Kiisaska NK unugyada difaaca jirka ee kansarka beerka ee horumarsan
92 jir bukaan ah oo qaba cudurka kansarka ayaa leh gabi ahaanba cafis
Toddoba sano ka hor, Ms. M, oo da'deedu ahayd 80-meeyadii, ayaa laga helay kansarka hepatocellular (oo uu sababay kansarku waagii hore ee dhiig ku shubista iyo caabuqa fayraska cagaarshow C). Maadaama ay caafimaad qabtey xilligaas, si guul leh ayaa qaliin looga saaray.
Sannadkii 2016, kansarku wuu soo noqnoqday, laakiin marka la tixgeliyo in Ms. M ay mar hore duqowday xilligan, qalliin mar dambe laguma talin.
Ms. M. was born into a medical family, and her daughter is also a doctor. She consulted on many treatments suitable for mothers other than surgery. Due to the poor location of the buro, radiofrequency and embolization treatments are not feasible. Among the most cutting-edge radiotherapy methods, the first is to exclude heavy ions, which are not applicable at all, and the second is daaweynta proton, iyo hooyada xooggeeda jir ahaaneed waa mid aan loo adkaysan karin. Ugu dambayntii, mindida TOMO oo keliya ayaa si sax ah u ogaan karta cudurka murugsan ee hooyada. Cirridka.
Doctors suggest that Ms. M should be treated conservatively at such an old age. You can try a mild systemic treatment-NK cell reinfusion to improve immunity without using the toxic and side effects of drug treatment. At the same time, combined with Tom knife radiotherapy to kill unugyada kansarka.
Xilliga firfircoonaanta firfircoonida ee unugyada NK dib loogu soo celinayo jirka waa 2-3 maalmood, sidaa darteed Ms. M waxay sameysaa isugeynta NK unug dhamaadka usbuuca dhammaadka ka dib shucaaca maxalliga ah ee mindida TOMO. Unugyada NK waxay la dhaqaajin karaan dhiigga jirka oo dhan si ay u gaaraan deegaanka + iskudhafka daaweynta nidaamsan Saamaynta daaweynta Better ee la-dagaallanka kansarka.
Daaweyn kadib, ultrasound iyo baaritaanka PET-CT waxay muujiyeen in dhaawaca bukaanku kujiro xaalad xagjir ah. Dhaawaca maxalliga ah waa la waayey, welwelka bukaanka ee ku saabsan metastasis ma muuqan, ma jiro cagaarshow iyo ascites, jirkiibana si tartiib tartiib ah ayuu u bogsaday.
NK unugyada daaweynta ka hortagga kansarka
NK (unuga dilaaga dabiiciga ah, NK) waa unugga difaaca ee leh saamaynta ugu xoogan ee kansarka. Waxa ugu xoogga badan waa in aysan u baahnayn habka soo bandhigida antigen-ka oo uma baahna unugyo kale oo difaaca si ay u habeeyaan. Waxay qaadan kartaa hindise, toos ah, oo si degdeg ah uga saari kartaa jidhka shisheeye (Bakteeriyada fayrasku waxay ku dhacdaa unugyada, unugyada kansarka, unugyada dareenka, iwm.) Dib-u-hagaajinta deegaanka.
Inkasta oo ay si dhakhso ah u difaaci karaan oo ay si toos ah u weerari karaan unugyada burooyinka, nasiib daro, unugyada NK waa qayb yar oo ka mid ah habka difaaca jirka, oo xisaabiya kaliya 10% unugyada dhiiga cad. Waxayna daraasaddu sheegtay in da'da 25 sano ka dib, ay hoos u dhacdo difaaca jirka iyo tirada unugyada NK-da. Tirada iyo waxqabadka unugyada NK ee bukaannada burooyinka iyo bukaannada ka dib qalliinka buro ayaa isbeddelay ilaa xad, mana si wax ku ool ah u samayn karaan saamaynta kansarka ka hortagga.
