Cunto “way cuntaa” kansarka mindhicirka
Sanadkii 2014, Mudane Yang oo 65 jir ah iyo xaaskiisa waxay u safreen dibadda. Muddadaas, raaxo-darrada caloosha iyo calaamadaha caloosha ayaa dhacay, laakiin dheg jalaq uma siinin waqtigaas, iyagoo u maleynaya inaysan ku qanacsaneyn ciidda iyo biyaha. Ka dib markii uu ku soo laabtay Shiinaha, astaamaha ayaa si tartiib tartiib ah u fududaaday.
Maalinta Qaranka ee 2014, markii wiilkiisa, gabadha uu soddogga u yahay, iyo wiil uu awoowe u yahay ay aadeen guriga fasaxa, Mr. Yang si lama filaan ah ayuu lallabbo iyo matag u yeeshay markii uu u aaday maqaayadda si uu wax uga cuno. Qof kastaa si degdeg ah ayuu u geeyey cusbitaal weyn oo u dhow si loo baadho. Isla markiiba ka codso cusbitaalka.
However, even greater bad news fell from the sky. Further examination showed that Mr. Yang had not appendicitis but kansarka mindhicirka.
Bishii Nofeembar, Mr. Yang wuxuu maray qalliinka laparoscopic ee semicolon midig. Caadi ahaan, saadaalinta kansarka mindhicirka malawadka ee dhinaca midig ayaa aad uga xun tan dhinaca bidix, laakiin nasiib wanaag, Mr. Yang si dhakhso leh ayuu ku helay qalliinkuna wuxuu ahaa mid aad u deggan. Cudurka jirku wuxuu muujinayaa inuu yahay marxaladda II, oo xilli hore ah.
Qalliinka ka dib, Mr. Yang wuxuu ku soo noqday nolol caadi ah markii uu in muddo ah nasanayay.
Chemotherapy ma aha mid waxtar leh, baaritaanka hidda-socodka waa taban, ma jiraan wax caawimaad ah oo loogu talagalay kansarka mindhicirka sare?
Bishii Maajo 2016, Mr. Yang wuxuu si cad u dareemay inuu mar walba daalan yahay oo uu daalan yahay. Hubaal ku filan, dib u eegista CT waxay muujisay qanjidhada qanjidhada anastomosis ee qaliinkii hore. Baaritaan dheeraad ah ayaa xaqiijiyay soo noqoshada kansarka mindhicirka iyo metastasis ee peritoneum iyo qanjidhada qanjidhada.
He immediately received the FOLFIRI ± cetuximab regimen, but the effect was not satisfactory. Under the advice of the doctor, he conducted a genetic test, and now there are many targeted and immunotherapy daroogada suuqa. Haddii uu jiro isbeddel, waxaa laga yaabaa inay weli jirto Waxaa jira dahaadh lacag ah. Si kastaba ha noqotee, natiijooyinka waxay ahaayeen kuwo niyad jab leh. Tijaabadu ma helin wax isbeddel ah oo macno leh, iyo microsatelite-ka ayaa xasilloon, taas oo macnaheedu yahay in ka-hortaggayaasha kantaroolka kantaroolka difaaca ee loo arko inay yihiin caws-badbaadiyeyaasha bukaannada kansarka aan la isticmaali karin.
Tallaalka unugyada 'Dendritic cell' wuxuu soo saaraa dhammaan dhaawacyada
Isla markii qoyska oo dhami ay quus ka taagnaayeen, saaxiib ka tirsan goobta caafimaadka ayaa kula taliyay Mr. Yang inuu aado Japan si uu isugu dayo daawaynta tallaalka unugyada dendritic.
This is a dendritic cell vaccine that specifically identifies cancer cells in patients by extracting their own tumor cell antigens, because this is an advanced cell immunotherapy, has no side effects, and even cooperates with normal chemotherapy and targeted therapy Can also increase the effect.
I asked the attending doctor in Shiinaha, and it was also recognized. The doctor said that although it is impossible to cure, Japan’s cell immunotherapy is indeed at the global leading level. If the economic conditions allow, you can try to achieve the purpose of prolonging survival and improving the quality of life.
Bishii Ogosto 2016, Mudane Yang iyo xaaskiisa waxay yimaadeen Japan.
Dhakhaatiirta Japan ayaa markii ugu horaysay waxay sameeyeen tijaabo dhamaystiran oo ku saabsan shaqadiisa difaac waxayna ogaadeen in xaddiga unugyada T ee jidhka ku jira ay aad u hooseeyaan, taas oo ah, awooda jidhka ee diida unugyada kansarka kuma filna. Qaddarka tani waxay caawin doontaa daaweynta kiimikada iyo daaweynta tallaalka dambe ee dendritic, iyadoo dhiig laga qaadayo si loo diyaariyo tallaalada unugyada dendritic.
Isla markii uu dhammeeyey dib-u-qaadistiisa ugu horreysay, Mudane Yang dareenkiisa ugu muuqda wuxuu ahaa inuu dareemay tamar buuxda oo jirkiisa ah. Wuxuu dareemi jiray daciifnimo iyo daciifnimo, astaamaha xanuunka ayaa la yareeyay. Cunto xumo awgeed, wuu cuni karaa xoogaa cunto fudud. cuntada.
