George D. Demetri iyo kuwa kale oo ka socda Xarunta Kansarka ee Cisbitaalka Maraykanka ee Dana Fabre / Briegen iyo Haweenka ayaa sheegay in bukaanada qaba liposarcoma, isticmaalka iriprine ee daawaynta dhabarka ay si weyn u wanaajisay faa'iidooyinka badbaadada ee dacarbazine. Bukaanka qaba liposarcoma, waxa ugu muhiimsan waa in la doorto daaweynta iribrin, sababtoo ah nooca pathological ee cudurka ayaa saameyn xaddidan ku leh waxtarka. (J Clin Oncol. Nooca khadka ah Ogosto 30, 2017)
Wajigii hore ee tijaabada kiliinikada III ayaa muujisay in irribrin marka la barbar dhigo dacarbazine ee daaweynta liposarcoma sare ama leiomyosarcoma ay si weyn u wanaajin karto badbaadada guud (OS), iyo dareen-celinta xun ay fududahay in la maareeyo oo la xakameeyo. Hadda cilmi-baarayaashu waxay sameeyeen falanqeyn koox-hoosaad ah oo ku saabsan xaaladda kooxda iribulin iyo kooxda dacarbazine, iyada oo ujeedadu tahay in la caddeeyo qaaska iyo badbaadada unugyada ku habboon.
Xaaladaha diiwaangelinta: da'da bukaanka ≥18 sano; Liposarcoma sare ama sare u kac oo aan lagu daawayn karin qaliin ama shucaac; Dhibcaha heerka waxqabadka ECOG ≤2; Dawooyinkii hore ee kiimoterabiga ≥2, oo ay ku jiraan anthracycline. Bukaan-socodka ayaa si aan kala sooc lahayn loo qaybiyay kooxda erebrin (1.4 mg / m2, d1, 8) ama kooxda dacarbazine (850 mg / m2, 1000 mg / m2, ama 1200 mg / m2, d1) ee 1: 1 ratio. 21 maalmood waa meerto. Dhibcaha waxbarashada waxaa ka mid ah OS, badbaadada aan horumarka lahayn (PFS), iyo badbaadada.
Natiijooyinka waxay muujiyeen in OS ee koox hoosaadka liposarcoma si weyn loo hagaajiyay. Dhexdhexaadinta OS ee kooxaha iribulin iyo dacarbazine waxay ahaayeen 15.6 bilood iyo 8.4 bilood, siday u kala horreeyaan (HR = 0.51, 95% CI 0.35 ~ 0.75; P <001). Kooxda iribulin, bukaanada qaba liposarcoma ee dhammaan noocyada histological subtypes iyo bukaanada gobollada oo dhan waxay ku guuleysteen hagaajinta OS. Dhexdhexaadiyaha PFS ee bukaannada kooxda erebrin waxay ahaayeen 2.9 bilood iyo 1.7 bilood marka loo eego kooxda dacarbazine (HR = 0.52, 95% CI 0.35 ~ 0.78; P = 0.0015). Dhacdooyinka xunxun waxay la mid ahaayeen labada kooxood.
