Kansarka Appendic waa mid aad dhif u ah, oo ka yar 1% burooyinka caloosha iyo mindhicirka, waxaana jira xog yar oo cilmi ah oo ku saabsan cudurka, taas oo macnaheedu yahay in tilmaamaha hadda jira ee daaweynta kansarka mindhicirka lagu taliyey bukaanka qaba kansarka xuubka. Si loo fahmo sababta qaar ka mid ah bukaanada qaba kansarka sanbabada ay uga jawaabaan daaweynta caadiga ah ee kansarka mindhicirka, halka kuwa kalena aysan samayn, cilmi-baarayaashu waxay sameeyeen falanqayn hidde-side ah oo ah 703 saamiyo kansarka lifaaqa ah. Tani waa daraasadda ugu weyn ee kansarka qabsinka si loo barbardhigo isbeddellada ka jira labada nooc ee kansarka.
Natiijooyinka daraasadda ayaa xaqiijiyay in isbeddellada hidde-sideyaasha ee kansarka lifaaqa ay ka duwan yihiin kuwa kansarka mindhicirka. Isbeddellada TP53 iyo GNAS ayaa ah saadaaliyayaal wanaagsan oo badbaadada bukaannada qaba kansarka lifaaqa. Kansarrada lifaaqa dhifka ah, helitaanka maabyada molecular waxay kaa caawin doontaa go'aaminta fursadaha daawaynta ee suurtogalka ah sababtoo ah ma hayno xogta tijaabada caafimaad si ay u hagto daaweynta caadiga ah sida kansarrada kale. Si la mid ah muhiim, spectrum mutation-ka waxaa loo isticmaali karaa biomarker si loo kala saaro bukaanada khatarta sare leh ee u baahan daaweyn degdeg ah si looga sooco bukaanka khatarta hoose leh.
Daraasad dib-u-eegis ah ayaa lagu ogaaday in kansarka qabsinku uu ka kooban yahay shan nooc oo kala duwan: adenocarcinoma mucinous (46%), adenocarcinoma (30%), kansarka unugyada goblet (12%), peritoneal pseudomyxoma (7.7%), iyo kansarka sanbabada unugyada kansarka (5.2%). Isbeddellada hidde-sideyaasha GNAS ee naadir ku ah kansarka mindhicirka ayaa aad ugu badan kansarka lifaaqa, gaar ahaan adenocarcinoma mucinous (52%) iyo peritoneal pseudomyxoma (72%). Badbaadada dhexdhexaadka ah ee bukaanada qaba burooyinka leh isbeddellada GNAS waxay ku dhow yihiin 10 sano, halka badbaadada dhexdhexaadka ah ee bukaannada qaba burooyinka leh isbeddellada TP53 ay tahay saddex sano oo keliya, iyo badbaadada dhexdhexaadka ah ee bukaannada iyada oo aan lahayn labadan isbeddel hidde-side waa 6 sano.
Daahfurkan la yaabka leh ayaa keenaya su'aasha ah in bukaanada qaba burooyinka GNAS-mutant-ga hore ay u baahan yihiin in lagu daweeyo kiimoterabi sababtoo ah waxaa laga yaabaa in lagu daaweeyo qaliinka oo keliya, sidaas darteed cilmi baaris dheeraad ah ayaa loo baahan yahay si loo caddeeyo.