Cilmi-baadhayaashu hadda waxay diiradda saarayaan "korsashada" NK-daawaynta unug-ururinta unugyada NK ee deeq-bixiyeyaasha si dhow ula xiriira oo ay ku duraan bukaannada. Tani waxay caddaysay inay badbaado tahay, oo ka duwan daawaynta unugga T, unugyada NK ma keenaan cudur-tallaalid-ka-hortagga-martigelinta unugyada qaataha.
Si loo hagaajiyo waxqabadka iyo tirada unugyada NK ee jirka ku jira, saynisyahano reer japan ah ayaa ikhtiraacay hab isku dhufasho ah, kaasoo ah in 50ml laga soo saaro dhiiga bini'aadamka, la karantiilo in yar oo unugyada NK ah ka dibna la balaariyo dhaqanka si tirada loogu kordhiyo asal ahaan 1000 jeer, nambarku wuxuu gaaraa 1 bilyan ilaa 5 bilyan, ka dibna jirka ayuu ku noqdaa, tiro aad u tiro badan oo unugyada NK ah ayaa ku wareegi doona 3000 ilaa 4000 jeer dhiigga jirka oo dhan, iyagoo dila unugyada kansarka, unugyada gaboobay, unugyada buka, bakteeriyada iyo fayrasyada jirka Mar labaad, si loo gaaro ujeedka ka hortagga kansarka iyo ka hortagga kansarka, hagaajinta difaaca jirka iyo sii dheereynta jiritaanka.
Waqtigan xaadirka ah, waxaa jira cadeymo badan oo sheegaya in difaaca jirka (unugyada NK) kahor iyo kadib qalliinka ay yareyn karaan halista soo noqoshada iyo metastasis.
Waa maxay sababta bukaanjiifka kansarka beerka ay ugu habboon yihiin daaweynta unugyada NK
Unugyada NK, sida "Molecular Patrol", waxay gaaf wareegayaan socodka dhiigga meel kasta. Mar alla markii ay helaan unugyo shisheeye ama unugyo mutant ah oo lumiyay is-aqoonsi (oo loo yaqaan MHC), soo-dhoweynta unugga NK isla markiiba wuxuu diraa calaamadda oo wuxuu ku degdegaa xuubka unugga bartilmaameedka ah Taasi waa in la yiraahdo, unugyada NK waa inay ku jiraan safka hore ee dagaalka. Waxay ku sii deysaa walxo sun ah, waxay si deg deg ah u milisaa unugyada bartilmaameedka, waxayna keentaa in unugyada kansarku ku dhintaan 5 daqiiqo gudahood.
Waa in la ogaadaa in unugyada NK, oo ah qaybta ugu muhiimsan ee nidaamka difaaca jirka, ay yihiin unugyada difaaca jirka ee ugu qiimaha badan jirka bini'aadamka, laakiin waxay aad ugu yaryihiin dhiiga durugsan ee bini'aadamka, iyaga oo kaliya ka ah 5% -10% ee lymphocytes. Beerka, unugyada NK waxay ku xisaabtamaan 30-50% of lymphocytes.
Marka loo barbardhigo wareegga unugyada NK, unugyada NK ee beerka waxay leeyihiin astaamo u gaar ah astaamo iyo astaamo shaqeynaya, oo muujinaya cytotoxicity ka sarreeya unugyada burooyinka.
During the occurrence of kansarka beerka, the proportion of NK cells and the function of cytokines (interferon-γ) production and cytotoxic activity are reduced.
Sidee unugyada NK u dilaan unugyada kansarka?
Sababta ay unugyada NK u dili karaan unugyada kansarku waa isu dheelitirka calaamadaha aaladaha firfircoon ee firfircoon iyo kuwa wax qabanaya ee dusha sare ee unugyada NK. Molikuyuullada firfircoon ee firfircoon ee firfircoon ayaa lagu muujiyey dusha sare ee unugyada kansarka iyo unugyada cudurka qaba waxaana aqoonsaday unugyada NK. Intaa waxaa dheer, unugyada kansarka iyo unugyada cudurka qaba ayaa inta badan lumiya maaddooyinka MHC I, taasoo ka dhigaysa kuwo u nugul aqoonsiga unugga NK.
