Maarso 2023: Saynis yahanada soo saaray dawo cusub oo laga yaabo inay wax ku ool u noqoto dhamaan noocyada waaweyn ee kansarka lafaha aasaasiga ah ee carruurta ayaa ku tilmaamay "daah-furka dawooyinka ugu muhiimsan ee duurka ku dhawaad nus qarni."
Tijaabooyin lagu sameeyay jiirarka oo lagu beeray kansarka lafaha bini'aadamka ayaa muujiyay awoodda CADD522 ee lagu joojinayo hidda-wadaha ku xiran awoodda faafinta kansarka.
The findings, which were published in the Journal of Bone Oncology, demonstrated, according to the researchers, that the drug can increase survival rates by 50% without the need for surgery or chemotherapy.
Lead researcher Dr Darrell Green, from the University of East Anglia’s Norwich Medical School, said: “Primary kansarka lafaha is a type of cancer that begins in the bones.
Horumarkan ayaa runtii ah mid muhiim ah sababtoo ah daawaynta kansarka lafaha isma bedelin in ka badan 45 sano.
Dr Darrell Green
"Waa kansarka saddexaad ee ugu caansan carruurnimada adag, ka dib maskaxda iyo kelyaha, oo leh ku dhawaad 52,000 oo xaaladood oo cusub sannad kasta adduunka oo dhan.
"Waxay si degdeg ah ugu fidi kartaa qaybaha kale ee jidhka, tanina waa tan ugu dhibka badan ee nooca kansarka ah.
"Marka uu kansarku faafo, aad bay u adkaanaysaa in lagu daweeyo ujeeddo."
Hadda, kiimoterabiga iyo goynta addimada ayaa ah daawaynta kaliya ee kansarka lafaha, oo leh 42% fursada badbaadada.
Sida laga soo xigtay cilmi-baarayaashu, "daawadooda horumarsan" waxay kordhisaa heerarka badbaadada boqolkiiba 50 waxayna ka maqan tahay dhibaatooyinka adag ee daaweynta kemotherabi, sida timo lumis, daal, iyo jirro.
Cilmi-baadhayaashu waxay falanqeeyeen muunado buro lafo ah oo laga soo qaaday 19 bukaan oo jooga Isbitaalka Royal Orthopedic ee Birmingham ujeedada daraasadda.
Waxay ogaadeen in hidda-wadaha RUNX2 uu ka shaqeeyo kansarka laf-dhabarka oo uu la xiriiro fiditaanka cudurka.
Marka loo eego tijaabooyinka, CADD522 waxay ka hortagtaa borotiinka RUNX2 inuu kor u qaado horumarinta kansarka.
Dr. Green waxa uu yidhi, “Badbaado-la'aanta Metastasis-ka waxa kordhay 50% tijaabooyinkii hore markii dawada cusub ee CADD522 kaligeed la maamulay, iyada oo aan kiimoterabi ama qalliin.
"Waxaan ku rajo weynahay in marka lagu daro daawaynta kale sida qalliinka, tiradan badbaadada la sii kordhin doono.
" Muhiimad ahaan, sababtoo ah hiddo-wadaha RUNX2 inta badan uma baahna unugyada caadiga ah, daawadu ma keento waxyeellooyin sida kiimoterabiga.
Maadaama daawaynta kansarka lafaha aanay waxba iska beddelin in ka badan 45 sano, daahfurkani aad buu muhiim u yahay.
According to the researchers, the drug is currently undergoing toxicology testing, after which the team will seek approval from the MHRA (Medicines and Healthcare products Regulatory Agency) to begin a tijaabada caafimaadka on humans.
Saynisyahano ka socda Jaamacadda Sheffield, Jaamacadda Newcastle, Isbitaalka Royal Orthopedic ee Birmingham, iyo Norfolk iyo Norwich Hospital ayaa sidoo kale ka qeyb qaatay cilmi baarista, oo ay taageereen Sir William Coxen Trust iyo Big C.
Dr. Green waxa uu sheegay in dhimashadii saaxiibkii ugu wacnayd ee kansarka lafaha carruurnimada ay ku dhiirigelisay inuu barto cudurka.
"Waxaan rabay inaan fahmo bayoolajiga hoose ee faafidda kansarka si aan u faragelinno heerka bukaan-socodka oo aan horumarinno daaweyn cusub si bukaan-socodka aysan u marin waxa saaxiibkay Ben sameeyay," ayuu yiri.
