Koox cilmi-baaris ah oo ka socota Xarunta Kansarka ee Abramson (ACC) ee Jaamacadda Pennsylvania School of Medicine ayaa ogaatay in buro ay tahay mid kulul ama qabow ay go'aamiso macluumaadka ku jira unugyada kansarka laftooda. “Hot” tumors are often considered more sensitive to immunotherapy. In a new study published this week in Immunity, the researchers explored the role of “tumor heterogeneity”, namely the ability of tumor cells to move, replicate, metastasize and respond to treatment. These new findings can help oncologists more accurately tailor the unique buro composition of patients.
Ben Stanger, oo ah borofisar ku takhasusay cilladda caloosha iyo unugyada iyo bayoolojiyada koritaanka ee Jaamacadda Pennsylvania Perelman School of Medicine, ayaa sheegay in heerka ay unugyada T u soo jiitaan burooyinka ay nidaaminayaan hiddo-wadayaasha u gaarka ah burooyinka. Si burooyinka ay u koraan, waxay u baahan yihiin inay ka fogaadaan weerarada nidaamka difaaca jirka. Waxaa jira laba dariiqo: in lagu horumariyo burooyin qabow, ama burooyin kulul oo baabiin kara unugyada T, si wax ku ool ah uga ilaaliya unugyada burooyinka waxyeellada nidaamka difaaca bukaanka.
In this study, researchers found that whether a tumor is hot or cold determines whether it will respond to immunotherapy. Cold tumor cells produce a compound called CXCL1, which can instruct bone marrow cells to enter the tumor, keep T cells away from the tumor, and ultimately make the immunotherapy insensitive. In contrast, knocking out CXCL1 in cold tumors promotes T cell infiltration and sensitivity to immunotherapy.
Kooxdu waxay soo saartay khadad taxane ah oo unugyo ah oo shabahaya astaamaha burooyinka ganaca, oo ay ku jiraan noocyada unugyada difaaca jirka ee ay ku jiraan. Mustaqbalka, khadadka unugyada burooyinka waxay gacan ka geysan karaan sii wadista aqoonsiga iyo hagaajinta daaweynta noocyo gaar ah oo bukaanno leh xaalado kaladuwan buro kala duwan.
