FDA waxay siisay dawadii horudhackeeda quzartinib a daaweynta horumarineed. Quizartinib waa FLT3 inhibitor oo baaritaan lagu hayo daawaynta bukaanada qaangaarka ah ee soo noqnoqday / nadiifin FLT3-ITD Myeloid leukemia ba'an AML ). Aqoonsigan ayaa soo dedejin doona horumarka quzartinib waxaana la filayaa inay daawooyin cusub u keento bukaanada sida ugu dhakhsaha badan.
AML waa xumaan blood and bone marrow cancer that causes dysfunctional cancerous leukocytes to proliferate and accumulate uncontrollably, and affects the production of normal blood cells. The United States this year is expected to have more than 19000 Magaca bukaanada cusub ee cudurka laga helay, iyo in ka badan 10000 Ge AML dhimashada. 2005-2011 Natiijooyinka sahanka ayaa muujinaya in 5- heerka badbaadada sanadka ee AML bukaanka waa kaliya 26% , taas oo ah tan ugu hooseysa dhammaan noocyada leukemia. FLT3 isu beddelka hidde-sidaha waa isbeddellada hidde-sidaha ee ugu caansan AML bukaanka, halka FLT3-ITD waa isbedelka ugu badan ee FLT3 hiddo-wadaha, iyo qiyaastii rubuc ka mid ah AML bukaanku sido isbedelkan. Marka loo barbardhigo bukaannada aan qaadin isbeddelkan, bukaannada qaba FLT3-ITD isbeddellada ayaa lahaa saadaal ka sii xun, halis sare oo ah soo noqoshada kansarka, iyo khatarta dhimashada ka dib soo noqoshada. Xitaa haddii bukaannadani helaan xubinta taranka unugyada tarma ee hematopoietic ( HSCT ), fursada kansarka ku soo noqnoqda daaweynta ka dib wali way ka sarreysaa tan bukaanka aan sidin isbedelkan. Xilligan, ma jiro daaweyn la oggol yahay oo cudurkan ah. Sidaa darteed, daaweyntan wax ku oolka ah waxaa laga filayaa inay rajo cusub u keento bukaanka qaba FLT3-ITD .
Marka lagu daro aqoonsiga daaweynta horumarka, quzartinib sidoo kale helay FDA u-qalmitaanka degdegga ah ee soo noqoshada / nadiifin AML therapy , iyo agoonta u-qalmitaanka daroogada AML bixiyay FDA iyo Wakaaladda Daawada Yurub ( EMA ). Quizartinib waa weli ku jira marxaladda cilmi-baarista iyo horumarka oo aan laga oggolaan waddanna. Badbaadada iyo dulqaadka wali lama xaqiijin. Si kastaba ha noqotee, ogolaanshahan ayaa la filayaa inuu soo dedejiyo horumarinta daawada, taas oo runtii war wanaagsan u ah bukaanada.