Unugyada NK waxay ku jiraan dhiigga dadka waxayna yihiin "jawaabayaasha ugu horreeya." Waxay la mid tahay nin bilays ah oo ku jiray shaqada jidhka. Marka uu dhiiggu wareego, unugyada NK waxay si joogto ah ula xiriiraan unugyada kale inta ay gaaf wareegayaan. Marka cillad aan caadi ahayn laga helo jidhka Unugyada, isla markiiba deggan, sax ah, si naxariis la'aan ah u sugaan wakhti ay wax ka qabtaan. Waxay weeraraan oo ay sii daayaan qaybo cytotoxic ah oo ay ku jiraan perforin iyo granzyme xuubka unugyada bartilmaameedka ka hor inta aan unugyada T la geynin, taasoo kicinaysa is-burburinta unugyada kansarka. Waxay sidoo kale baabi'in karaan unugyada asliga ah ee kansarka ee ku wareegaya jirka waxayna gacan ka geysan karaan ka hortagga metastasis.
Faa'iidooyinka daaweynta unugga NK
1. Daaweynta unugyada difaaca jirka waa habka afaraad ee daawaynta ka dib qalliinka, kiimoterabiga iyo daaweynta shucaaca. Daaweynta unugyada NK oo ay weheliso daaweynta shucaaca iyo kiimoterabiga waxay si wax ku ool ah uga saari kartaa unugyada burooyinka oo aan si buuxda looga saari karin qalliin;
2. Daaweynta unugyada NK ee lagu daro daaweynta shucaaca waxay hagaajin kartaa waxtarka shucaaca waxayna yareyn kartaa dhibaatooyinka soo raaca;
3. Bukaannada kansarka ee horumarsan ee aan ku habboonayn qalliinka ama shucaaca iyo daaweynta kiimikada, daaweynta unugyada NK ayaa ka fiican;
4. Daaweynta joogtada ah ee unugyada NK qalliinka ka dib waxay ka hortagi kartaa soo noqoshada iyo metastasis ee kansarka;
5. Yaraynta xanuunka kansarka, hagaajinta hurdada, hagaajinta tayada nolosha bukaanka, iyo fidinta wareegga nolosha bukaanka;
6. Dadka caafimaadkoodu hooseeyo, isticmaalka daawaynta unugyada NK waxay yarayn kartaa halista kansarka.
Bukaankee ayaa ku habboon daaweynta unugyada NK?
Bukaannada jirkoodu liito qalliinka kahor, soo kabashada qalliinka kadib qunyar, iyo cabsida unugyada kansarka sixirka oo aan gebi ahaanba la baabi'in.
Ka dib shucaaca iyo kemotherabi ka dib, difaacku wuu hooseeyaa, dhibaatooyinka soo raaca waa iska cadahay (sida cunto xumo, lallabbo, timo lumis, maqaarka oo barara, iwm), iyo bukaanada rajaynaya inay kordhiyaan saamaynta kiimiko.
Sababtoo ah cabsida waxyeelada shucaaca iyo daaweynta kiimikada, bukaanada rajeynaya inay isticmaalaan daaweyn kala duwan si ay u gaaraan saameynta daaweynta.
Unugyada kansarka ee burooyinka horumarsan ayaa ku faafay jirka oo dhan, laakiin hababka daaweynta caadiga ah waxay ahaayeen kuwo aan awood lahayn, bukaannada filaya inay sii dheereystaan badbaadada iyo hagaajinta tayada nolosha.
Nidaamka daaweynta daaweynta unugyada NK
1. Dhiig ururinta
Sawir 30-50ml oo dhiig durugsan o
f bukaanada kansarka oo soosaara unugyada mononuclear;
2. Beerista shaybaarka
Shaybaarka, ku samee soo-saarista unugyada NK iyo ballaarinta 5-7 maalmood;
3. Soo noqo
Ka dib marka dhaqanka unugga NK la dhammeeyo, waxaa loogu celiyaa bukaanka kansarka sida faleebo oo kale.
