Bishii Diseembar 2007, Marwo 54, oo 2 bilood ka sii darnayd hemoptisia, miisaankeedu wuu yaraaday, rabitaankii cuntada wuu yaraaday, lafo xanuun ayaa ku dhacay. A Baadhitaanka laabta ee CT shaaca ka qaaday a 9 cm x 5.8 cm x 7.2 cm "weyn, lobled, heterogeneously xoojiyay" ee bidixda hoose ee sambabada. Intaas waxaa sii dheer, nabar kale oo yar oo irbad u eg ayaa laga helay lafta bidix ee kore.
Mar dambe, biopsy ayaa la xaqiijiyey inuu yahay mid carqaladeeya, oo dhexdhexaad dhexdhexaad u ah kansarka unugyada sanka ku dhaca. A CT scan waxay muujisay ku lug lahaanshaha muruqyada gidaarka laabta oo ay baratay. Baaritaanka lafteedu wuxuu ahaa mid taban (majiraan wax-soo-saarka). Sidaa darteed, waxaa laga helay T4N1M0-IIIb marxaladda unug aan yareyn kansarka sanbabada.
3 bilood gudahood, Ms. M waxaa lagu daweeyay paclitaxel (260 mg) iyo carboplatin (415 mg) ee wareegyada 3. Tani waxay yaraynaysaa buro ilaa 7cm x 6cm x 5cm. Ka dib, daaweynta kemoradiotherapy ayaa la sameeyay si barbar socota 2 wareegyo oo cisplatin ah (50 mg) iyo 60 Gy ee shucaaca.
Laba bilood ka dib markii la dhammeeyey daawaynta kiimoterabi, Ms. Ms waxay ogaatay inay jirto tijaabo caafimaad oo sambabada ah. tallaalka kansarka waxayna go'aansadeen in ay qaataan tallaalka CIMAvax ka dib markii ay ka fikireen.
80% dadka qaatay daaweynta cyclophosphamide kahor cirbadeynta CIMAvax waxay muujiyeen xoogaa waxqabadyo anti-EGF ah. Tallaalka goobo badan ayaa sii kordhin doona waxtarka.
Baaritaanka CT-ga ee ka horreeya qalliinka ayaa muujiyay nabar 3 cm x 3 cm ah oo ku yaal lafaha hoose (Jaantus 1). Nabarrada calooshiisa sare ee bidix waxay ka yaraayeen 1 cm dhexroorka, iyo dheecaanka xuubka xuubka xuubka ayaa ahaa kan labaad ee daaweynta shucaaca.
Ka dib 3 bilood ee daaweynta tallaalka kansarka sanbabada ee CIMAvax, burooyinku waxay u yaraadeen 2 cm x 2.1 cm
Muddo 6 bilood oo daaweyn ah, burooyinka ayaa ka yaraaday caddadkoodii hore 30% ilaa 1.5 cm x 2.3 cm kahor xasilinta. Waqtigaan, dheecaanka dareemaheeda ayaa sii waday inuu yaraado, iyo qanjidhada maxalliga ah ee maxalliga ahi way yaraadeen.
Intii lagu guda jiray 16-kii tallaal ee ugu horreeyay, Ms. M ma aysan la kulmin wax saameyn ah. Daqiiqado gudahood markii la duray 17aad, xanuunkeeda dhexda ayaa "kordhay" waxaana loo tixgeliyey jawaab celin la xiriirta Fasalka 3. Calaamadaha ayaa yaraaday 10 daqiiqo oo daaweyn ah kadib 10 mg oo ah chlorpheniramine, 200 mg oo hydrocortisone ah iyo 50 mg oo ah tramadol.
Goor dambe, waxay go'aansatay inay joojiso daaweynta tallaalka CIMAvax. Baadhitaanka 'CT scan' ayaa la sameeyay saddex bilood ka dib joojinta daaweynta (18 bilood ka dib markii la bilaabay daaweynta CIMAvax). Lix bilood ayaa ka soo wareegtay baadhitaankeedii ugu dambeeyay, mana jirin wax “isbedel weyn” oo ku yimid cabirka burooyinka (Jaantuska 3), xaaladdeeduna way deggan tahay.
La-socodkii ugu dambeeyay ee-28 bilood kadib joojinta tallaalka-FNM-da dumarka waxay ku jireen xaalad wanaagsan oo caafimaad iyo xasiloon. Xaaladdeeda ECOG waxay ku sii jirtey 0 (ugu fiican). Waqtigaan la joogo, waxay ka badbaaday 48 bilood tan iyo markii cudurka laga helay xaaladdeeduna waa mid deggan.
Marwo Ms tallaalka kansarka sanbabada waxaa loo oggolaaday suuq-geynta Cuba 2008 si loogu dayactiro daawaynta marxaladda IIIB-IV ee kansarka sambabada aan-unug-yarayn ee horumarsan (NSCLC). Tani waa diiwaangelintii ugu horreysay ee tallaalka daaweynta Cuba iyo diiwaangelintii ugu horreysay ee tallaalka kansarka sanbabada ee adduunka.