Bishii Oktoobar 2016, Mr. Yang wuxuu bilaabay inuu ku biiro daaweynta tallaalka unugyada dendritic labadii toddobaadba mar.
Bishii Janaayo 2017, natiijooyinka baaritaanka PET qof walba way ka yaabisay, dhaawacyadii soo noqnoqdayna waa la waayey.
Bishii Janaayo 2018, natiijooyinka dib-u-baarista Mr. Yang waxay mar kale muujiyeen saamaxaad buuxda, iyo dhaawacyada jirka ku jira ayaa gebi ahaanba laga saaray.
Waqtigaan la joogo, qorshaha daaweynta Mr. Yang waxaa loo qaabeeyey inuu soo laabto lixdii biloodba mar si looga hortago soo noqoshada. Illaa iyo hadda, Mr. Yang xaaladdiisu way wanaagsan tahay oo nolol caadi ah ayey ku soo noqotay.
Waa maxay daaweynta tallaalka unugyada dendritic?
Ka dib markaan akhriyay kiiska Mr. Yang, waxaan aaminsanahay in bukaanno badan oo aan waxtar u lahayn daaweynta kemotherabi oo baaritaankooda hidde-sidaha aan lahayn dawooyin bartilmaameed ah ay arkaan rajo.
Dendritic cell vaccine is an ideal therapy. We all know that one of the reasons for the formation of cancer is that cancer cells hide very well. Dendritic cells cannot recognize cancer cells. Imagine that you can put your own cancer cells and dendrites. The cells are fused to form dendritic cells that carry specific antigens on the surface of various cancer cells. These dendritic cells have the ability to recognize buro cells. When we put these cells back into the conductor, he will teach somatic cells to recognize different Cancer antigen cancer cells, one group to find a antigen, one group to find b antigen cancer cells, all of them are eliminated, and at the same time used in combination with the adjuvant therapy of interleukin 12, which enhances T cells in the body, can effectively increase killer T cells The number, so as to achieve the best anti-cancer effect.
Saddex faa iidooyin tallaalka unugyada dendritic
1. Iyadoo lagu saleynayo dib-u-dhiska difaaca jirka ee qaabdhismeedka aadka u gaarka ah, waxaa ka sii bartilmaameed badan, ka saxsan oo wax ku ool ah ka saarista unugyada kansarka.
Dhacdooyinka cudurada faafa ee kaladuwan ee faafa iyo burooyinka jirka waxay si toos ah ulaxiriiraan luminta ama cilladda shaqada DC ee jirka, sidaa darteed soo celinta howlaha gaarka ah ee DC ee jirka waxay fure u tahay daaweynta iyo kahortagga cudurada noocaas ah. Adeegsiga peptides-ka epitope ee aadka u badan, T-DC wuxuu unugyada T ee firfircoon ka dhigayaa kuwo cayiman oo la bartilmaameedsaday, iyo dayactir, dib u soo celin iyo wanaajin kara bukaanka shaqadiisa difaaca jirka, jabinta nidaamka difaaca jirka iyo dulqaadka helitaanka Gobolka, si loo gaaro dib u dhiska jirka oo dhan iyo difaaca jirka ee deegaanka.
2. Sii wad inaad ku bilowdo habka ka saarista non-cytolysis habka ugu muhiimsan ee dilka, oo leh nabadgelyo sare
Daraasaduhu waxay muujiyeen in T-DC ay inta badan isticmaasho abaabulka cytokines kala duwan oo jirka ah sida habka ugu weyn ee lagu nadiifiyo bartilmaameedka, taas oo ka dhigaysa nidaamka difaaca jirka ee dib loo dhisayo inuu si weyn u yareeyo waxyeelada unugyada caadiga ah halka laga saarayo bartilmaameedka.
3. Waxay leedahay saameynta muddada-dheer ee astaamaha tallaalka waxayna ogaataa isku-dhafka dabiiciga ee ka-hortagga iyo daaweynta
DC-ga dib loogu cusbooneysiiyey fitamiin wuu dhaqaajin karaa unugyada T ee nasashada si ay u soo saaraan jawaab celinta bilowga ah ee difaaca markii jirka dib loogu soo celiyo, unugyada T ee firfircoonina waa la weyneyn karaa waana la sii kordhin karaa. Hal dendrite ayaa dhaqaajin kara unugyada 100-3000 T. Inta badan unugyada waxtarka leh ee T waxay door ka ciyaaraan ka saarista fayrasyada, qeybta kalena waxay noolaan doontaa tobanaan sano ilaa tobaneeyo sano si ay u noqdaan unugyada xusuusta T. Marka xigta ee ay u soo gaadhaan dawooyinka antigens-ka ee hooseeya, jawaab celin difaac oo xoog leh ayaa dhici doonta. Sidaa darteed, nidaamka difaaca jirka ee ku saleysan dayactirka iyo dib-u-dhiska T-DC wuu sii shaqeyn karaa tobannaan sano, wuxuuna dib u geli karaa wareegga si uu ugu shaqeeyo xaaladaha ku habboon.
