body to form a current loop. After the RF generator is turned on, high-frequency alternating current at the electrode tip is injected into the target tissue (Figure 2A), causing ions in the tissue to occur Shock, friction and heat generation will follow, causing cell death and coagulation necrosis in the target tissue around the electrode (Figure 2B). At the same time, the vascular tissue around the tumor will coagulate to form a reaction zone, preventing it from continuing to supply blood to the tumor and preventing tumor metastasis. Radio frequency waves can also cause tumor blood vessels to coagulate and reduce blood supply. At the same time, the ablated tumor tissue remains in the body. Due to its composition and structural changes, it can stimulate the body’s immunity and produce anti-tumor cytotoxic antibodies, and induce cytotoxic T cell immunity.
Kansarka sambabada kee ayay RFA khusaysaa?
1. Used for kansarka sanbabada ee aan yareyn that cannot tolerate surgery. Tumor diameter ≤2cm, 78 ~ 96% of patients can achieve complete ablation; tumor diameter ≤3cm, 5-year survival rate exceeds 50%. The treatment effect is better for primary lung cancer with a diameter ≤5cm.
2. For the treatment of lung metastases. Studies have shown that lung metastases with a diameter ≤2-3 cm, patients with lung metastases receiving RFA treatment have a 3-year survival rate of 53.7% and a 4-year survival rate of 44.1%. As shown in Figure 3, a kansarka naasaha patient relapsed with a single left lung metastasis. After RFA treatment, the follow-up and follow-up for nearly 3 years showed a good quality of life and no distant recurrence.
3. Bukaan, dhedig, 48 jir ah, qaba hal sambabada metastasis ka dib qalliinka kansarka naasaha. Daawaynta bukaanada qaba kansarka sanbabada unug yar oo horumaray, oo ay ku jiraan tyrosine kinase inhibitors (TKI), sida Kemena, Iressa ama Trocaine ka dib iska caabbinta daawada maxaliga ah. Tusaale ahaan, daawaynta TKI waxay noqotay ikhtiyaarka daawaynta safka kowaad ee bukaanada leh isbadalada xasaasiga ah ee kor u kaca ee unugyada unugyada unugyada kansarka sanbabada (EGFR). Xarunta Cilmi-baarista Kansarka ee Cisbitaalka Shao Yifu waxay u isticmaashaa tignoolajiyada RFA daaweynta palliative ee kansarka sambabada unugyada aan yareyn iyo mid ka mid ah hababka daaweynta kale ee looga gudbo iska caabbinta TKI.
4: Haweeney 59 jir ah oo qaba kansarka sanbabada unugyada aan yareyn ee unugyada (EGFR mutation) oo leh metastasis gudaha sambabada, 15 bilood ka dib daawaynta afka TKI, burada sambabada midig ee hoose (Jaantus B) way ka caddahay tii hore (Jaantuska A) sida ka muuqata falaarta ayaa kordhay, horumarka cudurka; Daaweynta RFA ee CT-gu hagayo ee burada sambabada midig ee hoose (Jaantus C), oo la raacay bilaha 3 (Jaantus D), 6 bilood (Jaantus E) waxay muujisay xakameyn wanaagsan.
4. Lagu daray kiimoterabiga iyo daaweynta shucaaca. Chemotherapy iyo radiotherapy oo ay weheliso daawaynta soo noqnoqoshada shucaaca ayaa loo isticmaalaa burooyinka beerka ee metastatic iyo sambabada. Codsiga la isku daray ee labada ayaa ka soo kabanaya cilladahooda waxayna kor u qaadi karaan waxtarka. Marka la barbardhigo nooc kasta oo daaweyn ah, waxay dheeraynaysaa wakhtiga badbaadada bukaanka waxayna wanaajisaa tayada nolosha.
The patient, a 58-year-old male, has colon cancer with multiple liver and lung metastases in the distance, making it difficult to operate and treat. Combined with chemotherapy and targeted drug therapy, especially combined with minimally invasive radiofrequency ablation technology, it successfully cured liver and lung metastases.
5. RFA can also be used for palliative treatment to relieve various discomfort symptoms of patients with advanced lung cancer.
6: 88-jir waayeel ah bukaan kansarka sambabada ah ayaa ku soo laba kacleeyay intra-pulmonary and pleural metastasis (oo lagu muujiyey jaantusyada A iyo B). Xanuun daran way adagtahay in la seexdo. Xanuunka bukaanka ayaa si weyn loo nafisiyay ka dib daaweynta RFA ee burooyinka sambabada, tayada hurdada ayaa si weyn loo hagaajiyay. Sannad ka dib dabagal, bukaanku guud ahaan wuxuu ahaa xaalad wanaagsan oo leh burooyinka sambabada oo deggan.
