Bishii Marso 2024, War-saxaafadeed ayaa sheegay in A2B530 (A2 Biotherapeutics), oo ah CAR T-cell therapy, la siiyay Magacaabista Dawooyinka Agoonta si loogu daweeyo kansarka mindhicirka kaas oo muujiya antigen-ka carcinoembryonic (CEA) oo uu lumiyay muujinta HLA-A * 02 ee dadka qaba jeermiska cudurka heterozygous HLA-A*02(+).
Cilmi-baadhayaashu waxay u maleynayaan in daawaynta unug-maskaxeed-maskaxeed ee autologous ay bartilmaameedsan karto unugyada burooyinka iyada oo la ilaalinayo unug caafimaad qaba. Tani waa sababta oo ah waxay leedahay beddelka badbaadada ee ku dhex jira oo ka ilaalin kara unugyada caafimaadka qaba inay dhaawacmaan. Wajiga 1/2 EVEREST-1 (NCT05736731) daraasadda, fikraddan waa la tijaabin doonaa.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T-Cell daaweynta Shiinaha
Go'aanka FDA ee ah in la siiyo Magacaabista Dawooyinka Agoonta waxay xaqiijinaysaa baahida weyn ee aan la daboolin ee daawaynta ka wanaagsan ee dadka qaba kansarka mindhicirka,” William Go, MD, PhD, madaxa caafimaadka ee A2 Bio, ayaa ku sheegay war-saxaafadeed. Magacaabiddani waxay xoojinaysaa ballan-qaadkeenna ah inaan isticmaalno aaladda tignoolajiyada casriga ah si aan u abuurno kansar cusub daawaynta loogu talagalay dadka kansarku ay adag tahay in la daweeyo.
Calaamadda furan, wajiga 1/2 EVEREST-1 daraasadda waxay eegaysaa A2B530 sida daawaynta suurtogalka ah ee burooyinka adag sida kansarka mindhicirka, kansarka ganaca, iyo kansarka sanbabada ee aan yareyn. Waxa kale oo ay eegtaa noocyada kale ee burooyinka adag ee soo saara CEA laakiin aan ahayn HLA-A*02. Dadka hadda ku jira daraasadda EVEREST-1 waxay markii ugu horreysay ku jireen daraasadda BASECAMP-1 (NCT04981119), halkaasoo unugyadooda T la ururiyey, laga baaraandegay, loona habeeyay isticmaalka dambe.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T-Cell therapy for multiple myeloma gudaha Shiinaha
Hadafka ugu weyn ee daraasadda wajiga 1 waa in la helo qiyaasta ugu badbaadsan uguna waxtarka badan. Badbaadada iyo waxtarka waa in la ilaaliyaa sida yoolalka ugu muhiimsan ee daraasadda wejiga 2. Qadarka adag buro Unugyada qiyaasta lagu taliyay ay dili karaan iyagoo weli badbaadinaya unugyada caafimaadka qaba.
Kansarka mindhicirka, kaas oo ah erey labadaba kansarka mindhicirka iyo malawadka, waxay dhacdaa marka burooyinku (kooxaha unugyada isla koraya) ay ku samaysmaan mindhicirka ama malawadka oo isu beddelaan kansar. Da'da weyn, madowga, inuu leeyahay taariikh buro ama kansar oo jidhkaaga ah ama qoyskaaga, cudurada mindhicirka bararka, genetics, sonkorowga, buurnaanta, cuntada caadiga ah ee reer galbeedka, iyo sigaar cabista iyo cabitaanka ayaa ah dhammaan waxyaalaha dadka geliya khatarta.
Qalliin, shucaac, daawaynta la beegsaday, iyo immunotherapy waa hababka ugu badan ee lagu daweeyo kansarka mindhicirka. Si kastaba ha ahaatee, qaar badan oo ka mid ah hababka hadda ee kansarkan iyo kuwa kale ee leh burooyin adag ayaa dili kara bukaanka.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T Qiimaha daawaynta unug ee Shiinaha
Cilmi-baarayaasha ka shaqeeyay daraasadda ayaa u maleynaya in tan CAR T-cell daaweynta wuu ka ammaansan yahay daawaynta kale ee la beegsaday. Tani waa sababta oo ah CAR T-unugyada dila unugyada burooyinka iyaga oo aan dhaawicin unugyada caafimaadka qaba sababtoo ah waxay leeyihiin beddel badbaado leh oo ka ilaalinaya unugyada caafimaadka qaba inay dhaawacmaan.