Bukaankee kansarka ah ayaa heli kara daaweynta talaalka unugyada dendritic?
Waa in la ogaadaa in daaweynta talaalka unugyada dendritic aysan wax saameyn ah oo muuqata ku laheyn yareynta burooyinka bukaanada qaba kansarka horumarsan, bukaanada qaba kansarka horumarsan waxay leeyihiin saameynta nolosha sii dheereynta iyagoo ilaalinaya tayada nolosha; iyada oo ah daaweyn loo yaqaan 'adjuvant therapy' qalitaanka ka dib, waxay xakamayn kartaa soo noqoshada oo ay daweyn kartaa Saameynta waa la sii hayn karaa waqti dheer; oo ay weheliso daaweynno kale sida kiimiko ku daweyn, daroogo la bartilmaameedsaday, PD1 inhibitors, saameynta ayaa ka sii fiicnaan doonta. Sidaa darteed, shantan nooc ee bukaanku waa kuwa ugu habboon:
- Bukaannada jirkoodu liito ka hor qalliinka burooyinka, soo kabashada qalliinka ka dib, iyo cabsida unugyada kansarka qarsoon ee aan gebi ahaanba la baabi'in.
- Daawaynta shucaaca iyo kiimoterabiga ka dib, difaacu wuu hooseeyaa, waxyeellooyinkuna waa indho
annaga (sida cunnada oo kaa yaraata, lallabbo, timo lumis, maqaarka oo barara, iwm.), Bukaannada rajeynaya inay kordhiyaan saameynta kiimiko. - Sababtoo ah cabsida waxyeelada shucaaca iyo daaweynta kiimikada, bukaanada rajeynaya inay isticmaalaan daaweyn kala duwan si ay u gaaraan saameynta daaweynta.
- Unugyada kansarka ee burooyinka horumarsan ayaa ku faafay jirka oo dhan, laakiin hababka daaweynta caadiga ah waa kuwo aan awood lahayn, bukaanada rajeynaya inay sii dheereynayaan badbaadada iyo hagaajinta tayada nolosha.
- Bukaanka qaata ka hortagayaasha isbaarada difaaca jirka.
Mainly applicable to solid tumors: head and neck tumors, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, pancreatic cancer, colorectal cancer, ovarian cancer, kansarka ilmo galeenka, renal cancer, prostate cancer, malignant melanoma, sarcoma, partial malignancy Lymphoma.
Sidee bukaanjiifka gudaha u helaan daaweynta tallaalka unugyada dendritic?
Waqtigan xaadirka ah, ma jiraan mashaariic badan oo tijaabo caafimaad ah oo loo oggol yahay daaweynta difaaca jirka ee Shiinaha, iyo qiimaha, amniga iyo suurtagalnimada daaweynta unugyada DC weli lama shaacin. Waxaa la rumeysan yahay in marka siyaasadda guud si buuxda loo bilaabo, ay wadi doonto hirgelinta heerarka hawlgalka daaweynta caafimaad ee khuseeya iyo heerarka Shiinaha waxayna ku dari doontaa fursado cusub oo loogu talagalay daaweynta bukaannada kansarka ee Shiinaha. Mareykanka, Jarmalka, Japan iyo dalal kale oo leh heerar caafimaad oo horumarsan, horumarinta iyo adeegsiga daaweynta unugyada dendritic-ka ayaa safka hore kaga jira adduunka. Tallaalada unugyada 'Dendritic cell' ee Jarmalka iyo Japan ayaa si guul leh loo soo saaray oo loo galay arjiga bukaan socodka. Waad qiimeyn kartaa oo aad ka dalban kartaa Shabakadda Caalamiga ah ee Oncologist (+ 91 96 1588 1588).
Waa in la ogaadaa in saameynta daaweynta jirka ee unugyada ee burooyinka bukaanka qaba kansarka daran aysan muuqan. Bukaannada qaba kansarka horumarsan, waxay u leedahay saameyn ku yeelashada nolosha iyadoo la ilaalinayo tayada nolosha; iyada oo ah daaweyn ku-meel-gaar ah qalliinka ka dib, waxay xakamayn kartaa soo noqoshada iyo saameynta daaweynta Joogtayso waqti dheer; oo ay weheliso kemotherabi, daroogo la bartilmaameedsaday, ka hortagayaasha PD1 iyo daaweyn kale, saamayntu way fiicnaan doontaa.
Cellular immunotherapy is not suitable for all cancer patients. For example, the sarcoma of Wei Zexi is a rare tumor with a high degree of malignancy. There is currently no good treatment in the world. Therefore, cell immunotherapy is naturally not suitable. Therefore, please ensure that you, family members and patients are kept away from false information on the Internet. Before choosing treatment, it must be evaluated by experts in formal and authoritative cancer hospitals. It is very important to choose carefully according to the economic conditions of the family.
